Development and Road Performance Verification of Aggregate Gradation for Large Stone Asphalt Mixture.

The pavement base and subbase are the main load-bearing structures of asphalt pavement, and their materials need to have sufficient bearing capacity. Therefore, in the development of LSAM-50 mixtures with higher bearing capacity, after significant research and engineering practice, conventional particle size asphalt mixtures have formed their own excellent mineral gradation and have been incorporated into relevant specifications, while LSAM-50 mixtures, including mineral gradation, have not been involved in related research and engineering applications. According to the strength composition mechanism of asphalt mixtures, under the same circumstances of asphalt, due to the large nominal maximum particle size of LSAM-50 and the small amount of asphalt used, the strength of mineral grading is more important than that of asphalt, which is one of the key issues to be solved in the research of LSAM-50 mixtures.

The Effect of Low-Frequency Electrical Stimulation Combined With Anus Lifting Training on Urinary Incontinence After Radical Prostatectomy in a Chinese Cohort.

To evaluate the clinical efficacy of pelvic floor low-frequency electrical stimulation combined with anus lifting training in the treatment of urinary incontinence after radical prostatectomy in a Chinese cohort. Fifty-five patients with urinary incontinence after radical prostatectomy were randomly divided into treatment group and control group. Patients in control group received only anus lifting training therapy, while treatment group combined with pelvic floor low-frequency electrical stimulation.

Regulating effect of virtual reality restorative environment on prefrontal cortex dysfunction after night shifts in medical staff: an fNIRS study protocol for a randomized controlled trial in Dalian, China.

Background: Night shift work-related disturbed biological rhythm and insufficient sleep affect the functioning of brain activity and thus impair cognitive performance and mood state, which potentially leads to negative and even devastating results for both individuals and patients. A virtual reality (VR)-based restorative environment has shown to be an effective new technique to reduce stress and improve cognitive performance, but little is known about its mechanism of improving neuronal activity and connectivity.

Methods: This is a randomized, controlled, single-center clinical trial.

A novel DNA methylation signature to improve survival prediction of progression-free survival for testicular germ cell tumors.

This study aimed to develop a nomogram for predicting the progression-free survival (PFS) of testicular germ cell tumors (TGCT) patients based on DNA methylation signature and clinicopathological characteristics. The DNA methylation profiles, transcriptome data, and clinical information of TGCT patients were obtained from the Cancer Genome Atlas (TCGA) database. Univariate Cox, lasso Cox, and stepwise multivariate Cox regression were applied to identify a prognostic CpG sites-derived risk signature.

Total Synthesis of (-)-Levesquamide.

The total synthesis of levesquamide, a natural product with an unprecedented pentasubstituted pyridine-isothiazolinone skeleton, has been accomplished from kojic acid for the first time. The key features of the synthesis include a Suzuki coupling reaction between bromopyranone and oxazolyl borate fragments, a copper-mediated introduction of a thioether, a mild hydrolysis of a pyridine 2--methoxyamide, and a Pummerer-type cyclization of a -butyl sulfoxide to form the key pyridine-isothiazolinone unit of the natural product.

Improvement in Mung Bean Peptide on High-Fat Diet-Induced Insulin Resistance Mice Using Untargeted Serum Metabolomics.

This study aimed to elucidate the potential regulatory mechanism of mung bean peptides (MBPs) on glucolipid metabolism in insulin-resistant mice induced by high-fat diet (HFD) using untargeted serum metabolomics, enzyme linked immunosorbent assay (ELISA), intraperitoneal injection glucose tolerance test (IPGTT), insulin tolerance test (IPITT), and hematoxylin-eosin staining (H&E). The regulatory effect of MBPs for alleviating insulin resistance was studied by measuring body weight, fasting blood glucose (FBG) and serum insulin levels, C-Peptide levels, inflammatory and antioxidant factors, and histopathological observation of C57BL/6 mice. The experimental results showed that dietary intervention with MBPs (245 mg/kg/d) for 5 weeks significantly relieved insulin resistance in HFD mice.

Ionogel-Based Membranes for Safe Lithium/Sodium Batteries.

Alkali (lithium, sodium)-based second batteries are considered one of the brightest candidates for energy-storage applications in order to utilize the random and intermittent renewable energy to achieve carbon neutrality. Conventional lithium/sodium batteries containing liquid organic electrolytes are vulnerable to electrolytes leakage and even combustion, which hinders their large-scale and reliable application. All-solid-state electrolytes which are considered to have better safety have been developed in recent years.

Research on Mechanical Properties and Influencing Factors of Cement-Graded Crushed Stone Using Vertical Vibration Compaction.

