The regeneration and repair of natural bone is a complex and multifaceted process. Potentially, multifunctional scaffolds that exhibit synergistic effects of various biological activities and align with the dynamic bone healing process, are highly expected to achieve desirable bone repairing outcomes. Bioavailable magnesium (Mg) is an essential element taking part in bone regeneration via promoting angiogenesis and osteogenesis.
View Article and Find Full Text PDFBackground/objectives: The BZR gene family, a critical transcription factor in the brassinosteroid (BR) signaling pathway, regulates plant growth and development. Despite its significance, the BZR gene family in , a valuable forage grass renowned for its stress tolerance and nutritional quality, remains uncharacterized, and its functional roles are largely unexplored.
Methods: Employing advanced bioinformatics tools, we conducted a genome-wide survey to identify members of the BZR gene family in .
Contemporary clinical interventions for cartilage injuries focus on symptom management through pharmaceuticals and surgical procedures. Recent research has aimed at developing innovative scaffolds with biochemical elements, yet challenges like inadequate targeted delivery and reduced load-bearing capacity hinder their adoption. Inspired by the spatial gradients of biophysical and biochemical cues in native osteochondral tissues, a silk-based hydrogel that facilitates spontaneous dual-gradient formation, including mechanical gradients and growth factor gradients, for tissue regeneration, is presented.
View Article and Find Full Text PDFBacterial infections, particularly those involving biofilms, pose significant treatment challenges due to their resistance to traditional antibiotics. Herein, this research explores the integration of selenium-tellurium nanoparticles (SeTe NP) and zinc oxide (ZnO) NP to create hybrid NP with dual photodynamic and photothermal properties. The synthesized SeTe-ZnO NP demonstrated significant efficacy against both Gram-positive (), () and Gram-negative (), () bacteria, effectively disrupting biofilm formation and promoting wound healing.
View Article and Find Full Text PDFFeCoNiIrPtPd/NCNT exhibits 3.4- and 1.6-fold higher levels of mass activity than does commercial Pt/C in the hydrogen evolution reaction (HER) and ethanol oxidation reaction (EOR), respectively.
View Article and Find Full Text PDFMetastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application to tumors. To overcome these limitations, a self-sustained organelle-mimicking nanoreactor is developed here with programmable DNA switches that enables bio-chem-photocatalytic cascade-driven starvation-photodynamic synergistic therapy against tumor metastasis. Emulating the compartmentalization and positional assembly strategies found in living cells, this nano-organelle reactor allows quantitative co-compartmentalization of multiple functional modules for the designed self-illuminating chemiexcited PDT system.
View Article and Find Full Text PDFHigh-performance bifunctional electrocatalyst for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) is the keystone for the industrialization of rechargeable zinc-air battery (ZAB). In this work, the modulation in the spin state of Fe single atom on nitrogen doped carbon (Fe-NC) is devised by CoO (CoO@Fe-NC), and a mediate spin state is recorded. Besides, the d band center of Fe is downshifted associated with the increment in e filling revealing the weakened interaction with OH moiety, resulting in a boosted ORR performance.
View Article and Find Full Text PDFNucleic acid delivery in hard-to-transfect macrophages have attracted increasing attention in diverse applications such as defence against bacterial infection. Regulated by microenvironments in specific applications, macrophages have a heterogenous nature and exist in different phenotypes with diverse functions, e.g.
View Article and Find Full Text PDFInt Arch Allergy Immunol
November 2024
The majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors. To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration. Here we show the design, synthesis, and biological evaluation of the incorporation of a ruthenium (Ru) catalyst into polymeric nanoreactors for hypoxic anticancer therapy.
View Article and Find Full Text PDFChem Commun (Camb)
October 2024
The formation of a protein corona gives nanomedicines a distinct biological identity, profoundly influencing their fate in the body. Nonspecific nanoparticle-protein interactions are typically highly heterogeneous, which can lead to unique biological behaviors and fates for individual nanoparticles that remain underexplored. To address this, we have established an approach that allows quantitative examination of nanoparticle-protein adsorption at the individual nanoparticle level.
