Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics.

Background And Objectives: Real-time blood flow variation is crucial for understanding the dynamic development of coronary atherosclerosis. The main objective of this study is to investigate the effect of varying extent of stenosis on the hemodynamic features in left anterior descending coronary artery.

Methods: Various Computational fluid dynamics (CFD) models were constructed with patient-specific CT image data, using actual fractional flow reserve (FFR) as boundary conditions to provide a real-time quantitative description of hemodynamic properties.

Medical image fusion quality assessment based on conditional generative adversarial network.

Multimodal medical image fusion (MMIF) has been proven to effectively improve the efficiency of disease diagnosis and treatment. However, few works have explored dedicated evaluation methods for MMIF. This paper proposes a novel quality assessment method for MMIF based on the conditional generative adversarial networks.

Connected neurons in multiple neocortical areas, comprising parallel circuits, encode essential information for visual shape learning.

Neocortical areas comprised of multiple neuronal circuits which are encoded with innumerable advanced cognitive tasks. Studies focused on neuronal network and synaptic plasticity has hypothesized that every specific neuron and the circuit process the explicit essential information for the specific tasks. However, the structure of these circuits and the involved critical neurons remain to be elucidated.

Computational fluid dynamics simulation of time-resolved blood flow in Budd-Chiari syndrome with inferior vena cava stenosis and its implication for postoperative efficacy assessment.

Background: This study aimed to adopt computational fluid dynamics to simulate the blood flow dynamics in inferior vena cava stenosis based on time-dependent patient-specific models of Budd-Chiari syndrome as well as a normal model. It could offer valuable references for a retrospective insight into the underlying mechanisms of Budd-Chiari syndrome pathogenesis as well as more accurate evaluation of postoperative efficacy.

Methods: Three-dimensional inferior vena cava models of Budd-Chiari syndrome patient-specific (preoperative and postoperative) and normal morphology model were reconstructed as per magnetic resonance images using Simpleware.

Fractional flow reserve-based 4D hemodynamic simulation of time-resolved blood flow in left anterior descending coronary artery.

Background: The purpose of this study was to investigate the feasibility of the non-invasive assessment of hemodynamic parameters with computational fluid dynamics in left anterior descending coronary artery based on invasive fractional flow reserve.

Methods: A left coronary artery model based on computed tomography angiography was reconstructed using MIMICS 18.0 for computational fluid dynamics analysis.

Ethanol's Effect on Expression in the Hippocampus of Mice.

Coenzyme Q (CoQ) is a well-studied molecule, present in every cell membrane in the body, best known for its roles as a mitochondrial electron transporter and a potent membrane anti-oxidant. Much of the previous work was done in yeast and more recent work has suggested that CoQ may have additional roles prompting calls for a re-assessment of its role using systems in mammals. Here we investigated the putative role of Coenzyme Q in ethanol-induced effects using BXD RI mice.

Numerical simulation of hemodynamics in membranous obstruction of the suprahepatic inferior vena cava based on a subject-specific Budd-Chiari syndrome model.

Background: This study was performed to determine the hemodynamic changes of Budd-Chiari syndrome when the inferior vena vein membrane is developing.

Methods: A patient-specific Budd-Chiari syndrome vascular model was reconstructed based on magnetic resonance images using Mimics software and different degrees (16%, 37%, and 54%) of idealized membrane were built based on the Budd-Chiari syndrome vascular model using Geomagic software. Three membrane obstruction Budd-Chiari syndrome vascular models were established successfully and fluent software was used to simulate hemodynamic parameters, including blood velocity and wall shear stress.

The effect of alcohol on the differential expression of cluster of differentiation 14 gene, associated pathways, and genetic network.

Alcohol consumption affects human health in part by compromising the immune system. In this study, we examined the expression of the Cd14 (cluster of differentiation 14) gene, which is involved in the immune system through a proinflammatory cascade. Expression was evaluated in BXD mice treated with saline or acute 1.

[Application of FTIR and Active Ingredients Quantitative Analysis on Quality Control of Dai Medicine Alstonia scholaris (L.) R. Br.].

FTIR fingerprint of the leaves and immature stems of Alstonia scholaris (L.) R. Br.

[Distinguish and Quality Estimation of the Leaves of Alstonia scholaris (L.) R. Br. from Different Harvest Time Based on the UV-Vis·FP and HPLC·FP].

UV-Vis and HPLC fingerprint of different harvest time of the leaves of Alstonia scholaris (L.) R. Br.