To study the mechanical properties of cement-graded crushed stone for use in the transition sections of intercity railways, the growth laws governing unconfined compressive strength, splitting strength and resilience modulus of cement-graded crushed stone and their influencing factors were studied by the vertical vibration compaction method (VVCM). The strength growth equations of cement-graded crushed stone are proposed, and strength prediction equations are established. The research shows the unconfined compressive strength, splitting strength and resilience modulus of cement-graded crushed stone with a strong interlocked skeleton density type (VGM-30) are significantly enhanced to 20, 20 and 17% higher, respectively, than those of standard cement-graded crushed stone.

Laboratory evaluation of the effect of compaction method and compaction work on the performance of SMA-13 mixture.

The influence of compaction methods such as the Marshall compaction method (MCM), vibration compaction method (VCM) and gyration compaction method (GCM), on the performance of stone mastic asphalt (SMA-13) mixture has yet to be explored. Therefore, to compare the influences of compaction methods and work on the physical and mechanical properties of SMA-13 mixture, the volume parameters, mechanical properties, and gradation changes of SMA-13 mixture specimens prepared under different vibration compaction times, Marshall double-compaction numbers, and gyration compaction numbers were studied. The compaction method for SMA-13 mixture design was also proposed under the principle of optimum properties.

Total synthesis of (±) commiphoranes C-D and their epimers.

(±) Commiphorane C, (±) commiphorane D, and their two isomers were synthesized through a linear synthesis strategy in 14 steps. Key features of the strategy include the construction of the relative configurations of C-5 and C-6 aldehyde crotylation followed by the Mitsunobu reaction and ring A an intramolecular Aldol reaction. The biological evaluation revealed that (±) commiphorane C and (±) isomer-1 significantly attenuated the overproduction of fibronectin, collagen I, and α-SMA in TGF-β1-induced rat renal proximal tubular cells.

Numerical investigation of the plastic deformation behaviour of graded crushed stone.

A numerical model of the dynamic triaxial test of graded crushed stone was established based on DEM (Discrete Element Method) to study its dynamic characteristics. The influence of test conditions on simulation results was analysed through numerical simulation. A method for determining the test conditions was proposed, and the reliability of the simulation was verified.

Urinary Exosomes Diagnosis of Urological Tumors: A Systematic Review and Meta-Analysis.

Purpose: Exosomes could be released directly into the urine by the urological tumoral cells, so testing urinary exosomes has great potential for non-invasive diagnosis and monitor of urological tumors. The objective of this study is to systematically review and meta-analysis of urinary exosome for urological tumors diagnosis.

Materials And Methods: A systematic review of the recent English-language literature was conducted according to the PRISMA statement recommendations (CRD42021250613) using PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases up to April 30, 2021.

Meta-Analysis of the Diagnostic Value of Cell-free DNA for Renal Cancer.

Cell-free DNA (cf-DNA) has been reported to represent a suitable material for liquid biopsy in the diagnosis and prognosis of various cancers. We performed a meta-analysis of published data to investigate the diagnostic value of cf-DNA for renal cancer (RCa). Systematic searches were conducted using Pubmed, Embase databases, Web of Science, Medline and Cochrane Library to identify relevant publications until the 31st March 2021.

Development and Performance Evaluation of a High-Permeability and High-Bonding Fog-Sealing Adhesive Material.

Herein, the effects of the contents of emulsified asphalt, waterborne epoxy resin emulsion, and curing agent on the permeability, bond shear strength, water stability, and aging resistance of epoxy-emulsified asphalt were studied. A formulation of epoxy-emulsified asphalt as a fog-sealing adhesive material was recommended, and a comparison between the fabricated adhesive material and a traditional Chinese fog-sealing adhesive material was conducted to verify the technical performance of the new material. In addition, the strength formation mechanism of the epoxy-emulsified asphalt was revealed via microcosmic analysis.

Deterioration characteristics of cement-improved loess under dry-wet and freeze-thaw cycles.

The effects of cement dosage, compaction coefficient, molding method (vertical vibration method and static pressure method), and dry-wet and freeze-thaw cycles on the mechanical strength of cement-improved loess (CIL) were studied to reveal its strength degradation law under dry-wet and freeze-thaw cycles. Results show that when using the vertical vibration molding method, the strength degradation effect of CIL can be improved by increasing the cement dosage and compaction coefficient; however, it is not obvious. Under the action of dry-wet cycle, damages, such as voids and cracks of CIL, develop continuously.

Total Synthesis of the Proposed Structure of Characellide B.

We achieved the total synthesis of the proposed structure of characellide B, a novel lipoglycotripeptide. Comparison of the data for the synthetic compound with those for the natural product indicated some possible errors in the original structural assignment. Furthermore, we synthesized the other four stereoisomers, focusing on the d-Asp-d--Thr fragment, to determine the actual structure of characellide B.

