Dual Antiplatelet Treatment up to 72 Hours After Ischemic Stroke Stratified by Risk Profile: A Post Hoc Analysis.

Background: Risk profile of recurrence may influence the effect of antiplatelet therapy. This study aimed to evaluate the efficacy and safety of clopidogrel-aspirin initiated within 72 hours after symptom onset for acute mild stroke or high-risk transient ischemic attack stratified by risk profile.

Methods: This is a secondary post hoc analysis of the INSPIRES (Intensive Statin and Antiplatelet Therapy for Acute High-risk Intracranial or Extracranial Atherosclerosis) randomized clinical trial that enrolled patients 35 to 80 years old with acute mild ischemic stroke or high-risk transient ischemic attack between 2018 and 2022.

EXPRESS: Synergistic Efficacy of Orthokeratology and 0.01% Atropine in Controlling Pediatric Myopia Progression: A Retrospective Analysis.

This study investigates the combined efficacy of orthokeratology lenses and 0.01% atropine in controlling the progression of pediatric myopia. The study, conducted retrospectively on 33 children aged 8-14, measured key parameters, including axial length growth, uncorrected visual acuity (UCVA), intraocular pressure (IOP), tear film breakup time (TBUT), and pupil diameter.

Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects.

Purpose: To evaluate the safety and pharmacokinetics of olaparib tablet test formulation (T) and reference formulation (R) in healthy Chinese male subjects.

Subjects And Methods: This was a single-dose, randomized-sequence, two-way crossover study including three parts: part A: a safety exploration design in lower dose (n = 14, 100 mg), part B: a pivotal comparative pharmacokinetic (PK) trial under fast condition (n = 44, 150 mg) and part C: a pivotal comparative PK trial under food condition (n = 44, 150 mg). Blood samples were collected for 72 hours and the PK parameters of C, AUC and AUC were used to evaluate PK differences.

Glycopeptide microneedles triggering the ECM process to promote fibroblast viability for anti-aging treatments.

Skin anti-aging remains challenging due to the cumulative detrimental effects within the intricate microenvironment. Here, we present glycopeptide hydrogel (γ-PGA/HA) microneedle patches composed of poly (γ-glutamic acid) and hyaluronic acid as a potential solution. These microneedles aim to effectively penetrate the skin barrier while remodeling extracellular matrix to regulate the skin microenvironment.

Rubella antibody levels in the healthy Chinese population: a meta-analysis.

Objectives: To gain a comprehensive understanding of rubella seroprevalence in the healthy population in China and to offer data-driven support for the goal of rubella elimination.

Methods: CNKI, Wanfang database, VIP database, CBM, PubMed, web of Science, and Embase databases were searched to collect studies reporting the positive rate of rubella antibody among the Chinese healthy populations between 2001 and 2022. We conducted a meta-analysis using R language, and data were combined using random effects model.

Single-Cell Analysis Reveals the Cellular and Molecular Changes of Liver Injury and Fibrosis in Mice During the Progression of Infection.

Schistosomiasis is a parasitic disease that poses a serious threat to human health. However, the pathogenic mechanism during the progression of infection remains unclear. In order to elucidate this mechanism, we used single-cell RNA sequencing (scRNA-seq) to investigate the transcriptome characteristics of the cellular (single-cell) landscape in the livers of mice infected with , which were divided into three groups: uninfected mice (0 week (w)), infected mice at 6 w post-infection (the acute phase), and infected mice at 10 w post-infection (the chronic phase).

Laser welding by focusing multi-laser beams.

This paper presents a multi-laser beam focusing on laser welding based on a reflective splitting mirror, aiming to improve the stability of the laser welding process and reduce welding defects. By validating the laser welding process on Q235 mild steel using a newly developed multi-focused laser beam, the results show that by increasing the number of laser focal points, the porosity and spattering are effectively reduced, thus achieving higher process stability. Additionally, the rotation of the laser focal point further reduces the occurrence of welding defects such as porosity and spattering.

Immunological Efficacy and the Impact on Weight of Dolutegravir-Based Regimen in Antiretroviral Therapy (ART)-Naïve Patients with HIV Infection.

Purpose: This study aimed to assess the immunological efficacy and the impact on weight of dolutegravir (DTG)-based antiretroviral therapy (ART) regimen in ART-naive people living with HIV (PLWH).

Methods: A prospective study was conducted on ART-naïve PLWH who treated with DTG-based or efavirenz (EFV)-based regimens in The Second Hospital of Nanjing. Based on previous studies, the sample size was 332 patients calculated by PASS software.

Urban sewage discharge of neonicotinoids and their transformation products threatens aquatic organisms.

Neonicotinoid insecticides (NEOs) are frequently used for urban landscape management and vector control, and undergo various transformation processes when release into urban environments. The discharges of NEOs and their transformation products (TPs) from urban sewer networks may pose serious threats to freshwater ecosystem integrity. However, TPs of NEOs present in municipal wastewater treatment plants (MWWTPs) and their associated risks to aquatic organisms are largely unknown.

Precise photothermal treatment of bacterial infection mediated by charge-switchable nanoplatform with acylsulfonamide betaine surface.

