Publications by authors named "Yingling Wen"
Immunometabolism is critical in the regulation of immunity and inflammation; however, the mechanism of preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) in the glycolysis branching pathway is specifically downregulated by NF-κB signaling during innate immune activation via tristetraprolin (TTP)-mediated mRNA decay. As a result, its substrate S-D-lactoylglutathione (SLG) accumulates in the cytosol and directly induces D-lactyllysine modification of proteins.
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- Chronic inflammation is a key player in obesity-related issues like insulin resistance and cardiovascular disease, and is influenced by imbalances in immune cell types.
- Research shows that knockout of the Toll-like receptor 4 (TLR4) in young mice prevents obesity from a high-fat diet, but in older mice, it leads to spontaneous obesity despite a normal diet.
- The study found that TLR4 knockout triggers chronic low-grade inflammation through the TRIF/IRF3 pathway, which affects immune cell balance and promotes obesity, suggesting potential strategies for obesity prevention.
Accumulating evidence has shown that dietary zinc deficiency (ZD) increases the risk of various cancers including esophageal and gastric cancer. However, the role of ZD in colon tumorigenesis is unknown and the related mechanisms need to be investigated. mice, widely used to mimic the spontaneous process of human intestinal tumor, were used to construct a ZD mice model in this study.
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