The correlation between HOMA-IR and cardiometabolic risk index among different metabolic adults: a cross-sectional study.

Aims: This study aimed to explore the correlation between homeostasis model assessment of insulin resistance(HOMA-IR)and cardiometabolic risk index(CMRI) among different metabolic adults to evaluate the value of HOMA-IR in predicting cardiometabolic risk.

Methods: This cross-sectional study was conducted over 18 months (from August 1, 2020 to February 18, 2022) and included 1550 participants divided into non-metabolic syndrome (non-MetS) group (n = 628) and metabolic syndrome (MetS) group (n = 922) in three centers of China. Logistic regression analysis was employed to investigate the correlation between HOMA-IR, body fat percentage, BMI (body mass index), visceral fat index, waist-to-hip ratio, vitamin D, and CMRI.

Construction of core-shell magnetic metal-organic framework composites FeO@MIL-101(Fe, Co) for degradation of RhB by efficiently activating PMS.

Low catalytic efficiency and catalyst recovery are the key factors limiting the practical application of advanced oxidation processes. In this work, a core-shell magnetic nanostructure FeO@MIL-101(Fe, Co) was prepared a simple solvothermal method. The core-shell structure and magnetic recovery performance were characterized by various technologies.

Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway.

Background: Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway remodeling is the main pathology of chronic obstructive pulmonary disease (COPD) and is caused by epithelial-to-mesenchymal transition (EMT) and fibroblast differentiation and proliferation. Effective therapies are still lacking.

Impact of cervical intraepithelial neoplasia and treatment on IVF/ICSI outcomes.

Study Question: Does treatment selection for cervical lesions affect the outcome of IVF/ICSI?

Summary Answer: There was no difference in pregnancy outcome between treated and untreated groups, or between different types of IVF/ICSI treatment.

What Is Known Already: Human papillomavirus (HPV) infection and HPV-induced cervical lesions are associated with decreased fertility, and cervical intraepithelial neoplasia (CIN) treatment may increase the risk of adverse pregnancy outcomes.

Study Design, Size, Duration: Between 2018 and 2020, 190 women with infertility who had abnormal HPV screening or cytology results prior to IVF/ICSI, and were diagnosed with CIN2/CIN3 by colposcopy biopsy at a tertiary hospital, were enrolled in a retrospective cohort study with follow-up until 31 December 2021.

Functionalized nanozyme with drug loading for enhanced tumour combination treatment of catalytic therapy and chemotherapy.

Nanozyme-based tumour catalytic therapy has attracted widespread attention in recent years, but the therapeutic efficacy is limited due to the trapping of hydroxyl radicals (˙OH) by endogenous glutathione (GSH) in the tumour microenvironment (TME). Zr/Ce-MOFs/DOX/MnO is constructed in this work to serve as a new kind of nanozyme for combination chemotherapy and catalytic treatment. Zr/Ce-MOFs can produce ˙OH in a mimic TME, and the MnO on the surface could deplete the GSH, further promoting the ˙OH generation.

Identification and Analysis of Necroptosis-Related Genes in COPD by Bioinformatics and Experimental Verification.

Chronic obstructive pulmonary disease (COPD) is a heterogeneous and complex progressive inflammatory disease. Necroptosis is a newly identified type of programmed cell death. However, the role of necroptosis in COPD is unclear.

Glycyl-l-histidyl-l-lysine-Cu rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.

Background: Skeletal muscle dysfunction is an important co-morbidity in patients with chronic obstructive pulmonary disease (COPD) and is significantly associated with increased mortality. Oxidative stress has been demonstrated an important trigger for COPD-related skeletal muscle dysfunction. Glycine-histidine-lysine (GHK) is an active tripeptide, which is a normal component of human plasma, saliva, and urine; promotes tissue regeneration; and acts as an anti-inflammatory and antioxidant properties.

Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease.

Purpose: Although cigarette smoke exposure is the major risk factor for chronic obstructive pulmonary disease (COPD), the mechanism is not completely understood. The aim of the present study was to investigate whether ACSL4-mediated ferroptosis in lung epithelial cells plays a part in the COPD development process and its association.

Patients And Methods: In this study, animal and cell models of COPD were modelled using cigarette smoke extracts (CSEs), and cell viability, lipid ROS, iron ion deposition, and ferroptosis-related markers were measured in lung tissue and lung epithelial cells following CSE exposure.