View Article and Find Full Text PDFCelastrol (CEL), an active compound isolated from the root of , exhibits broad anticancer activities. However, its poor stability, narrow therapeutic window and numerous adverse effects limit its applications in vivo. In this study, an adenosine triphosphate (ATP) activatable CEL-Fe(III) chelate was designed, synthesized, and then encapsulated with a reactive oxygen species (ROS)-responsive polymer to obtain CEL-Fe nanoparticles (CEL-Fe NPs).
View Article and Find Full Text PDFCuproptosis is a novel copper-dependent programmed cell death. The efficacy of cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a high level of glutathione (GSH) in tumor cells. Here, this work develops a self-amplified cuproptosis nanoparticles (Cel-Cu NP) using celastrol (Cel), a natural product isolated from medical plant.
View Article and Find Full Text PDF(Trin.) Tzvel., also known as the "Alkali Grass", is a major forage grass in the eastern and northeastern steppe vegetation in the Songnen Prairie.
View Article and Find Full Text PDFNanoparticle-based therapies are emerging as a pivotal frontier in biomedical research, showing their potential in combating infections and facilitating wound recovery. Herein, selenium-tellurium dopped copper oxide nanoparticles (SeTe-CuO NPs) with dual photodynamic and photothermal properties were synthesized, presenting an efficient strategy for combating bacterial infections. In vitro evaluations revealed robust antibacterial activity of SeTe-CuO NPs, achieving up to 99% eradication of bacteria and significant biofilm inhibition upon near-infrared (NIR) irradiation.
View Article and Find Full Text PDFFront Public Health
May 2024
Background: Fruits are essential for health, yet their consumption in children is inadequate, with unclear influencing factors.
Methods: A cross-sectional study was conducted among students in grades 3-12 in Beijing, China, from September 2020 to June 2021. Fruit consumption in children was surveyed using a self-administered food frequency questionnaire.
Surgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting in high recurrence rates in patients. Herein, a bioactive injectable hydrogel (BG-Mn) formed by crosslinking sodium alginate (SA) with manganese-doped bioactive glass (BG-Mn) is developed as a versatile platform for anti-tumor immunotherapy and postoperative wound healing for melanoma.
View Article and Find Full Text PDFThe in vivo fate of chemotherapeutic drugs plays a vital role in understanding the therapeutic outcome, side effects, and the mechanism. However, the lack of imaging abilities of drugs, tedious labeling processes, and premature leakage of imaging agents result in loss of fidelity between the drugs and imaging signals. Herein, an amphiphilic polymer is created by copolymerization of a near-infrared-II (NIR-II) fluorophore tracer (T) and an anticancer Pt(IV) prodrug (D) of cisplatin in a hand-holding manner into one polymer chain for the first time.
View Article and Find Full Text PDFNanomaterials have attractive physicochemical properties. A variety of nanomaterials such as inorganic, lipid, polymers, and protein nanoparticles have been widely developed for nanomedicine via chemical conjugation or physical encapsulation of bioactive molecules. Superior to traditional drugs, nanomedicines offer high biocompatibility, good water solubility, long blood circulation times, and tumor-targeting properties.
View Article and Find Full Text PDFAntibody-drug conjugates (ADCs) are a new type of targeting antibodies that conjugate with highly toxic anticancer drugs via chemical linkers to exert high specificity and efficient killing of tumor cells, thereby attracting considerable attention in precise oncology therapy. Cetuximab (Cet) is a typical antibody that offers the benefits of good targeting and safety for individuals with advanced and inoperable cutaneous squamous cell carcinoma (cSCC); however, its anti-tumor activity is limited to a single use. Cisplatin (CisPt) shows good curative effects; however, its adverse effects and non-tumor-targeting ability are major drawbacks.
View Article and Find Full Text PDFTussah silk is one of the most widely used wild silks. It is usually dyed with acid dyes, despite the shortcoming of poor wet fastness. Reactive dyeing is a good solution to this problem.
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