Publications by authors named "Yingxi Wu"

Neuroendocrine tumor (NET) is a deadly malignancy disease that can be found anywhere in the body. The lack of tumor-specific treatment led to the worse prognosis of NET. Anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs), such as alectinib and crizotinib, have been used in the treatment of NET patients with ALK rearrangement.

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Malignant mesothelioma is a rare highly invasive tumour originating from the mesothelial cells of the pleura, peritoneum and pericardium. Malignant pleural mesothelioma (MPM) is the most common type in all malignant mesothelioma. The onset of MPM is associated with exposure to asbestos and it can have an incubation period of up to 40 years.

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  • The study focuses on cranial regeneration in young patients with cranial defects, exploring influences on the regeneration process.
  • Two groups were analyzed: one with successful cranial regeneration (>4 cm²) and a control group with minimal or no regeneration (<4 cm²) after a more extended period.
  • Results showed that complications following surgery significantly hindered cranial regeneration, indicating that managing these complications can lead to better outcomes.
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  • The study investigates surgical techniques and clinical characteristics related to calvarial metastases, aiming to provide an in-depth review of treatment methods for these tumors.
  • It analyzed data from 12 patients who had surgical interventions for calvarial metastatic tumors, including resection and titanium mesh repair, with all patients receiving follow-up treatments like radiotherapy and chemotherapy.
  • Results indicated varied outcomes, including cases of multiple tumors requiring different treatment approaches, instances of dura mater and brain tissue invasion, and a follow-up period where some patients experienced recurrences.
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  • The study aimed to evaluate outcomes and cancer progression in 48 patients who had reoperations for recurrent solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) at Tangdu Hospital between 2010 and 2021.
  • Of these patients, the median time to recurrence after surgery was about 40 months, with 3-, 5-, and 10-year progression-free survival rates at approximately 54.6%, 29.5%, and 14.8%, and median overall survival of 70 months.
  • The results showed that 56.3% of patients achieved gross total resection (GTR), but 9 tumors exhibited malignant progression, with some lower-grade tumors advancing to
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  • Leptomeningeal metastasis (LM) is a serious complication of non-small cell lung cancer (NSCLC), and this study investigates the effectiveness and safety of high-dose furmonertinib, a pan-EGFR tyrosine kinase inhibitor, for patients with this condition.
  • The study included 48 patients with EGFR-mutated NSCLC and LM, focusing on overall survival and clinical response rates, with participants receiving furmonertinib either alone or with other treatments.
  • Results showed a median overall survival of 8.43 months and a clinical response rate of 75%, while adverse events were consistent with previous findings, with some patients needing dosage adjustments due to side effects.
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Objective: The primary objective of this study was to explore the clinical characteristics of apoplectic intratumoral hemorrhage in gliomas and offer insights for improving the diagnosis and treatment of this disease.

Methods: We analyzed the clinical data of 35 patients with glioma and hemorrhage. There were eight cases of multiple cerebral lobe involvement, and 22 cases involved a single lobe.

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Objective: The objective of this study was to evaluate the clinical effect and safety of the postauricular infratemporal fossa approach (ITFA) in resecting jugular foramen lesions.

Methods: All 25 patients undergoing microsurgery via postauricular ITFA from March 2015 to May 2023 in the Department of Neurosurgery, Tangdu Hospital, Air Force Military Medical University were included. The clinical and radiological data were retrospectively analyzed.

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The incidence of lung cancer brain metastasis combined with hemorrhagic cerebral venous sinus thrombosis (CVST) is very rare, and the understanding and treatment experience of this case is insufficient. We reported a case of lung cancer brain metastasis accompanied by venous sinus thrombosis, and describe the diagnosis and treatment plan for colleagues to learn from experience and lessons.

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Objective: Cerebral venous infarction (CVI) after vein injury during intraoperative lesion resection is associated with intracranial hemorrhage. We conducted this study to identify the incidence, clinical and imaging features, and prognosis of hemorrhage CVI.

Methods: We performed a retrospective analysis of patients with confirmed CVI after vein injury who underwent craniotomy in our hospital.

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The incidence of cerebral herniation caused by intratumoral hemorrhage (ITH) in cystic oligodendroglioma (COD) is exceedingly rare. This study presents a case of cerebral herniation subsequent to cystic oligodendroglioma (COD) and sudden intratumoral hemorrhage. Following initial emergency treatment and evaluation, we successfully circumvented the solid component of the tumor and proceeded with cystic puncture and external drainage to prevent the incidence of brain herniation and mitigate the severity of associated symptoms.