Photothermal therapy (PTT) offers a promising approach for the treatment of drug-resistant bacterial-infected wounds, yet it requires precise targeting of thermal damage to bacteria rather than healthy tissues. Herein, ultrasmall CuS NPs modified with polyzwitterion containing acylsulfonamide betaine (PCBSA@CuS), which provides a sensitive and reversible charge conversion around pH 6.8, are used to enhance the healing of bacteria-infected wounds.

Enhancing the Self-Healing Efficiency of TiAlC MAX Phase via Irradiation.

Self-healing materials are highly desirable in the nuclear industry to ensure nuclear security. Although extensive efforts have been devoted to developing self-healing materials in the past half century, very limited successes have been reported for ceramics or metals. Here, we report an intrinsic self-healing material of TiAlC MAX phase, which exhibits both ceramic and metallic properties, and a strategy for further enhancing the self-healing via irradiation is proposed.

Predicting large-scale spatial ability from small-scale spatial abilities in children: An application of the double-dimension framework.

Wayfinding, a large-scale spatial ability, involves the navigation of one's environment and can be classified into three types of knowledge: route, landmark, and survey. Newcombe and Shipley (2015) proposed a double-dimension spatial framework that classifies spatial abilities into four categories: intrinsic-static, intrinsic-dynamic, extrinsic-static, and extrinsic-dynamic. These abilities are usually assessed in small-scale environments, such as in desktop settings.

Models incorporating physical, laboratory and gut metabolite markers can be used to predict severe hepatic steatosis in MAFLD patients.

Metabolic-associated fatty liver disease (MAFLD) induced-severe hepatic steatosis poses significant health risks. Early prediction of this condition is crucial for prompt intervention. Short-chain fatty acids (SCFAs) and tryptophan are gut metabolites correlated with MAFLD pathogenesis in the gut-liver axis.

Simultaneous Suppression of Multilayer Ion Migration via Molecular Complexation Strategy toward High-Performance Regular Perovskite Solar Cells.

The migration and diffusion of Li, I and Ag impedes the realization of long-term operationally stable perovskite solar cells (PSCs). Herein, we report a multifunctional and universal molecular complexation strategy to simultaneously stabilize hole transport layer (HTL), perovskite layer and Ag electrode by the suppression of Li, I and Ag migration via directly incorporating bis(2,4,6-trichlorophenyl) oxalate (TCPO) into HTL. Meanwhile, TCPO co-doping results in enhanced hole mobility of HTL, advantageous energy band alignment and mitigated interfacial defects, thereby leading to facilitated hole extraction and minimized nonradiative recombination losses.

Associations of sarcopenia, obesity, and metabolic health with the risk of urinary incontinence in U.S. adult women: a population-based cross-sectional study.

Introduction: Urinary incontinence (UI) significantly impairs women's quality of life. Identifying its risk factors is essential for developing effective interventions. Sarcopenia, characterized by the accelerated loss of muscle mass and function, is an emerging concern often linked to obesity and abnormal metabolic status, exacerbating various adverse health outcomes.

A Universal Ternary Solvent System of Surface Passivator Enables Perovskite Solar Cells with Efficiency Exceeding 26.

Surface passivation is a vital approach to improve the photovoltaic performance of perovskite solar cells (PSCs), in which the passivator solvent is an inevitable but easy-ignored factor on passivation effects. Herein, a universal ternary solvent system of surface passivators is proposed through comprehensively considering the solubility and selective perovskite dissolution of the solvent to maximize the passivation effect. Tetrahydrothiophene 1-oxide (THTO) is selected as the passivation promoter by comparing the binding energy with perovskite and the ability to distort the perovskite lattice among various aprotic polar solvent molecules, which can facilitate the passivator's reaction with perovskite and achieve sufficient passivation on perovskite surface.

Cerebral small vessel disease was associated with the prognosis in ischemic stroke with atrial fibrillation.

Background: The purpose of this study was to explore the relationship between atrial fibrillation (AF), cerebral small vessel disease (CSVD), and ischemic stroke.

Methods: Data were extracted from China's Third National Stroke Registry (CNSR-III), which registered 15,166 patients in China. A total of 12,180 ischemic stroke patients were included excluding those diagnosed with TIA or without MRI.

Water-soluble polysaccharides extracted from Enteromorpha prolifera/PVA composite film functionalized as ε-polylysine with improved mechanical and antibacterial properties.

The issue of environmental protection has received sustained and widespread attention. In order to reduce environmental pollution related to traditional plastics, it is an incessant demand to design novel environment-friendly food packaging materials with excellent performance. Sulfated polysaccharide extracted from the "green tide" marine pollution Enteromorpha prolifera (SPE) has been innovatively transformed into a film-forming material for better utilization.

Artificial intelligence-assisted oculo-gait measurements for cognitive impairment in cerebral small vessel disease.

Introduction: Oculomotor and gait dysfunctions are closely associated with cognition. However, oculo-gait patterns and their correlation with cognition in cerebral small vessel disease (CSVD) remain unclear.

Methods: Patients with CSVD from a hospital-based cohort (n = 194) and individuals with presumed early CSVD from a community-based cohort (n = 319) were included.