Publications by authors named "Yingqi Liu"

Mucosal vaccines can generate localized mucosal immunity, effectively preventing initial pathogen infection and providing more effective protection. Oral vaccines are an attractive option for inducing mucosal immunity. The yeast cell wall, primarily composed of natural β-1,3-d glucan, can be recognized by the apical membrane receptor, dectin-1, which has a high expression on macrophages and intestinal M cells.

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Early diagnosis of tumors allows effective treatment of primary cancers through localized therapeutic interventions. However, developing diagnostic tools for sensitive, simple, and early tumor (especially less than 2 mm in diameter) detection remains a challenge. Herein, we presented a biomarker-activatable nanoprobe that enabled a near-infrared (NIR) photothermally amplified signal for fluorescence imaging and urinalysis of tumor.

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Chlamydomonas reinhardtii, a prominent chassis in synthetic biology, faces limitations in regulating the expression of exogenous genes. A destabilization domain (DD)/Shield-1 system, originally derived from mammals, offers a ligand-dependent control of stability, making it a valuable tool. This system utilises the destabilization domain to induce rapid degradation of target protein unless stabilised by Shield-1, a synthetic ligand.

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Cellular senescence, a hallmark of aging, involves a stable exit from the cell cycle. Senescent cells (SnCs) are closely associated with aging and aging-related disorders, making them potential targets for anti-aging interventions. In this study, we demonstrated that human embryonic stem cell-derived exosomes (hESC-Exos) reversed senescence by restoring the proliferative capacity of SnCs in vitro.

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In-situ tumor vaccination remains challenging due to difficulties in the exposure and presentation of tumor-associated neoantigens (TANs). In view of the central role of lipid metabolism in cell fate determination and tumor-immune cell communication, here we report a photo-controlled lipid metabolism nanoregulator (PLMN) to achieve robust in-situ adjuvant-free vaccination, which is constructed through hierarchically integrating photothermal-inducible arachidonate 15-lipoxygenase (ALOX15)-expressing plasmids, cypate and FIN56 into cationic liposomes. Near-infrared light (NIR) stimulation triggers on-demand ALOX15 editing and causes excessive accumulation of downstream pro-ferroptosis lipid metabolites.

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Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting catalytic immunotherapy by modulating the immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates a thorough understanding of the properties and underlying mechanisms of tumor-targeted catalytic materials.

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Article Synopsis
  • A revision of the Australian species of the genus Brachysandalus identifies a total of 21 species, including nine new ones introduced in the study.
  • The researchers provide updated descriptions for both the genus and all previously known Australian species, with designated lectotypes for several key species.
  • The study clarifies taxonomic relationships, including removing some species from synonymy and providing a species key for identification.
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  • - The development of effective catalysts is crucial for Li-CO batteries due to their high energy barriers, slow reaction rates, and complex environments, with transition metal oxides like NiCoO showing great potential.
  • - This study focuses on how adding Ni to CoO affects local spin states, enhancing electron transfer to CO and optimizing active sites for forming small LiCO crystals, which contributes to better battery performance.
  • - Results demonstrate that NiCoO achieves an overpotential of 0.72 V and around 70% energy efficiency after 500 hours, providing valuable insights into the spin states' role in CO reactions for high-performance battery development.
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Ferroptosis is a lipid peroxidation-driven cell death route and has attracted enormous interest for cancer therapy. Distinct from other forms of regulated cell death, its process is involved with multiple metabolic pathways including lipids, bioenergetics, iron, and so on, which influence cancer cell ferroptosis sensitivity and communication with the immune cells in the tumor microenvironment. Development of novel technologies for harnessing the ferroptosis-associated metabolic regulatory network would profoundly improve our understanding of the immune responses and enhance the efficacy of ferroptosis-dependent immunotherapy.

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The N7-methylguanosine (m7G) methyltransferase Mettl1 has been recently implicated in cardiac repair and fibrosis. In this study we investigated the role of Mettl1 in mouse cardiomyocytes injury and the underlying mechanisms. Cardiac ischemia/reperfusion (I/R) I/R model was established in mice by ligation of the left anterior descending coronary artery (LAD) for 45 min followed by reperfusion for 24 h.

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  • PEGDA microneedles (MNs) are hydrogel devices designed for controlled drug delivery, but traditional crosslinking agents can pose biosafety issues.
  • The researchers developed a new series of TP-X MNs by combining two PEGDA polymers with different molecular weights, enabling the adjustment of crosslinking density without harmful agents.
  • Ex vivo tests showed that TP-X MNs have a controllable and sustained drug release profile, and the study also introduced a dual-layer PEGDA MN for precise drug loading and release customization.
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Background: Denosumab is authorized to treat several diseases, including cancer and bone disorders. Nevertheless, its use in clinical practice has been affected by safety concerns. The work retrospectively investigated adverse events (AEs) of denosumab to better understand toxicities.

