Publications by authors named "Yingnan Xu"
Objective: To report four cases of microsporidial keratoconjunctivitis (MKC) from The Affiliated Eye Hospital of Nanjing Medical University (from May 2023 to October 2024) and to aid ophthalmologists in diagnosing and treating MKC, as MKC has been increasingly reported in Asian healthy individuals but not much in Mainland China.
Methods: Four patients with MKC were studied. Demographic information, symptoms, and clinical data were collected.
Article Synopsis
- A study conducted in ten Chinese cities from 2013 to 2023 analyzed over 418,000 outpatient visits for conjunctivitis in children, revealing inconclusive evidence regarding the impact of ambient gaseous pollutants on the condition.
- The research found that higher daily concentrations of carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone were associated with increases in pediatric conjunctivitis visits, with boys and younger children being more affected.
- The study suggests implementing public health interventions to mitigate the risks associated with air pollution, especially during the summer months when associations were stronger.
The Aggregation Units of J-Aggregates: Transitioning from Monomers to Hydrogen-Bonded Dimers.
J Phys Chem Lett
September 2024
Article Synopsis
- J-aggregates, which are special molecular structures formed by stacking, have gained popularity in scientific research.
- New findings indicate that these aggregates are made not just of individual molecules (monomers) but also include groups of molecules (aggregation units) held together by weak noncovalent bonds.
- Researchers developed three unique PPCy dyes that can create hydrogen-bonded dimers, which serve as aggregation units, and discovered that the resulting J-aggregates have enhanced near-infrared fluorescence with distinct optical properties.
Advanced photosensitizers for high-performance fluorescence imaging-guided photothermal therapy demand excellent near-infrared (NIR) brightness [molar absorption coefficient (ε) × quantum yield (QY)] and exceptional photothermal performance [ε × photothermal conversion efficiency (PCE)]. However, integrating high brightness and potent photothermal performance within a single molecule faces a formidable challenge. This article proposes a method to address this issue by preparing J-aggregate nanoparticles (NPs) using molecules with high ε.
View Article and Find Full Text PDFTransfer RNA-derived fragments (tRFs) represent a novel class of non-coding RNA transcripts that possess specific biological functions. However, the involvement of tRFs in retinal microvascular diseases remains poorly understood. In this study, we aimed to reveal whether modulation of tRF-30 expression could attenuate pathological retinal neovascular diseases.
View Article and Find Full Text PDFObjective: Oxidative stress-induced retinal neurodegenerative changes are among the pathological alterations observed in diabetic retinopathy. Resveratrol (RSV), a polyphenolic compound with diverse pharmacological effects, has shown preventive qualities in several neurodegenerative illnesses, including anti-inflammatory, anti-aging, and antioxidant benefits. However, its therapeutic efficacy in diabetic retinal neurodegeneration has not yet been thoroughly elucidated.
View Article and Find Full Text PDFMyopia has become an important public health problem to be solved urgently. Posterior chamber phakic implantable Collamer lens (ICL) implantation is one of the latest and safest products for myopia correction worldwide. This prospective cross-sectional case series aimed to observe changes in the macular retinal thickness, retinal nerve fiber layer (RNFL) thickness of para-optic disk region, and blood flow density after posterior ICL implantation in patients with high myopia using optical coherence tomography angiography (OCTA).
View Article and Find Full Text PDFPurpose: To compare outcomes of deep anterior lamellar keratoplasty (DALK) and corneal cross-linking (CXL) in patients with advanced keratoconus, with the primary aim of assessing CXL as a potential therapeutic alternative.
Study Design: Retrospective, multi-center, comparative study.
Methods: Patients with advanced keratoconus (maximum keratometry reading (K-max) > 58D, best spectacle-corrected visual acuity worse than 0.
Aim: To evaluate the etiologies, management, and outcomes of pediatric traumatic cataract in eastern China.
Methods: Pediatric traumatic cataract were reviewed for demographic information, type of injury, mode of injury, time of injury, interval between injury and first visiting doctors, hospital of first visiting, surgeries, complications and prognosis.
Results: A total of 117 eyes of 117 patients (96 boys and 21 girls) with unilateral injuries (66 right and 51 left eyes) were included in the study.