Novel injectable self-healing bifunctionalized chitosan hydrogel with cell proliferation and antibacterial activity for promoting wound healing.

Wound healing is a complex and continuous process and there is an urgent need to develop effective, functional wound dressings to accelerate wound healing. In this study, we developed an injectable self-healing dual-modified chitosan composite hydrogel, referred to as CSTA@Gel. This hydrogel exhibits good properties, including effective tissue adhesion, rapid hemostatic ability, and good cytocompatibility and hemocompatibility.

Efficient Capture of ReO from Water by Imidazolium-Based Cationic Polymeric Nanotraps.

Rhenium represents an irreplaceable metal resource, which finds extensive applications in diverse fields, particularly in the aerospace and petrochemical industry. However, its remarkably low natural abundance and the lack of independent ore deposits pose significant challenges to its extraction and recovery processes. In this study, we present the highly efficient adsorption of perrhenate by a cationic polymeric nanotrap material, namely CPN-3VIm.

Resonant Quantum Magnetodielectric Effect in Multiferroic Metal-Organic Framework [CHNH]Co(HCOO).

The observation of both resonant quantum tunneling of magnetization (RQTM) and resonant quantum magnetodielectric (RQMD) effect in the perovskite multiferroic metal-organic framework [CHNH]Co(HCOO).is reported. An intrinsic magnetic phase separation emerges at low temperatures due to the hydrogen-bond-modified long-range super-exchange interaction, leading to the coexistence of canted antiferromagnetic order and single-ion (Co) magnets.

Perfluorohexanesulfonic Acid (PFHxS) Induces Hepatotoxicity through the PPAR Signaling Pathway in Larval Zebrafish ().

In recent years, the industrial substitution of long-chain per- and polyfluoroalkyl substances (PFAS) with short-chain alternatives has become increasingly prevalent, resulting in the widespread environmental detection of perfluorohexanesulfonic acid (PFHxS), a short-chain PFAS. However, there remains limited information about the potential adverse effects of PFHxS at environmental concentrations to wildlife. Here, early life stage zebrafish () were exposed to environmentally relevant concentrations of PFHxS to better characterize the adverse effects of PFHxS on aquatic organisms.

Silver functionalized chitosan composite hydrogel with sustained silver release and enhanced antibacterial properties promotes healing of infected wounds.

Bacterial infections during wound healing often cause inflammation, which delays the healing process. Therefore, innovative wound dressings are urgently needed to inhibit bacterial infections and promote healing. This study proposes an Ag-functionalized chitosan hydrogel dressing, formed via a Schiff-base reaction between alkynyl Ag substituted chitosan (Ag-CS) and octafunctionalized polyhedral oligomeric silsesquioxane with benzaldehyde-terminated polyethylene glycol (POSS-PEG-CHO), to address the issue of bacterial infection in wounds.

Image Copy-Move Forgery Detection via Deep PatchMatch and Pairwise Ranking Learning.

Recent advances in deep learning algorithms have shown impressive progress in image copy-move forgery detection (CMFD). However, these algorithms lack generalizability in practical scenarios where the copied regions are not present in the training images, or the cloned regions are part of the background. Additionally, these algorithms utilize convolution operations to distinguish source and target regions, leading to unsatisfactory results when the target regions blend well with the background.

A novel gene signature based on endoplasmic reticulum stress for predicting prognosis in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) remains one of the most common human cancers, the death cases induced by HCC are increasing these years. Endoplasmic reticulum stress (ERS) occurs when misfolded proteins cannot be disposed of properly. It is reported that ERS plays a crucial role in the pathogenesis of human malignant tumors.

Perfluorohexanesulfonic Acid (PFHxS) Impairs Lipid Homeostasis in Zebrafish Larvae through Activation of PPARα.

Perfluorohexanesulfonic acid (PFHxS), an emerging short-chain per- and polyfluoroalkyl substance, has been frequently detected in aquatic environments. Adverse outcome pathway studies have shown that perfluorinated compounds impair lipid homeostasis through peroxisome proliferator activated receptors (PPARs). However, many of these studies were performed at high concentrations and may thus be a result of overt toxicity.

Polo-like kinase 4 promotes tumorigenesis and glucose metabolism in glioma by activating AKT1 signaling.

Glioblastoma (GBM) is an extremely aggressive tumor associated with a poor prognosis that impacts the central nervous system. Increasing evidence suggests an inherent association between glucose metabolism dysregulation and the aggression of GBM. Polo-like kinase 4 (PLK4), a highly conserved serine/threonine protein kinase, was found to relate to glioma progression and unfavorable prognosis.

Studies on adsorption properties of magnetic composite prepared by one-pot method for Cd(II), Pb(II), Hg(II), and As(III): Mechanism and practical application in food.

A one-pot synthesis afforded a magnetic, crosslinked polymer adsorbent (m-P6) with a variety of functional groups to realize simultaneous adsorption of Cd, Pb, Hg, and As. The material was characterized by TEM-EDS, XRD, FT-IR, VSM, and XPS. Kinetic and isothermal analyses suggested mainly chemisorption processes of heavy metal ions that form multiple layers on heterogeneous surfaces.

Long non‑coding RNAs in gallbladder cancer: From mechanisms to therapeutic opportunities (Review).