Synthesis of bimetal MOFs for rapid removal of doxorubicin in water by advanced oxidation method.

Doxorubicin (DOX) has been an emerging environmental pollutant due to its significant genotoxicity to mankind. Advanced oxidation processes are a potential strategy to remove DOX in water solution. To develop a highly efficient catalytic agent to remove DOX, bimetal MOFs were synthesized, with Cu and Co as the central ions and adenine as the organic ligand.

Construction nanoenzymes with elaborately regulated multi-enzymatic activities for photothermal-enhanced catalytic therapy of tumor.

In order to solve the limitation of tumor microenvironment on the anticancer effect of nanozymes, a multifunctional nanoenzyme Co/La-PB@MOF-199/GOx was designed in this work. By doping Co and La in different proportions, Co/La-PB with the optimal photothermal-enhanced catalytic performance was screened, which can catalyze HO to generate more hydroxyl radicals (•OH) and oxygen, showing peroxidase (POD)-like and catalase(CAT)-like property. Through MOF-199 coating and loading glucose oxidase (GOx), a multifunctional nanoenzyme Co/La-PB@MOF-199/GOx was achieved.

Achieving a "all in one" Fe/Tm-MOFs with controllable photothermal and catalytic performance for imaging-guided multi-modal synergetic therapy.

Targeting excess HO in the tumor microenvironment, nanotheranostic agents for catalytic therapy are designed based on Fenton reaction, catalyzing HO into oxygen and hydroxyl radical (OH). But the catalytic efficiency in tumor microenvironment is not satisfactory. In order to solve the problem, a series of bimetallic-dual ligands metal-organic frameworks Fe/Tm-MOFs were designed, that Fe and Tm as metalions, 2-methylimidazole and trimesic acid as ligands.

Characterization of precipitation from citrus vinegar during ageing: chemical constituents, formation mechanism and anti-proliferative effect.

Precipitation formation commonly occurs in the ageing step of fermented citrus vinegar. Hitherto, the chemical characteristics and biological properties of precipitates remain unveiled. This study focused on investigating the chemical profile, formation mechanism and biological repurposing of precipitates.

Effectiveness of Telemonitoring for Reducing Exacerbation Occurrence in COPD Patients With Past Exacerbation History: A Systematic Review and Meta-Analysis.

Although an increasing number of studies have reported that telemonitoring (TM) in patients with chronic obstructive pulmonary disease (COPD) can be useful and efficacious for hospitalizations and quality of life, its actual utility in detecting and managing acute exacerbation of COPD (AECOPD) is less established. This meta-analysis aimed to identify the best available evidence on the effectiveness of TM targeting the early and optimized management of AECOPD in patients with a history of past AECOPD compared with a control group without TM intervention. We systematically searched PubMed, Embase, and the Cochrane Library for randomized controlled trials published from 1990 to May 2020.

Degradation of organic dyes by peroxymonosulfate activated with water-stable iron-based metal organic frameworks.

In this study, MIL-101(Fe) is prepared via a facile solvent-thermal method, and then applied as catalyst for activating PMS, thus generating reactive radicals for organic dyes removal in aqueous solution. Rhodamine B (RhB), Malachite Green (MG) and Methylene Blue (MB) were selected as model pollutants. The experiments showed that MIL-101(Fe)/PMS had higher removal efficiency for dyes than MIL-101(Fe), indicating that MIL-101(Fe) can be simultaneously used as adsorbent and PMS-activating catalyst for dyes removal.

Facile Strategy to Generate Charged Droplets with Desired Polarities.

Water droplets are usually charged positively via either electrospray or contact electrification at the solid/liquid interface. Herein, we describe a facile two-step strategy to generate charged droplets with desired polarities. In particular, negatively charged droplets can be generated via electrostatic induction using a precharged superamphiphobic substrate as an electret.

DOX sensitized upconversion metal-organic frameworks for the pH responsive release and real-time detection of doxorubicin hydrochloride.

Drug resistance is a major obstacle in cancer treatment, and designing a material that monitors real-time drug release remains a top priority. In this study, metal-organic frameworks doped with lanthanum and thulium were synthesized and then coated with aminated silica to form La/Tm-MOF@d-SiO as a drug carrier. Doxorubicin hydrochloride (DOX) was selected as a drug model, and the drug loading and release were investigated.

