Aim: Atopic dermatitis (AD) often accompanies skin infections, and bacterial skin infections often cause persistent and worsening symptoms. In this study, we explored the key changes in the microbiota of AD patients, as well as the effects of different ages and the severity of rash on changes in the microbiota.
Patients And Methods: A total of 95 AD patients and 77 healthy volunteers were recruited.
Background: The association between hypothyroidism and Parkinson's disease (PD) has sparked intense debate in the medical community due to conflicting study results. A better understanding of this association is crucial because of its potential implications for both pathogenesis and treatment strategies.
Methods: To elucidate this complex relationship, we used Bayesian co-localisation (COLOC) and bidirectional Mendelian randomization (MR) analysis.
Introduction: Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. Skin microecological imbalance is an important factor in the pathogenesis of AD, but the underlying mechanism of its interaction with humans remains unclear.
Methods: 16S rRNA gene sequencing was conducted to reveal the skin microbiota dynamics.
Background: The aim of this study is to investigate the prevalence of myopia and high myopia and the associated risk factors in key schools in Xi'an, China.
Methods: This cross-sectional study started in September 2021 and was conducted for one month. A total of 11,011 students from 10 key primary schools, five key junior high schools and five key high schools in Xi'an were randomly selected to undergo visual acuity measurement and non-cycloplegic autorefraction.
We revealed abiotic components (extracellular polymeric substances, EPSs) in the periphytic biofilms. Further, the effect of the microbial community on the EPS, and the geodistribution patterns and ecological functions of the EPS were studied.
View Article and Find Full Text PDFA key question that has remained unanswered is how pathogenic fungi switch from vegetative growth to infection-related morphogenesis during a disease cycle. Here, we identify a fungal oxylipin analogous to the phytohormone jasmonic acid (JA), as the principal regulator of such a developmental switch to isotropic growth and pathogenicity in the rice-blast fungus . Using specific inhibitors and mutant analyses, we determined the molecular function of intrinsic jasmonates during pathogenesis.
View Article and Find Full Text PDFMethods Mol Biol
December 2020
Liquid chromatography-mass spectrometry (LC-MS) is one of the most important analytical chemistry techniques for the detection and characterization of biologically active compounds of low abundance-for example, hormones. Gas chromatography (GC) coupled with mass spectrometry has been a method of choice to detect jasmonic acid, the well-known defense hormone in plants. Recently, we identified structural and functional analogs of phytohormone jasmonic acid (JA) and its derivatives, in the rice-blast fungus Magnaporthe oryzae.
View Article and Find Full Text PDFNatural cellulose-based materials (CBMs) have considerable potential as strong and lightweight materials for advanced structural applications. Herein, we demonstrate a mechanically strong yet lightweight CBM with highly aligned wood fibers by the coupling pulping of wood blocks with mechanical pressing, which exhibits a tensile strength of 719.0 ± 30.
View Article and Find Full Text PDFThree-dimensional (3D) porous scaffolds made of biopolymers have attracted significant attention in tissue engineering applications. In this study, cellulose-nanofibers/polyethylene glycol diacrylate (CNFs/PEGDA) mixture, a novelty 3D material, was prepared by physical mixing the CNFs with a waterborne photopolymerizable acrylic resin (PEGDA). Then the CNFs/PEGDA mixture was used to fabricate 3D cytocompatibility CNFs/PEGDA hydrogel scaffold by stereolithograph(SLA)process.
View Article and Find Full Text PDFPhytohormone networks are crucial for maintaining the delicate balance between growth and biotic stress responses in plants. Jasmonic acid, salicylic acid, ethylene, and the associated signaling crosstalk are important for pathogen defense; whereas gibberellin and cytokinin function in growth and development in plants. Plant pathogenic fungi have evolved remarkable strategies to manipulate and/or hijack such phytohormone signaling cascades for their own benefit, thus leading to susceptibility and disease in host plants.
View Article and Find Full Text PDFA viable solution toward "green" optoelectronics is rooted in our ability to fabricate optoelectronics on transparent nanofibrillated cellulose (NFC) film substrates. However, the flammability of transparent NFC film poses a severe fire hazard in optoelectronic devices. Despite many efforts toward enhancing the fire-retardant features of transparent NFC film, making NFC film fire-retardant while maintaining its high transparency (≥90%) remains an ambitious objective.
View Article and Find Full Text PDFPhosphorus (P), an essential macronutrient for all living cells, is indispensable for agricultural production. Although Arabidopsis (Arabidopsis thaliana) PHOSPHATE RESPONSE1 (PHR1) and its orthologs in other species have been shown to function in transcriptional regulation of phosphate (Pi) signaling and Pi homeostasis, an integrative comparison of PHR1-related proteins in rice (Oryza sativa) has not previously been reported. Here, we identified functional redundancy among three PHR1 orthologs in rice (OsPHR1, OsPHR2, and OsPHR3) using phylogenetic and mutation analysis.
View Article and Find Full Text PDFPhosphate transporters (PTs) mediate phosphorus uptake and are regulated at the transcriptional and posttranslational levels. In one key mechanism of posttranslational regulation, phosphorylation of PTs affects their trafficking from the endoplasmic reticulum (ER) to the plasma membrane. However, the kinase(s) mediating PT phosphorylation and the mechanism leading to ER retention of phosphorylated PTs remain unclear.
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