Urolithin A attenuates Doxorubicin-induced cardiotoxicity by enhancing PINK1-regulated mitophagy via Ambra1.

Doxorubicin (Dox) is a widely used antineoplastics although its clinical usage is greatly limited by its cardiotoxicity. Several studies have depicted an essential role for dampened mitophagy and mitochondrial injury in Dox cardiotoxicity. However, preventative measure to alleviate Dox-evoked cardiotoxicity via targeting mitophagy and mitochondrial integrity remains elusive.

NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy.

Endoplasmic reticulum stress-induced cell apoptosis is a pivotal mechanism underlying the progression of cardiac hypertrophy. NLRX1, a member of the NOD-like receptor family, modulates various cellular processes, including STING, NF-κB, MAPK pathways, reactive oxygen species production, essential metabolic pathways, autophagy and cell death. Emerging evidence suggests that NLRX1 may offer protection against diverse cardiac diseases.

Prognostic Model of D2 Radical Gastrectomy Combined with Neoadjuvant Chemotherapy for Gastric Cancer.

Purpose: The AJCC (the American Joint Committee on Cancer) ypTNM (post-neoadjuvant pathologic stage group) staging was established based on patients with lymphadenectomy scope less than D2 and did not include ypT0N0 patients with pathologically complete response (PCR). The purpose of this study was to construct a survival predictive model for gastric cancer patients after neoadjuvant chemotherapy and gastrectomy combined with D2 lymphadenectomy.

Patients And Methods: The multicenter data of 838 gastric cancer patients who received neoadjuvant chemotherapy and gastrectomy combined with D2 lymphadenectomy were analyzed retrospectively.

Hollow Structured Micro/Nano MoS₂ Spheres for High Electrocatalytic Activity Hydrogen Evolution Reaction.

Molybdenum disulfide (MoS2) has attracted extensive attention as a non-noble metal electrocatalyst for hydrogen evolution reaction (HER). Controlling the skeleton structure at the nanoscale is paramount to increase the number of active sites at the surface. However, hydrothermal synthesis favors the presence of the basal plane, limiting the efficiency of catalytic reaction.

Preparation of hollow microsphere@onion-like solid nanosphere MoS2 coated by a carbon shell as a stable anode for optimized lithium storage.

A one-step hydrothermal method was successfully used to fabricate hollow microsphere@onion-like solid nanosphere MoS2. Then the as-prepared sS-MoS2 was decorated with a carbon shell using dopamine as a carbon source by a facile route, resulting in hollow microsphere@onion-like solid nanosphere MoS2 decorated with carbon shell (sS-MoS2@C). A synergistic effect was observed for the two-component material, leading to new electrochemical processes for lithium storage, with improved electroconductivity and structural soundness, triggering an ascending capacity upon cycling.

Enhanced field emission and photocatalytic performance of MoS₂ titania nanoheterojunctions via two synthetic approaches.

Two types of molybdenum disulfide (MoS2) titania nanoheterojunctions with different morphologies were synthesized via two different approaches. They were facile and additive-free hydrothermal processes, which resulted in a high material productivity and controllable morphologies. Both the synthesis and their growth mechanisms are discussed in this paper.

Facile synthesis of novel MoS₂@SnO₂ hetero-nanoflowers and enhanced photocatalysis and field-emission properties.

A novel hierarchical MoS2@SnO2 hetero-nanoflower was successfully synthesized by a facile, two-step hydrothermal method without using any additives or surfactants. One possible growth mechanism of the hetero-nanostructure was presented in detail based on OH(-) ion-dependent experimental facts. Due to the formation of the p-n junctions and the increased specific surface area in the composites, an outstanding photocatalytic activity of the as-prepared sample was obtained by monitoring the photodegradation of methylene blue (MB).

[Clinical application of M-CHAT and CHAT-23 for autism screening].

Objective: To analyze and compare Modified Checklist for Autism in Toddlers (M-CHAT) and Checklist for Autism in Toddlers-23 (CHAT-23) in terms of clinical applicability, and to provide a basis for the understanding of early specific clinical manifestations of children with autism.

Methods: A total of 350 children aged 18-36 months who visited the Department of Developmental Pediatrics of Shengjing Hospital of China Medical University were enrolled as subjects. Of the 350 children, 284 who had not been previously diagnosed with autism were screened according to the two checklists.

[Relationship between gene mutations and intelligence in children with Duchenne muscular dystrophy].

Objective: To study the level of intelligence in children with Duchenne muscular dystrophy (DMD), and the relationship between the level of intelligence and gene mutations.

Methods: One hundred and two children with DMD between January 2009 and March 2011 were enrolled. DMD gene detection was performed through the multiplex ligation-dependent probe amplification (MLPA) in 84 cases.

Analysis of MECP2 gene copy number in boys with autism.

Autism is a severe neurodevelopmental disorder with a strong genetic basis.The methyl-CpG binding protein 2 gene (MECP2) is a dosage-sensitive gene in brain development and has been implicated as a candidate gene for autism. Duplication of the MECP2 gene has been reported in a few boys with autistic features.