Neural oscillations during acupuncture imagery partially parallel that of real needling.

Introduction: Tasks involving mental practice, relying on the cognitive rehearsal of physical motors or other activities, have been reported to have similar patterns of brain activity to overt execution. In this study, we introduced a novel imagination task called, acupuncture imagery and aimed to investigate the neural oscillations during acupuncture imagery.

Methods: Healthy volunteers were guided to watch a video of real needling in the left and right KI3 (Taixi point).

Multi-scene visual hydrazine hydrate detection based on a dibenzothiazole derivative.

Hydrazine (NH) produced by industries is distributed into different environments, and seriously threatens ecology and human security. Hence, it is important to develop probes that detect NH in various environments. In this study, a novel NH fluorescent probe was prepared based on a dibenzothiazole derivative (DBTD).

Efficacy and Safety of Bifidobacterium Quadruple Viable Bacteria Combined with Mesalamine against UC Management: A Systematic Review and Meta-Analysis.

Objective: To systematically assess effectiveness and safety of Bifidobacterium quadruple viable bacteria combined with mesalamine against ulcerative colitis (UC) in the Asian population.

Methods: An electronic search was conducted in PubMed, Embase, Cochrane Library, CNKI, VIP, and Wanfang databases for a random collection of controlled trials of Bifidobacterium quadruple viable bacteria combined with mesalamine against UC. Following data screening and extraction, a Cochrane risk assessment tool was adopted to evaluate the quality of the included studies, and RevMan 5.

Clinical outcomes of PD-1/PD-L1 inhibitors in patients with advanced hepatocellular carcinoma: a systematic review and meta-analysis.

Purpose: Programmed death ligand 1(PD-L1)/programmed cell death-1(PD-1) inhibitors have shown promising efficacy in unresectable patients with advanced hepatocellular carcinoma (HCC), but the results are not consistent. Our goal was to evaluate the safety and efficacy of PD-L1/PD-1 inhibitors or plus anti-CTLA-4 antibody or anti-VEGF agents for the treatment of unresectable HCC.

Methods: Cochrane library, Embase, and PubMed were searched till August 2021.

Lysosome-targeting benzothiazole-based fluorescent probe for imaging viscosity and hypochlorite levels in living cells and zebrafish.

Viscosity and hypochlorite (OCl) play an important role in biological activities and may cause negative effects at abnormal levels. In this study, a novel lysosome-target fluorescent probe BDHA was obtained based on a benzothiazole derivative. Probe BDHA showed linear ranges of detection for viscosity from 1.

A mitochondria-targeted fluorescent probe for monitoring endogenous cysteine in living cells and zebrafish.

At the organelle level, pathogenesis due to abnormal concentrations of cysteine (Cys) is of great significance for the early diagnosis and treatment of related diseases. Generally speaking, organelle localization requires the participation of specific target groups, which increases the difficulty of synthesis. Herein, through simple synthesis, a novel biflavone derivative (BFD) that exhibits excited-state intramolecular proton transfer (ESIPT) was obtained and successfully located in mitochondria without target groups.

Aggregation-induced fluorescence probe for hypochlorite imaging in mitochondria of living cells and zebrafish.

Hypochlorite is an important active oxygen species formed in living organisms, and rapid and highly sensitive detection of trace hypochlorite is of great significance for understanding the mechanism of diseases caused by abnormal hypochlorite concentrations at an early stage. Although aggregation-induced emission (AIE) probes are highly important for analyte de-tection in living organisms, there is a lack of AIE probes for hypochlorite detection. In this study, two AIE probes based on benzothiazole derivatives (BTD-1 and BTD-2) were designed and synthesized.

A mitochondria-targeted fluorescent probe for hypochlorite sensing and its application in bioimaging.

A coumarin-diaminomaleonitrile derivative (C-DAN) was designed and prepared. Upon addition of hypochlorite (OCl-), the fluorescence emission peak of C-DAN at 475 nm was gradually enhanced with a rapid response (within 5 s); meanwhile, the color of the solution changed from dark red to bright yellow which can be observed with the naked eye. Furthermore, owing to its advantages including high selectivity, sensitivity, and low toxicity, our C-DAN probe has been applied for detecting OCl- in living cells and zebrafish, indicating it is an ideal tool for biological applications.