Mechanistic insights into the use of rhubarb in diabetic kidney disease treatment using network pharmacology.

In this study, we predicted the core active compounds of rhubarb used in the treatment of diabetic kidney disease (DKD) and the related core gene targets and pathways using network pharmacological approaches.The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to identify active compounds of rhubarb. PharmMapper was used to predict the gene targets of active compounds, which were subsequently provided a standard nomenclature using the UniProt database.

Ebullition Controls on CH Emissions in an Urban, Eutrophic River: A Potential Time-Scale Bias in Determining the Aquatic CH Flux.

Rivers and streams contribute significant quantities of methane (CH) to the atmosphere. However, there is a lack of CH flux and ebullitive (bubble) emission data from urban rivers, which might lead to large underestimations of global aquatic CH emissions. Here, we conducted high-frequency surveys using the boundary layer model (BLM) supplemented with floating chambers (FCs) and bubble traps to investigate the seasonal and diurnal variability in CH emissions in a eutrophic urban river and to evaluate whether the contribution of bubbles is important.