Dynamic PAH-Related Changes: A Dataset of tRNA-Derived Small RNA Transcriptome Across Multiple Organs.

Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by elevated pulmonary artery pressure and cardiac dysfunction, often leading to heart failure and even death. Despite the complexity of its mechanisms, the molecular basis of PAH remains unclear. tRNA-derived small RNAs (tsRNAs) are noncoding RNAs that play regulatory roles in various diseases.

Serum uric acid and pulmonary arterial hypertension: A two-sample Mendelian randomization study.

Background: Observational studies have suggested a correlation between hyperuricemia and pulmonary arterial hypertension (PAH), yet the causal relationship remains uncertain. We aimed to establish this link using Mendelian Randomization (MR) methods.

Objectives: Based on publicly accessible data, our study employs MR to determine the causal relationship between uric acid (UA) and PAH.

Impact of Epicardial Adipose Tissue on Right Cardiac Function and Prognosis in Pulmonary Arterial Hypertension.

Background: Although epicardial adipose tissue (EAT) is linked to effects on survival in left-sided heart failure, the association between EAT and right-sided heart failure caused by pulmonary arterial hypertension (PAH) remains unknown.

Research Question: What are the potential impacts of EAT volume (EATV) on right ventricular function, biomarkers of myocardial injury, and long-term prognosis in patients with PAH?

Study Design And Methods: A total of 135 age- and BMI-matched patients with PAH and 49 control participants were included in this study. EATV was quantified by using cardiac magnetic resonance and was related to clinical correlates, N-terminal pro-brain natriuretic peptide, and cardiac function.

Evaluating the role of serum uric acid in the risk stratification and therapeutic response of patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD).

Pulmonary arterial hypertension (PAH) is a malignant pulmonary vascular disease that negatively impacts quality of life, exercise capacity, and mortality. This study sought to investigate the relationship between serum uric acid (UA) level and the disease severity and treatment response of patients with PAH and congenital heart disease (PAH-CHD). This study included 225 CHD patients and 40 healthy subjects.

Effect of remimazolam tosilate on early cognitive function in elderly patients undergoing upper gastrointestinal endoscopy.

Background And Aim: Remimazolam tosilate (RT) is under evaluation as a sedative for endoscopic procedures. Herein, we aimed to evaluate safety including cognition recovery of RT administered in elderly patients undergoing upper gastrointestinal endoscopy and assess its safety dosage.

Methods: Ninety-nine patients presenting for upper gastrointestinal endoscopy were randomized to receive 0.

[Correlation between kynurenine metabolites and postpartum depression].

To explore the correlation between kynurenine (KYN) metabolites and postpartum depression (PPD), and to provide new possible explanation for the pathogenesis of postpartum depression (PPD).
 Methods: A total of 726 Chinese women, who received cesarean section, were enrolled in this study. PPD was diagnosed with an Edinburgh Postnatal Depression Scale (EPDS) score ≥13.

Entropy SVM-Based Recognition of Transient Surges in HVDC Transmissions.

Protection based on transient information is the primary protection of high voltage direct current (HVDC) transmission systems. As a major part of protection function, accurate identification of transient surges is quite crucial to ensure the performance and accuracy of protection algorithms. Recognition of transient surges in an HVDC system faces two challenges: signal distortion and small number of samples.

Analysis of sport-injured pattern of anterior cruciate ligament in the reconstruction period of Chinese college students.

Background: In this study, we aimed to investigate the college students' injury patterns caused by sport activities in anterior cruciate ligament (ACL) reconstruction stage, and to estimate the association between activities at the time of injury and the odds of simplex ACL injuries.

Methods: A cohort of 2548 college students with primary ACL reconstruction was recruited from Hebei Province, China. Football, basketball, sprint, table tennis and badminton had been chosen as the most prevalent sports activities causing injuries in colleges.