Publications by authors named "Yingrong Zhu"
Purpose Of Review: This review aims to discuss pathophysiology, diagnosis, clinical presentation, and treatment of chemotherapy-induced peripheral neuropathy. Agent-specific presentation and pathophysiology is also being discussed.
Recent Findings: As new systemic oncological treatments continue to be developed, the number of cancer survivors continues to grow.
Background And Objective: Little is known about trajectories of recovery 12 months after hospitalization for severe COVID-19.
Methods: We conducted a prospective, longitudinal cohort study of patients with and without neurologic complications during index hospitalization for COVID-19 from March 10, 2020, to May 20, 2020. Phone follow-up batteries were performed at 6 and 12 months after COVID-19 onset.
Article Synopsis
- A study was conducted to analyze the long-term outcomes, specifically 6-month results, of patients who were hospitalized for COVID-19, particularly focusing on those who experienced neurological complications during their stay.
- Out of 606 patients with neurological issues, 395 survived and were compared to a matched group without such complications; results showed that 91% had at least one abnormal outcome six months later, including difficulties with daily activities, cognition, and mental health.
- Patients with neurological complications had worse functional outcomes, indicating they were less likely to return to normal activities and had greater impairments compared to the control group, highlighting the severe impact of neurological issues following COVID-19 hospitalization.
Background: It is essential to investigate the experiences behind why adolescents start and continue to self-harm in order to develop targeted treatment and prevent future self-harming behaviours.
Aims: The aims of this study are to understand the motivations for initiating and repeating nonfatal self-harm, the different methods used between first-time and repeated self-harm and the reasons that adolescents do not seek help from health services.
Methods: Adolescents with repeated nonfatal self-harm experiences were recruited to participate in individual, semi-structured qualitative interviews.
Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversible inhibition of the immunoproteasome β5i subunit while sparing the constitutive β5c subunit. Here we report β5i-selective inhibition by asparagine-ethylenediamine (AsnEDA)-based compounds and present the high-resolution cryo-EM structural analysis of the human immunoproteasome.
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