Publications by authors named "Yingtan Wang"
Article Synopsis
- Bipolar disorder (BD) is a serious mental illness that can be wrongly diagnosed or missed, causing problems for both people and society.
- The study looked at brain activity measured by EEG (a way to see how the brain works) in people with BD compared to healthy individuals and found that BD patients had unusual brain wave patterns, especially in delta, theta, beta, and gamma frequencies.
- The research emphasized that many factors, like age and medication, can affect the study results, so it's important to keep things consistent when studying BD.
Article Synopsis
- Major depressive disorder (MDD) is a leading cause of disability and is increasingly diagnosed, prompting research into objective biomarkers like EEG to help with detection and diagnosis.
- * The study compared the resting-state EEG of MDD patients and healthy controls under both eyes-open and eyes-closed conditions, focusing on functional connectivity using the phase locking value (PLV) across different brain regions and frequency bands.
- * Results indicated significant differences in PLV in certain brain areas between MDD patients and healthy controls, but no strong correlation was found between these differences and the severity of depression as measured by the Hamilton Depression Rating Scale.
Objectives: To explore the effect of escitalopram combined with aripiprazole on cognitive function in patients with major depressive disorder (MDD), and to evaluate the clinical efficacy of the combination therapy.
Method: A total of 70 patients with first-episode MDD were randomly divided into the study group or the control group, receiving escitalopram combined with aripiprazole (5 mg/day) or escitalopram monotherapy respectively for 8 weeks. The severity of illness was assessed by using the Hamilton Rating Scale for Depression (HAMD) at baseline, at the end of 4 and 8 week, and cognitive function was assessed by using the THINC integrated tool (THINC-it), the Wisconsin Card Sorting Test (WCST), and the Continuous Performance Test (CPT).
At present, no well-established biomarkers were ever found to distinguish unipolar depression and bipolar disorder (BD). This study aimed to provide a clearer comparison of UA levels between BD and major depressive disorder. Peripheral UA of 119 patients with BD in acute stage (AS) and 77 in remission stage (RS), and 95 patients with UD in AS and 61 in RS were measured, so were 180 healthy controls.
View Article and Find Full Text PDFMuch evidence shows that some , fifth edition (DSM-5)-defined unipolar depression (UD) with bipolarity manifests bipolar diathesis. Little is known about the cognitive profiles of patients with depression with bipolarity (DWB). The study aimed to investigate the differences in cognitive profiles among patients with bipolar depression (BD), major depressive disorder (namely, UD), and DWB.
View Article and Find Full Text PDFRationale: Piribedil is an orally active dopamine agonist that has been widely used for Parkinson disease (PD), with its partial D2/D3 agonistic functions and alpha2-adrenoreceptor antagonistic effects, piribedil has been proved to be efficacious in the relief of motor symptoms in PD, while it can also lead to impulse control disorders such as pathological gambling due to its dopamine agonistic effects.
Patient Concerns: A 28-year-old Chinese female patient with Parkinson disease and a history of taking piribedil finally developed pathological gambling and depressive episode.
Diagnoses: After a careful clinical observation and evaluation, the patient met the criteria of severe depressive episode and pathological gambling due to antiparkinson therapy.
Background: Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidants between schizophrenia patients and healthy controls.
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