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  • Mucosal vaccines can provide immune protection at both systemic and infection sites, but face challenges from mucosal barriers.
  • Researchers developed exosomes modified with IgG fragments to help deliver the SARS-CoV-2 receptor-binding domain across mucosal layers effectively.
  • The modified exosomes induced strong antibody and T cell responses in animal lungs, offering significant protection against SARS-CoV-2 pseudovirus, suggesting a promising new approach for respiratory vaccines.
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Catalytic reactions mainly depend on the adsorption properties of reactants on the catalyst, which provides a perspective for the design of reversible lithium-carbon dioxide (Li-CO) batteries including CO reduction (CORR) and CO evolution (COER) reactions. However, due to the complex reaction process, the relationship between the adsorption configuration and CORR/COER catalytic activity is still unclear in Li─CO batteries. Herein, taking CoS as a model system, nickel (Ni substitution in the tetrahedral site to activate cobalt (Co) atom for forming multiatom catalytic domains in NiCoS is utilized.

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The sluggish CO reduction and evolution reaction kinetics are thorny problems for developing high-performance Li-CO batteries. For the complicated multiphase reactions and multielectron transfer processes in Li-CO batteries, exploring efficient cathode catalysts and understanding the interplay between structure and activity are crucial to couple with these pendent challenges. In this work, we applied the CoS as a model catalyst and adjusted its electronic structure by introducing sulfur vacancies to optimize the d-band and p-band centers, which steer the orbital hybridization and boost the redox kinetics between Li and CO, thus improving the discharge platform of Li-CO batteries and altering the deposition behavior of discharge products.

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  • CAN-FD is a version of the standard Controller Area Network that lacks security measures, making it susceptible to attacks, and anomaly detection can help enhance its security.
  • The proposed intrusion detection model consists of two key components: an Anomaly Data Detection Model (ADDM) using LSTM for detecting unusual patterns, and an Anomaly Classification Detection Model (ACDM) enhanced with an attention mechanism to classify the anomalies effectively.
  • The model was tested with two datasets, including one based on actual vehicle attack scenarios, and showed improvements in detection accuracy of 1.44% compared to existing LSTM methods and 1.01% against CNN-LSTM methods, demonstrating its effectiveness in the field of anomaly detection.
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Breast cancer remains the most common malignant carcinoma among women globally and is resistant to several therapeutic agents. There is a need for novel targets to improve the prognosis of patients with breast cancer. Bioinformatics analyses were conducted to explore potentially relevant prognostic genes in breast cancer using The Cancer Genome Atlas (TCGA) and The Gene Expression Omnibus (GEO) databases.

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Programmed cell death 1 (PD-1) inhibitor revives the killing effect of immune cells to prevent tumor progression. The present study aimed to evaluate the efficacy and safety of first-line PD-1 inhibitor + chemotherapy vs. standard treatment in recurrent or metastatic (R/M) oral squamous cell carcinoma (OSCC).

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Inhaling microplastics (MPs) and nanoplastics (NPs) in the air can damage lung function. Xenobiotics in the body can cause endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) activation alleviates ER stress. Degradation of unfolded or misfolded proteins is an important pathway for recovering cellular homeostasis.

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Cardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1-catalyzed RNA N7-methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis. This study aims to elucidate the role of Mettl1 and the mechanism underlying non-ischemic cardiac hypertrophy and HF.

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Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multiple etiological factors. Immune disorder contributes to SLE development and is an important clinical manifestation of SLE patients. Immune dysfunction is characterized by abnormal of B cells, T cells, monocyte-macrophages and dendritic cells (DCs), in both quantity and quality.

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Alphaherpesvirus pseudorabies virus (PRV) causes severe economic losses to the global pig industry and has garnered increasing attention due to its broad host range including humans. PRV has developed a variety of strategies to antagonize host antiviral innate immunity. However, the underlying mechanisms have not been fully elucidated.

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A variety of neurological and psychiatric disorders have recently been shown to be highly associated with the abnormal development and function of oligodendrocytes (OLs) and interneurons. OLs are the myelin-forming cells in the central nervous system (CNS), while interneurons are important neural types gating the function of excitatory neurons. These two types of cells are of great significance for the establishment and function of neural circuits, and they share similar developmental origins and transcriptional architectures, and interact with each other in multiple ways during development.

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Article Synopsis
  • Cancer stem cells (CSCs) with activated STAT3 play a crucial role in driving liver cancer (hepatocellular carcinoma or HCC), making them a significant target for treatment.
  • A new strategy utilizing a PROTAC-based approach has been developed to degrade STAT3, which not only inhibits CSC growth but also enhances the body's immune response against HCC.
  • The PROTAC prodrug is designed for targeted delivery using modified liposomes, and it works by taking advantage of elevated ROS levels in CSCs, effectively reshaping the tumor environment to support anti-cancer immunity.
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