Computational and experimental investigation into mechanical performances of Poly-L-Lactide Acid (PLLA) coronary stents.

Poly-L-lactide Acid (PLLA), as a credible biodegradable polymer-based material, can provide a promising amount of degradation time for vessel remodeling. Served as a sort of reliable intravascular implants, PLLA stents are expected to provide sufficient scaffolding to the target arteries without generating too much recoil after deployment. Besides, the stress and strain distribution should be as homogeneous as possible, and the stent conformability in fitting to the nature curvature of the vessels needs to be guaranteed.

Genetic expression analysis of E2F-associated phosphoprotein in stress responses in the mouse.

Dysfunction of the monoaminergic system is critical in stress and anxiety disorders, but the role of each family member in the development of stress-related psychopathologies is not sufficiently understood. Eapp has been reported to be a transcriptional repressor of monoamine oxidase B (Maob) and down-regulates Maob via the Maob core promoter. In the present study, we more specifically examine the role of Eapp in stress responses by testing the hypothesis that Eapp may be involved in the occurrence and development of stress responses.

A novel heat shock protein alpha 8 (Hspa8) molecular network mediating responses to stress- and ethanol-related behaviors.

Genetic differences mediate individual differences in susceptibility and responses to stress and ethanol, although, the specific molecular pathways that control these responses are not fully understood. Heat shock protein alpha 8 (Hspa8) is a molecular chaperone and member of the heat shock protein family that plays an integral role in the stress response and that has been implicated as an ethanol-responsive gene. Therefore, we assessed its role in mediating responses to stress and ethanol across varying genetic backgrounds.

[Study on acute toxicity and animal gastrointestinal activity of crude and processed products of Entada phaseoloides].

Objective: To study the acute toxicity of the crude and processed products of Entada phaseoloides and their effects on gastrointestinal movement in mice.

Methods: Using the method of intragastric administration, to observe the acute toxicity of the crude and processed products of Entada phaseoloides in mice and determine their LD50. With the methods of charcoal propulsion of small intestine and methyl orange colorimetry of gastric emptying, to study the impact of the crude and processed products of Entada on gastrointestinal movement in mice.

[Study on HPLC fingerprint of crude and processed products of Entada phaseoloides].

Objective: A novel method was established and the results were compared for HPLC fingerprint determination of crude and processed products of Entada phaseoloides.

Method: HPLC-UV was proposed for studying the fingerprints of fresh E. phaseoloides and their processed products, respectively.

Sulfur-containing amides from Entada phaseoloides.

To study the chemical constituents of the Entada phaseoloides (L.) Merr., seeds of Entada phaseoloides were extracted with 70% ethanol at room temperature.

[Numerical and experimental study of radial support capacity of intravascular stent].

The radial support capacity of intravascular stent is usually evaluated by the planar compression or the radial compression methods. Based on FEM simulation, the planer and radial compression methods are compared, and the agreement of the evaluation for the radial support capacity between these two methods is found. Moreover, the planer compression method is used to study the geometric parameters' effect on the radial support capacity by numerical simulations and experiments.

Two new triterpenoids from Lycopodium obscurum L.

Two new onoceranoid triterpenoids, (3 alpha,8 beta,14 alpha,21 beta)-26,27-dinoronocerane-3,8,14,21-tetrol (1) and 26-nor-8 beta-hydroxy-alpha-onocerin (2), were isolated from Lycopodium obscurum L. Their structures were elucidated on the basis of spectroscopic analyses.

[Study on microscopic observation and TLC identification of Dai medicine "Guomaguo" (Spondias pinnata)].

Objective: To study identification methods of Dai medicine" Guomaguo", the fruit of Spondias pinnata.

Methods: Characteristic, microscopic observation and TLC idertification were used to authenticate this crude drug.

Results: The characters of the cross section, powder and TLC of the drug were reported, and the relevant drawings of the tissue, powder and TLC of this ethnomedicine were drawn.

[Study on pharmacognostic identifcation of Cassia siamea].

Objective: To establish methods for identification of Dai medicine, the heartwoods and leaves of Cassia siamea.

Methods: Macroscopic, microscopic observation and TLC technique were used to anthenticate this crude drug, and the identification characteristics were studied.

Results: Macroscopic and microscopic identification methods and TLC characters of the ethnomedicine were re-ported, and the simple and detailed drawings of the transections of the heartwoods and leaves, as well as microscopic drawings of their powders were drawn in this paper.