Deciphering the impact of urban built environment density on respiratory health using a quasi-cohort analysis of 5495 non-smoking lung cancer cases.

Introduction: Lung cancer is a major health concern and is influenced by air pollution, which can be affected by the density of urban built environment. The spatiotemporal impact of urban density on lung cancer incidence remains unclear, especially at the sub-city level. We aimed to determine cumulative effect of community-level density attributes of the built environment on lung cancer incidence in high-density urban areas.

Erratum: Corrigendum: The distribution and behavioral characteristics of plateau pikas (). ZooKeys 1059: 157-171. https://doi.org/10.3897/zookeys.1059.63581.

[This corrects the article DOI: 10.3897/zookeys.1059.

Neoadjuvant chemotherapy with liposomal paclitaxel plus platinum for locally advanced esophageal squamous cell cancer: Results from a retrospective study.

Background: This study analyzed the efficacy and safety of neoadjuvant chemotherapy with liposomal paclitaxel plus platinum in patients with locally advanced resectable esophageal squamous cell carcinoma (ESCC).

Methods: The data of patients with locally advanced resectable ESCC (staging cT2N + M0, cT3-4aNanyM0, IA-IVA) who received preoperative chemotherapy with liposomal paclitaxel plus platinum (cisplatin, nedaplatin or carboplatin) in HuanXing Cancer Hospital from July 2018 to October 2019 were collected. The primary endpoint of this study was R0 resection rate, and secondary endpoints were pathological complete response (pCR) rate, 1- and 2-year overall survival (OS) rate, 1-year and 18-month disease-free survival (DFS) rate, and safety.

The distribution and behavioral characteristics of plateau pikas ().

Plateau pikas () are regarded as one of the main causes of the degradation of alpine meadows in the Qinghai-Tibet Plateau (QTP). The population density of plateau pikas is directly related to the degree of grassland damage. In this study, field observation was conducted for one week in the southeastern QTP in August 2019.

A density estimation model of plateau pika () supporting camera-monitoring programs.

As an important species in the Qinghai-Tibet Plateau, the roles played by plateau pikas in grassland degradation and protection are controversial. The behavior characteristics and population density of this species are important in answering this question, but these traits have not been fully elucidated to date. Camera-capture methods have been used widely in recent years to characterize or calculate population density with the advantage of simple operation and nonintrusive investigation.

A Novel Crow Swarm Optimization Algorithm (CSO) Coupling Particle Swarm Optimization (PSO) and Crow Search Algorithm (CSA).

The balance between exploitation and exploration essentially determines the performance of a population-based optimization algorithm, which is also a big challenge in algorithm design. Particle swarm optimization (PSO) has strong ability in exploitation, but is relatively weak in exploration, while crow search algorithm (CSA) is characterized by simplicity and more randomness. This study proposes a new crow swarm optimization algorithm coupling PSO and CSA, which provides the individuals the possibility of exploring the unknown regions under the guidance of another random individual.

A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator.

Lysophosphatidic acid receptor 6 (LPAR6) is a G protein-coupled receptor that plays critical roles in cellular morphology and hair growth. Although LPAR6 overexpression is also critical for cancer cell proliferation, its role in liver cancer tumorigenesis and the underlying mechanism are poorly understood. Here, using liver cancer and matched paracancerous tissues, as well as functional assays including cell proliferation, quantitative real-time PCR, RNA-Seq, and ChIP assays, we report that LPAR6 expression is controlled by a mechanism whereby hepatocyte growth factor (HGF) suppresses liver cancer growth.