Publications by authors named "Yingshuai Fang"
Pre-metastatic niche: formation, characteristics and therapeutic implication.
Signal Transduct Target Ther
September 2024
Article Synopsis
- Distant metastasis significantly increases cancer mortality and complicates surgical outcomes.
- The formation of a "pre-metastatic niche" is crucial for cancer cells to spread, influenced by tumor-derived factors, extracellular vesicles, and circulating tumor cells.
- The review highlights cellular and molecular elements involved in niche formation across various organs and discusses potential therapeutic interventions targeting these components and associated signaling pathways.
Article Synopsis
- * The review discusses various innovative strategies to engineer macrophages for cancer immunotherapy, including drug delivery systems, chimeric antigen receptor therapies, and treatments combining macrophages with bacterial components.
- * These engineered macrophage strategies aim to improve treatment effectiveness against challenging solid tumors, especially those that are drug-resistant, and could transform current approaches to cancer treatment.
Background: Cancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate in tumours, serves as frontline cells in response to tumour progression owing to the rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment a promising field in cancer therapy.
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