Due to the lack of specific symptoms, characteristic diagnostic markers and effective comprehensive treatment, gallbladder cancer (GBC) is currently considered one of the most malignant abdominal tumors. With the rapid development of biological technologies, long non‑coding RNAs (lncRNAs), once regarded as transcriptional junk, have been demonstrated to participate in almost the whole process of the central dogma of molecular biology. The central dogma deals with the transfer of sequential information at the level of individual residues.

Flow-driven translocation of comb-like copolymer micelles through a nanochannel.

Using hybrid lattice-Boltzmann molecular dynamics simulations, we investigate the flow-driven translocation of comb-like copolymer micelles through a nanochannel, in particular, making a detailed comparison with micelles formed by the corresponding diblock copolymers. Our results demonstrate that the critical flow flux of micelles formed by the comb-like copolymers is higher than that of micelles formed by the corresponding diblock copolymers, which is more pronounced with increasing side chain lengths or grafting densities, as evidenced by the free energy computed by self-consistent field theory. Our work indicates that the impact of chain topology on the stability of micelles, especially with the same size, can be well characterized using the critical flow fluxes, which provides a theoretical basis for designing self-assembling micelles for various applications.

Undescribed indole lactones from Alstonia scholaris protecting hepatic cell damage.

Six previously undescribed rigidly monoterpenoid indole alkaloids, alstolactines F-K (1-6), were isolated from Alstonia scholaris. Among them, a pair of cage-like epimers, 1 and 2, featuring a rare 6/5/6/6/7 ring system, represent the first example of C→C-olide, while compound 3 possesses unique degraded C and C. The structures of the isolates were established by multiple spectroscopic analyses, quantum computational chemistry methods, and X-ray diffraction.

Biomimetic hybrid nanovesicles improve infected diabetic wound via enhanced targeted delivery.

Infected diabetic wounds have been raising the global medical burden because of its high occurrence and resulting risk of amputation. Impaired endothelium has been well-documented as one of the most critical reasons for unhealed wounds. Recently, endothelial cell-derived nanovesicles (NVs) were reported to facilitate angiogenesis, whereas their efficacy is limited in infected diabetic wounds because of the complex niche.

Bimetallic UiO-66-NH(Zr-Hf) synergistic photocatalytic and piezoelectric effects for the degradation of rhodamine B.

A series of bimetallic UiO-66-NH(Zr-Hf) metal-organic frameworks (MOFs) were prepared by a green hydrothermal method and tested for their photocatalytic and piezo-catalytic properties. Among them, UN(0.75Zr) (metal node: 0.

Phytochemical Analysis and Anti- Activity of Different Species and .

plants (ZPs), including multiple Chinese prickly ash species, are dual-purpose functional foods favored by the general population around the world in foods, cosmetics, and traditional medicines and have antipruritic, insecticidal, and fungicidal bioactivities. For the first time, the anti-roundworm bioactivity of ZPs and the active ingredients were compared and investigated. Through nontarget metabolomics following targeted quantitative analysis, qinbunamides, sanshools, sanshooel, asarinin, and sesamin were found to be the main different components of species.

Steroidal alkaloids from the roots of Veratrum stenophyllum.

Three new steroidal alkaloids, veratrasines A - C (1-3), along with ten known analogues (4-13) were isolated from the roots of Veratrum stenophyllum. Their structures were elucidated by NMR and HRESIMS data and comparison with the reported data in the literatures. A plausible biosynthetic pathway for 1 and 2 were proposed.

LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway.

Our previous studies showed that dysregulation of the long noncoding RNA (lncRNA) HOXA11-AS plays an important role in the development of glioma. However, the molecular mechanism of HOXA11-AS in glioma remains largely unknown. In this study, we explore the molecular mechanisms underlying abnormal expression and biological function of HOXA11-AS for identifying novel therapeutic targets in glioma.

Novel insight into the functions of N‑methyladenosine modified lncRNAs in cancers (Review).

Emerging evidence has suggested that N‑methyladenosine (m6A) modification, a typical RNA methylation modification, controls the fate of modified transcripts and is involved in the pathogenesis of various human diseases, such as metabolic disorders, nephropathology, osteoarthritis and malignant tumours. Long noncoding RNAs (lncRNAs), transcripts of >200 nt in length, have also been indicated to be involved in various diseases by participating in processes such as epigenetic modifications, transcriptional alternations and posttranslational regulation. Recent studies revealed that lncRNAs were widely modified by m6A, which has a critical role in various cellular processes that are associated with numerous disorders, particularly human cancers.

Facet-Controlled LiMnO/C as Deionization Electrode with Enhanced Stability and High Desalination Performance.

Highlights: First report of a lithium-ion battery cathode as a deionization electrode for desalination. A novel approach to suppress manganese dissolution by exposing the (111) facet is proposed. Excellent desalination performance by the LiMnO/C cathode.

Use of folic acid supplementation to halt and even reverse the progression of gastric precancerous conditions: a meta-analysis.

Background: Current data indicate that supplements such as folic acid and vitamin B may be beneficial in halting and even reversing atrophic gastritis, intestinal metaplasia and intraepithelial neoplasia, generally referred to as gastric precancerous conditions(GPC). However, there is no Meta-analysis article to evaluate the prevention and treatment of folic acid in the gastric precancerous conditions. We therefore conducted a meta-analysis to confirm the efficacy of folic acid in treating GPC.