Enhancing 5-Hydroxymethylfurfural Production from Fructose Using Triethylbenzylammonium Chloride-Based Acidic Deep Eutectic Solvents: Optimization and Acidity Impact.

5-Hydroxymethylfurfural (5-HMF) is an important biomass-based platform compound that links biomass feedstocks with petrochemical refinery products. In this work, we developed a novel approach using triethylbenzylammonium chloride (TEBAC)-based acidic deep eutectic solvents (ADESs) to synthesize 5-HMF through the dehydration of fructose. Our approach demonstrates significant improvements in both 5-HMF yield and process efficiency compared to conventional solvent systems.