SPMLD: A skin pathological image dataset for non-melanoma with detailed lesion area annotation.

Skin tumors are the most common tumors in humans and the clinical characteristics of three common non-melanoma tumors (IDN, SK, BCC) are similar, resulting in a high misdiagnosis rate. The accurate differential diagnosis of these tumors needs to be judged based on pathological images. However, a shortage of experienced dermatological pathologists leads to bias in the diagnostic accuracy of these skin tumors in China.

Role of hippo pathway and cuproptosis-related genes in immune infiltration and prognosis of skin cutaneous melanoma.

Melanoma is the most lethal type of skin cancer with an increasing incidence. Cuproptosis is the most recently identified copper-dependent form of cell death that relies on mitochondrial respiration. The hippocampal (Hippo) pathway functions as a tumor suppressor by regulating Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ) activity.

Artificial Intelligence-Aided Recognition of Pathological Characteristics and Subtype Classification of Superficial Perivascular Dermatitis.

Superficial perivascular dermatitis, an important type of inflammatory dermatosis, comprises various skin diseases, which are difficult to distinguish by clinical manifestations and need pathological imaging observation. Coupled with its complex pathological characteristics, the subtype classification depends to a great extent on dermatopathologists. There is an urgent need to develop an efficient approach to recognize the pathological characteristics and classify the subtypes of superficial perivascular dermatitis.

Study of melanocyte density and epidermal thickness in vulvar lichen sclerosus lesions.

Objective: This study aimed to analyze changes in melanocyte density and epidermal thickness in vulvar lichen sclerosus (VLS).

Methods: Vulvar skin tissues were collected from 15 VLS female patients in Beijing Hospital, classified into early (n = 7) and late VLS (n = 8) groups according to pathological manifestations. Melanocyte density and full epidermal and cell-layer (from the bottom of the stratum corneum to that of the basal layer) thickness were calculated using an image analysis software.

Study of Langerhans cells and T lymphocytes in vulvar lichen sclerosus lesions.

Background: The aetiology and pathogenesis of vulvar lichen sclerosus (LS), a chronic inflammatory disease, is not completely clear. It has been found that local cellular immune abnormalities play an important role in the immune mechanism of LS, mainly characterised by abnormal numbers of Langerhans cells in the epidermis and abnormal numbers of dermal T lymphocytes.

Objective: To evaluate the densities of Langerhans cells and T-lymphocyte subpopulations in vulvar LS.

Topical photodynamic therapy with 5-aminolevulinic acid for cervical high-risk HPV infection.

Objective: To investigate the clinical efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for cervical high-risk HPV (HR-HPV) infection.

Methods: In this prospective study, a total of 76 patients with persistent cervical HR-HPV infection were randomly divided into two groups. The treatment group (39 patients) received three treatments of ALA-PDT at two-week intervals.

In vitro antifungal activity of micafungin and caspofungin against dermatophytes isolated from China.

Aims: The aims of this study are to investigate the in vitro activities of micafungin and caspofungin that are two new echinocandin antifungal drugs against clinically isolated dermatophytes in China and to define MEC (minimal effective concentration) as the reading endpoints of this study in accordance with (Clinical and laboratory Standards Institute) CLSI M38-A2 reference.

Methods: Minimal effective concentrations (MECs) of micafungin and caspofungin for 82 dermatophyte strains were determined according to CLSI (formerly NCCLS) M38-A2 broth microdilution methods.

Results: (1) The MEC(90s) of micafungin for Trichophyton violaceum and Trichophyton tonsurans were 0.