Publications by authors named "Yingting Wei"
Article Synopsis
- - The study investigates the effectiveness of minimally-invasive 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating cervical high-grade squamous intraepithelial lesions (HSIL/CIN2) and identifies factors influencing treatment success.
- - A retrospective analysis of 69 patients showed significant links between unsuccessful treatment outcomes and conditions like current smoking and sleep disorders, but no significant factors were found for the clearance of high-risk HPV infection.
- - The findings indicate that smoking and sleep issues may hinder the regression of HSIL/CIN2 after ALA-PDT, suggesting that these factors should be considered when planning treatment for affected patients.
Alzheimer's disease is associated both with imbalances in Al production and changes in viscosity in cells. Their simultaneous measurement could therefore provide valuable insights into Alzheimer's disease pathology. Their simultaneous measurement would therefore be of great value in investigating the pathological mechanism of Alzheimer's disease.
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- Vaginal intraepithelial neoplasia (VaIN) is a vaginal condition linked to high-risk HPV infection, leading to cellular changes and potential cancer.* -
- The study compared the effectiveness and safety of CO laser treatment, photodynamic therapy (PDT), and a combination of both on patients with VaIN1 and HR-HPV infection, involving 75 participants.* -
- Results showed no significant differences in treatment outcomes between the groups, although PDT had fewer adverse effects compared to laser treatments, making it a potential preferred option for managing VaIN1.*
This study assessed the efficacy of ThinPrep cytologic test and human papillomavirus (HPV) co-test in cervical cancer screening during pregnancy. A cohort of 8,712 pregnant women from Ren Ji Hospital participated in the study. Among them, 601 (6.
View Article and Find Full Text PDFObjective: The purpose of this study was to identify the clinical characteristics of patients with high-grade squamous intraepithelial lesions (HSIL) with abnormal endocervical curettage (ECC) and to evaluate the efficacy of abnormal preoperative ECC in predicting recurrence after a loop electrosurgical excision procedure (LEEP).
Methods: We retrospectively analyzed a total of 210 cases of histological HSIL in female patients diagnosed using cervical biopsy and/or indiscriminating ECC, and these included 137 cases with normal ECC and 63 cases with abnormal ECC. We also collected preoperative information and data on postoperative human papillomavirus (HPV) and histological outcomes within 2 years.
Objective: To evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser pretreatment (Laser+ALA-PDT) on patients with cervical high-grade squamous intraepithelial lesions (HSILs).
Methods: A total of 114 patients treated by ALA-PDT or Laser+ALA-PDT at 3 centers were retrospectively reviewed. The effective rate, cure rate of lesions as well as high-risk human papillomavirus (HR-HPV) regression rate and persistent infection rate in the 2 groups were compared according to 3-6 month and 9-12 months follow-ups.
Background: Patients after hysterectomy are at higher risk for developing VaIN. However, there are no standard treatments for HPV infection and VaIN after hysterectomy and relative studies are limited. Thus we aim to evaluate the feasibility of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) for the treatment of persistent vaginal infection with high-risk HPV (HR-HPV) in post-hysterectomy patients.
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- A balance between immune cells and tumor cells is essential for fighting tumors, with tumor cells using immune escape mechanisms for survival.
- Tumor cells disrupt the activity of T cells, NK cells, and macrophages through various strategies, including altering surface antigens and expressing immunosuppressive factors.
- The paper reviews the mechanisms of immune escape in digestive system tumors to support the development of immunotherapy for gastrointestinal cancers.
Article Synopsis
- Research on HPV prevalence and women's awareness in Shanghai is limited, prompting a study involving 6,619 women aged 21-65 to assess risk factors and knowledge about HPV before vaccine introduction.
- The study found a 9.5% positivity rate for high-risk HPV, with factors such as education level, vaginitis, and family cancer history identified as significant independent risk factors for infection.
- Women with graduate-level education exhibited higher knowledge regarding cervical cancer and screening compared to others, and the overall HPV prevalence in Shanghai was lower than in other regions, possibly due to differences in demographics and lifestyle.
Clinical evaluation of a real-time optoelectronic device in cervical cancer screening.
Eur J Obstet Gynecol Reprod Biol
November 2021
Objective: Early screening and intervention are crucial for the prevention and treatment of cervical cancer. TruScreen is a real-time, intelligent, pathological diagnostic technology designed for cervical cancer screening. The aim of this study was to evaluate the clinical value of TruScreen in screening for cervical lesions.
View Article and Find Full Text PDFCharacterization of a complete mitochondrial genome of (Passeriformes: Turdidae).
Mitochondrial DNA B Resour
May 2021
Article Synopsis
- The study focuses on the mitochondrial genome of a species from the genus primarily found in China and Northeast Asia, with prior research analyzing over 20 related species.
- Researchers sequenced a complete mitochondrial DNA genome that is 16,737 bp long, which includes various genes essential for the organism's functions.
- The findings revealed close relationships within the genus and emphasized the mitogenome's importance for future studies in population genetics, conservation, and evolutionary relationships among bird families like Turdidae and Passeriformes.
The high mobility group protein B (HMGB) family (including HMGB1, HMGB2, HMGB3, and HMGB4) can regulate the mechanisms of DNA replication, transcription, recombination, and repair, and act as cytokines to mediate responses to infection, injury, and inflammation. HMGB1/2/3 has a high similarity in sequence and structure, while HMGB4 has no acidic C-terminal tail. Among them, HMGB3 can regulate the self-renewal and differentiation of normal hematopoietic stem cell population, but the decrease of its expression is easy to induce leukemia.
View Article and Find Full Text PDFBackground: Clinical studies have shown that celecoxib can significantly inhibit the development of tumors, and basic experiments and in vitro experiments also provide a certain basis, but it is not clear how celecoxib inhibits tumor development in detail.
Methods: A literature search of all major academic databases was conducted (PubMed, China National Knowledge Internet (CNKI), Wan-fang, China Science and Technology Journal Database (VIP), including the main research on the mechanisms of celecoxib on tumors.
Results: Celecoxib can intervene in tumor development and reduce the formation of drug resistance through multiple molecular mechanisms.