Synthesis of 'dual-key-and-lock' drug carriers for imaging and improved drug release.

In this work, a 'dual-key-and-lock' drug carrier was designed to respond to the tumor microenvironment (TME). A core-shell Fe-MOF@ZIF-8 was synthesized, with ZIF-8 as the shell (the first lock) to encapsulate catalase (CAT), and the Fe metal-organic framework (MOF) as the core (the second lock) to encapsulate the anticancer drug doxorubicin (DOX). Fe-MOF@ZIF-8 takes advantage of the TME-which includes a high concentration of HO, a weakly acidic environment and hypoxia-to achieve efficient cancer therapy.

Acetaldehyde-modified-cystine functionalized Zr-MOFs for pH/GSH dual-responsive drug delivery and selective visualization of GSH in living cells.

In recent years, the construction of drug carriers that integrate diagnosis and treatment has become a new trend. In this article, a metal-organic framework (Zr-MOF) was synthesized and functionalized using acetaldehyde-modified-cystine (AMC) to form the functional drug carrier Zr-MOF/AMC which could be used to determine the concentration of glutathione (GSH) for cancer diagnosis, and to achieve pH/GSH dual-responsive release of methotrexate (MTX) for cancer therapy. The cleavage of the AMC disulfide bond by GSH generates two fluorescent molecules that produce strongly enhanced fluorescence, and the intensity is proportional to the GSH concentration.

A multifunctional composite FeO/MOF/l-cysteine for removal, magnetic solid phase extraction and fluorescence sensing of Cd(ii).

FeO/MOF (metal organic framework)/l-cysteine was synthesized and applied for the removal of Cd(ii) from wastewater. The adsorption kinetics and isotherms were investigated, and the results indicated that the adsorption obeyed the pseudo-second-order kinetic model and Langmuir isotherm. The maximum adsorption capacity was calculated to be 248.

Controllable synthesis of a novel magnetic core-shell nanoparticle for dual-modal imaging and pH-responsive drug delivery.

In this study, novel magnetic core-shell nanoparticles FeO@La-BTC/GO have been synthesized by the layer-by-layer self-assembly (LBL) method and further modified by attachment of amino-modified PEG chains. The nanoparticles were thoroughly characterized by x-ray diffraction, FTIR, scanning electron microscopy and transmission electron microscopy. The core-shell structure was shown to be controlled by the LBL method.

Purple foliage coloration in tea (Camellia sinensis L.) arises from activation of the R2R3-MYB transcription factor CsAN1.

Purple foliage always appears in Camellia sinensis families; however, the transcriptional regulation of anthocyanin biosynthesis is unknown. The tea bud sport cultivar 'Zijuan' confers an abnormal pattern of anthocyanin accumulation, resulting in a mutant phenotype that has a striking purple color in young foliage and in the stem. In this study, we aimed to unravel the underlying molecular mechanism of anthocyanin biosynthetic regulation in C.

[Modified TRIzol method for RNA and DNA co-extraction from blood].

Objective: To establish a new method for RNA and DNA co-extraction from the same sample by TRIzol reagent.

Methods: After the aqueous phase which contained total RNA was removed by traditional TRIzol method, the values of pH of the interphase phase and organic phase were adjusted. The DNA was precipitated with ethanol and purified with DNA IQ system.

[A new method of identifying the peripheral blood and the menstrual blood].

Objective: To explore the tissue-specific gene expressions of the peripheral blood and the menstrual blood, and to search some specific factors to establish an effective method for identifying the peripheral blood and the menstrual blood.

Methods: The specific products of the peripheral blood and the menstrual blood were detected by RT-PCR and separated by electrophoretic technology.

Results: Beta-spectrin (SPTB) as one specific marker of peripheral blood and 18S rRNA as a kind of the housekeeping gene were expressed in both the peripheral blood and the menstrual blood.

Langevin dynamics of correlated subdiffusion and normal diffusion.

We analyze the dissipative dynamics of a particle governed by a two-dimensional generalized Langevin equation with coupled fractional Gaussian noise and white noise in its respective coordinates, assuming the lowest-order coupling form. Two situations are studied: In the first the particle is free from external force and in the second the particle is subject to a two-dimensional harmonic potential. We derive the general expressions for the mean values, variances, and velocity autocorrelation function and evaluate their temporal evolutions via the numerical Laplace inversion technique.