Polysaccharides isolated from Cibotium barometz attenuate chronic inflammatory pain: Molecular chemical structure and role of phenylalanine.

This investigation represents a pioneering effort to examine the therapeutic effects of PCB specifically in the context of CFA-induced mice, as well as to elucidate the underlying mechanisms that facilitate such effects. Our study utilized advanced methodologies, namely high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS)-based metabolomics, alongside comprehensive multivariate data analysis, to identify a distinctive metabolic profile associated with acute inflammation. Through our analyses, we discovered that several potential metabolites were significantly implicated in a variety of critical metabolic pathways.

sp. nov. and sp. nov., Isolated from the Discovery Deep Brine-Seawater Interface in the Red Sea.

Two extremely halophilic archaeal strains, designated SB29 and SB3, were isolated from the brine-seawater interface of Discovery Deep in the Red Sea. Cells of both strains were pleomorphic (irregular polyhedrals, ovals, and rods) and stained Gram-negative; colonies were pigmented pink. The sequence similarity of the 16S rRNA gene of strain SB29 with that of its most closely related validly described species ( DSM 16227) and that of strain SB3 with its closest validly described relative ( ATCC 35960) was 98.

Chondroitin sulfate from sturgeon bone protects rat chondrocytes from hydrogen peroxide-induced damage by maintaining cellular homeostasis through enhanced autophagy.

We previously reported that treatment with chondroitin sulfate from sturgeon bone (CSSB) promoted anti-apoptotic activity in hydrogen peroxide (HO)-treated chondrocytes and had a protective effect on mitochondria. It is known that cells can repair damaged mitochondria through autophagy, thus inhibiting the development of apoptosis. Therefore, it is reasonable to speculate that CSSB treatment may inhibit chondrocyte apoptosis via regulation of autophagy.

Aliifodinibius salipaludis sp. nov., Isolated from Saline-Alkaline Soil.

A Gram-staining-negative, oblong or rod-shaped, non-flagellated and facultatively anaerobic bacterium, designated WN023, was isolated from natural saline-alkali wetland soil of Binhai new district, Tianjin, China. The colonies of strain WN023 on marine agar 2216 (MA) have a brown, circular, wet pigmentation, and its cells are approximately 1-1.5 μm × 2.

Comparative genomic and functional analysis of Akkermansia muciniphila and closely related species.

Background: Akkermansia muciniphila is an important bacterium that resides on the mucus layer of the intestinal tract. Akkermansia muciniphila has a high abundance in human feces and plays an important role in human health.

Objective: In this article, 23 whole genome sequences of the Akkermansia genus were comparatively studied.

Chondroitin sulfate from sturgeon bone protects chondrocytes via inhibiting apoptosis in osteoarthritis.

We have previously reported that chondroitin sulfate extracted from Sturgeon bone (CSSB) can alleviate the pain caused by osteoarthritis (OA) by reducing the expression of matrix metalloproteinases (MMPs) and inflammatory factors (IL-1, TNF-α and PGE). However, the mechanism of CSSB for treating OA remains unclear. As is generally accepted, these proteins and factors are regulated by chondrocyte apoptosis in OA.

Complete Genome Sequencing of WRN014, and Comparison with Genome Sequences of other Strains.

strain WRN014 was isolated from banana fields in Hainan, China. is an important member of the plant growth-promoting rhizobacteria (PGPR) which can enhance plant growth and control soil-borne disease. The complete genome of WRN014 was sequenced by combining Illumina Hiseq 2500 system and Pacific Biosciences SMRT high-throughput sequencing technologies.

Chondroitin sulfate from sturgeon bone ameliorates pain of osteoarthritis induced by monosodium iodoacetate in rats.

Chondroitin sulfate (CS) is an important component of the extracellular matrix of cartilage and has been widely used as one of the main drugs for the treatment of joint pain-related nutraceuticals and medicines. Sturgeon bone (SB) is the main waste during deep processing of sturgeons in fishery production. The present study was evaluated the therapeutic effect of CS from SB (CSSB) on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) pain and further explored the potential medicinal value of CSSB.

Association of serum Ninjurin2 levels with neurologic damage and postherpetic neuralgia occurrence: an observational cohort study in chinese herpeszoster patients.

Objectives: Postherpetic neuralgia(PHN) is the most common complication of herpeszoster (HZ) infection. The study aimed to explore whether serum Ninjurin2 (for nerve injury-induced protein 2, NINJ2), a novel neurologic damage related protein, is associated with nerve injury and the occurrence of PHN.

Results: Seventy-four of the eighty patients completed the study.

Comparison of the efficacy and safety between dezocine injection and morphine injection for persistence of pain in Chinese cancer patients: a meta-analysis.

The association between the efficacy and safety of dezocine injection and morphine injection for persistence of pain in patients with cancer had yielded controversial results. Therefore, we conduct a meta-analysis of existing observational published studies to assess the relationship between them among Chinese. We conducted a comprehensive research from the databases of PubMed, Web of Science, and Wan Fang Med Online for the related studies up to October 2016.

bZIP transcription factor CgAP1 is essential for oxidative stress tolerance and full virulence of the poplar anthracnose fungus Colletotrichum gloeosporioides.

Yeast AP1 transcription factor is a regulator of oxidative stress response. Here, we report the identification and characterization of CgAP1, an ortholog of YAP1 in poplar anthracnose fungus Colletotrichum gloeosporioides. The expression of CgAP1 was highly induced by reactive oxygen species.

Pregabalin in the treatment of herpetic neuralgia: results of a multicenter Chinese study.

Objective: The aim of this study was to evaluate the efficacy, impact on quality of life, and safety of pregabalin for the treatment of acute herpetic neuralgia (AHN) and subacute herpetic neuralgia (SHN).

Design: Multicenter, parallel-group, single-blind, 4-week, randomized clinical trial.

Setting: Conducted in the department of pain clinic of participating hospitals.

Genome-wide identification, phylogeny and expression profile of vesicle fusion components in Verticillium dahliae.

Vesicular trafficking plays a crucial role in protein localization and movement, signal transduction, and multiple developmental processes in eukaryotic cells. Vesicle fusion is the final and key step in vesicle-mediated trafficking and mainly relies on SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors), the regulators including SM (Sec1/Munc18) family proteins, Rab GTPases and exocyst subunits. Verticillium dahliae is a widespread soil fungus that causes disruptive vascular diseases on a wide range of plants.