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Background: Treatment options remain rather limited for extensive disease small cell lung cancer (ED-SCLC) patients in second or further-line setting.

Methods: The phase 2 investigator-initiated non-randomized study enrolled patients who had disease progression on at least one line of platinum-based chemotherapy. Participants received intravenous sintilimab 200 mg on day one and oral daily anlotinib 12 mg on days 1-14 once every three weeks per cycle.

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Objective: To analyze the factors associated with EGFR-mutated lung cancer with leptomeningeal metastasis (LM) in the real world that affects the prognosis of patients.

Materials And Methods: The clinical data of 123 patients with advanced EGFR mutated lung cancer combined with LM treated at Henan Cancer Hospital and confirmed by histology between January 2016 and December 2020 were retrospectively collected, and all patients were followed up until September 2021. Analyze the median overall survival (mOS) time of patients with clinical characteristics and treatment factors to explore the factors influencing the prognosis of lung cancer patients with LM.

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  • The study explored how G1, a GPER1 agonist, affects neurological issues and inflammation in mice with traumatic brain injury (TBI).
  • G1 treatment led to reduced brain swelling and blood-brain barrier damage, while also improving anxiety and cognitive function in TBI mice.
  • Findings revealed that G1 administration decreased harmful inflammation markers and promoted beneficial microglial activation, suggesting a role in mitigating cognitive deficits post-TBI.
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Background: Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC), with poor treatment outcomes worldwide. Dynamin-related protein 1 (DRP1), which is encoded by the dynamin 1-like () gene, acts as a regulator of mitochondrial fission and plays crucial roles in tumor initiation and progression. However, the clinical value and immune regulation of in LUAD have not been explored.

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Leptomeningeal metastasis (LM) is a serious complication of advanced non-small cell lung cancer (NSCLC), and the incidence of LM has been increasing yearly in recent times. There is no consensus on the best treatment modality for LM, which underscores a difficult problem in the management of advanced NSCLC patients. The existing treatments include molecular targeted therapy, systemic chemotherapy, local radiotherapy, antivascular tumor therapy, intrathecal chemotherapy, and immunotherapy, but their efficacy is not satisfactory.

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  • Glioma is the most common type of primary brain tumor, and while traditional treatments like surgery and chemotherapy exist, their effectiveness is limited, prompting interest in immunotherapy as a new treatment avenue.
  • This study conducted a bibliometric analysis of glioma immunotherapy research published from 1990 to 2023, examining publication trends, authors, and key research milestones using various analysis tools.
  • The analysis revealed a total of 1,929 publications, with the U.S. leading in contributions and immune-checkpoint inhibitors emerging as a key research focus, guiding future directions in glioma immunotherapy.
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Intracranial chondrosarcoma is a rare tumor with limited reports. We reviewed the clinical outcomes, imaging findings, and pathological characteristics at three centers to improve the diagnosis and treatment of intracranial chondrosarcoma. We retrospectively analyzed 26 patients with intracranial chondrosarcoma who had undergone surgical treatment at Tangdu Hospital of Air Force Military Medical University, Mianyang Central Hospital, and Nanchong Central Hospital from January 2010 to July 2022.

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The incidence of unplanned reoperation after surgery during the same hospitalization is considered one of most important evaluation indicators for health care quality. The purpose of this study was to determine the incidence and risk factors related to unplanned reoperation after an endoscopic endonasal approach (EEA). All patients who underwent elective endoscopic endonasal surgery from January 2016 to December 2021 in the Department of Neurosurgery, Tangdu Hospital, Air Force Military Medical University, were included.

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Objective: The anterior clinoid process (ACP) is surrounded by nerves and vessels that, together, constitute an intricate anatomical structure with variations that challenges the performance of individualized anterior clinoidectomy in treating lesions with different extents of invasion. In the present study, we established a 6-surface system for the ACP based on anatomical landmarks and analyzed its value in guiding ACP drilling and resection of paraclinoid meningiomas.

Methods: Using the anatomical characteristics of 10 dry skull specimens, we set 9 anatomical landmarks to delineate the ACP into 6 surfaces.

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Intracranial hemangiopericytoma is a rare invasive tumor originating from mesenchymal fibroblasts and is prone to local recurrence and distant metastasis. This study reports a case of a 27-year-old woman who presented with severe headache, nausea and vomiting for two weeks at thirty-three weeks of gestation. Cranial magnetic resonance imaging (MRI) demonstrated a giant lesion in the bilateral parietal lobe with a size of 5.

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