Mitochondrial homeostasis plays a major role in the progression of chronic inflammatory bone loss which has a complex pathogenesis with unsatisfactory therapeutic efficiency. Recently, melatonin has been shown to recipient mitochondrial function and bone formation. However, the effects and underlying molecular mechanism of melatonin in chronic inflammatory bone loss remain unclear.
View Article and Find Full Text PDFIcariin has shown the potential to treat osteoarthritis (OA), but the specific mechanism still needs further exploration. Therefore, this study attempted to reveal the effect and mechanism of icariin on OA based on in vitro and in vivo experiments. In vivo, a mouse model of OA was established by cutting the anterior cruciate ligament, and 10 mg/kg icariin was given to mice orally.
View Article and Find Full Text PDFTo improve the electrocatalytic activity, carbon nanotubes (CNTs) were used to modify a titanium-supported tin-antimony anode (Ti/SnO-Sb). Compared to a Ti/SnO-Sb anode, the Ti/SnO-Sb-CNTs anode exhibited a higher oxygen evolution potential (1.62 V), smaller crystalline volume (71.
View Article and Find Full Text PDFBackground: The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA).
Material And Methods: We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain score/Kellgren-Lawrence (KL) grading system.