Shear force-ROS sequential responsive drug delivery system for improving cerebral thrombosis microcirculation and neurological function.

The ischemic strokes seriously threaten human health with high incidence and disability rates. Cerebral embolism and impaired brain function are the two major clinical features of this disease. Therefore, rapid restoration of cerebral blood supply and synchronous improvement of impaired neurological function is the key to treating strokes.

Laser-enzyme dual responsive liposomes to regulate autophagy in synergy with phototherapy for melanoma treatment.

Phototherapy can cause autophagy while killing tumour cells, leading to tumour recurrence and metastasis. Here, we constructed a laser and enzyme dual responsive nanodrug delivery system Tf-Te@CTSL-HCQ (TT@CH) to precisely regulate autophagy in synergy with phototherapy to inhibit the proliferation and metastasis of melanoma. Firstly, transferrin (Tf) was used as a nanoreactor to synthesise phototherapy agent Tf-Te by the biological template mineralisation method.

autophagy regulation in synergy with phototherapy for breast cancer treatment.

Autophagy is an important factor in reducing the efficacy of tumor phototherapy (including PTT and PDT). Accurate regulation of autophagy in tumor cells is a new strategy to improve the anti-tumor efficiency of PTT/PDT. This project intended to construct a tumor-activated autophagy regulator to efficiently block PTT/PDT-induced autophagy and realize synergistic sensitization to tumor phototherapy.

Restoration of Spatially Variant Blurred Images with Wide-Field Telescope Based on Deep Learning.

The wide-field telescope is a research hotspot in the field of aerospace. Increasing the field of view of the telescope can expand the observation range and enhance the observation ability. However, a wide field will cause some spatially variant optical aberrations, which makes it difficult to obtain stellar information accurately from astronomical images.

Impact of terminal tip location of midline catheters on catheter-related complications and indwelling duration in elderly patients.

Aim: To investigate the relationship between the position of the midline catheter tip and the frequency and type of complications associated with its placement.

Design: A cohort study was performed on patients between May 2018 and December 2021 who underwent midline catheter placement at our institution. Patients were divided into two groups, superficial implementation and deep implementation, based on the midline catheter tip location relative to the clavicle.