Publications by authors named "Yingtong Lv"
Article Synopsis
- The study presents a novel copper cluster-based metal-azolate framework (CuTz-1) that serves as an electrocatalyst for reducing CO to CO, promoting carbon neutrality.
- CuTz-1 demonstrated a faradaic efficiency (FE) of 62.7% and maintained performance over ten hours with minimal changes in current density and FE.
- The research highlights important changes in the Cu ion's structure during the electrochemical process, including increased Cu-N distance and decreased oxidation state, contributing to a better understanding of catalyst behavior.
[Antibody druggability screening process and evaluation strategy].
Sheng Wu Gong Cheng Xue Bao
February 2024
Since the approval of OKT3 as the first therapeutic monoclonal antibody in 1986, there has been rapid development in antibody technology and antibody drugs. Monoclonal antibodies, antibody fragments, bi (multi) specific antibodies, fusion proteins, nanobodies, and antibody-drug conjugates (ADCs) have been introduced and play a significant role in the treatment of oncology, hematology, immunology, respiratory, metabolic and other related diseases. The process of antibody drug discovery involves multiple rounds of biological function and druggability assessments to identify the best candidate sequences that are safe, effective, stable, and scalable.
View Article and Find Full Text PDFSodium Carbazolide and Derivatives as Solid-State Electrolytes for Sodium-Ion Batteries.
Angew Chem Int Ed Engl
June 2023
Article Synopsis
- - Replacing traditional liquid electrolytes with solid-state electrolytes (SSEs) in sodium-ion batteries can improve safety, but SSEs face challenges like low ionic conductivity and manufacturing difficulties.
- - Researchers developed sodium carbazolide (Na-CZ) and its THF-coordinated derivatives, achieving high sodium conductivities, particularly at 90°C, making them leading sodium conductors.
- - These materials demonstrate excellent interfacial stability with sodium electrodes during extensive cycling, and their ease of synthesis and low-cost production methods make them promising for practical battery applications.
Renal injury is the main adverse reaction of cisplatin, and many traditional Chinese medicines (TCMs) were proven active against renal toxicity. Here, an integrated metabolomics and network pharmacology strategy was proposed to discover active TCM ingredients for the alleviation of cisplatin nephrotoxicity. First, by interrogating the Human Metabolome Database (HMDB) we collected targets connected to 149 cisplatin nephrotoxicity-related metabolites.
View Article and Find Full Text PDFSaikosaponin d (SSd) is one of the main active ingredients in Radix Bupleuri. In our study, network pharmacology databases and metabolomics were used in combination to explore the new targets and reveal the in-depth mechanism of SSd. A total of 35 potential targets were chosen through database searching (HIT and TCMID), literature mining, or chemical similarity predicting (Pubchem).
View Article and Find Full Text PDFPharmacometabolomics has been already successfully used in toxicity prediction for one specific adverse effect. However in clinical practice, two or more different toxicities are always accompanied with each other, which puts forward new challenges for pharmacometabolomics. Gastrointestinal toxicity and myelosuppression are two major adverse effects induced by Irinotecan (CPT-11), and often show large individual differences.
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