Precisely Tunable T-NbO Nanotubes via Atomic Layer Deposition for Fast-Charging Lithium-Ion Batteries.

The demand for fast-charging of lithium-ion batteries (LIBs) in modern electric transportation and wearable electronics is rapidly growing. However, commercially available graphite anodes still suffer from slow kinetics of lithium-ion diffusion and severe safety concerns of lithium plating when achieving the fast-charging goal. Here, it is demonstrated that the Li-ion diffusion kinetics of orthorhombic NbO nanotubes (T-NbO NTs) is enhanced by atomically precise manufacturing of nanoarchitectures.

Architectural Engineering Achieves High-Performance Alloying Anodes for Lithium and Sodium Ion Batteries.

Tremendous efforts have been dedicated to the development of high-performance electrochemical energy storage devices. The development of lithium- and sodium-ion batteries (LIBs and SIBs) with high energy densities is urgently needed to meet the growing demands for portable electronic devices, electric vehicles, and large-scale smart grids. Anode materials with high theoretical capacities that are based on alloying storage mechanisms are at the forefront of research geared towards high-energy-density LIBs or SIBs.

Investigation on cement-improved phyllite based on the vertical vibration compaction method.

The vertical vibration compaction method (VVCM), heavy compaction method and static pressure method were used to form phyllite specimens with different degrees of weathering. The influence of cement content, compactness, and compaction method on the mechanical properties of phyllite was studied. The mechanical properties of phyllite was evaluated in terms of unconfined compressive strength (Rc) and modulus of resilience (Ec).

Discovery of CAPE derivatives as dual EGFR and CSK inhibitors with anticancer activity in a murine model of hepatocellular carcinoma.

Caffeic acid phenethyl ester (CAPE), a bioactive component extracted from propolis of honeybee hives, can inhibit hepatocellular carcinoma (HCC). In order to explore more stable CAPE derivatives, 25 compounds were designed, synthesized, and pharmacologically assessed in vitro and in vivo as anti-tumor agents in HCC. Compounds 8d, 8f, 8l, 8j, and 8k showed favorable antiproliferative activity than other compounds including CAPE in the HCC cell lines.

Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.

Zinc finger protein 403 (ZFP403), located on human chromosome 17q12‑21, is closely associated with the development of cancer. However, to date, there are a limited number of studies on the biological functions of this gene, particularly in prostate cancer (PCa). The results of the present study demonstrated that compared with normal tissues, the expression of ZFP403 was markedly lower in PCa tissues, as shown by the evaluation of the Gene Expression Profiling Interactive Analysis 2 database.

Laboratory Evaluation of a Vertical Vibration Testing Method for an SMA-13 Mixture.

In order to simulate the on-site compaction conditions of a Stone Matrix Asphalt (SMA) mixture, The Vertical Vibration Testing Method (VVTM), Superpave Gyratory Compactor (SGC), and Marshall method are used to test the SMA-13 mixture, and the physical and mechanical properties of the asphalt mixture designed by these three methods are tested. Subsequently, the influences of the molding method on the mechanical properties are compared. The influence of vibration compaction time on the volume parameters of the SMA mixture is studied.

Cement-Modified Loess Base for Intercity Railways: Mechanical Strength and Influencing Factors Based on the Vertical Vibration Compaction Method.

Cement-modified loess has been used in the recent construction of an intercity high-speed railway in Xi'an, China. This paper studies the mechanical strength of cement-modified loess (CML) compacted by the vertical vibration compaction method (VVCM). First, the reliability of VVCM in compacting CML is evaluated, and then the effects of cement content, compaction coefficient, and curing time on the mechanical strength of CML are analyzed, establishing a strength prediction model.

Effects of storage on brown rice ( L.) metabolites, analyzed using gas chromatography and mass spectrometry.

Metabolomic studies were carried out using gas chromatography and mass spectrometry (GC-MS) on Daohuaxiang variety rice ( L.) from the Wuchang Geographical Indication Rice Protection Area in Heilongjiang Province, to investigate the effects of storage on brown rice metabolism. The data were subjected to principal component analysis (PCA), orthogonal partial least squares-discriminant analysis (OPLS-DA), and cluster analysis using software such as SIMCA.

Effect of storage on metabolites of brown rice.

Background: Storage is an essential part of brown rice circulation. During the storage process, the metabolic activity of brown rice is still ongoing, and long-term storage leads to the deterioration of brown rice. Metabolomics analysis was performed using gas chromatography-mass spectrometry to investigate the changes in metabolites of brown rice after storage at 18 °C for 12 months.