A new deuterium-labeled compound [2,3,4,6,6'- H ]-D-glucose for deuterium magnetic resonance metabolic imaging.

Deuterium ( H) magnetic resonance imaging is an emerging approach for noninvasively studying glucose metabolism in vivo, which is important for understanding pathogenesis and monitoring the progression of many diseases such as tumors, diabetes, and neurodegenerative diseases. However, the synthesis of H-labeled glucose is costly because of the expensive raw substrates and the requirement for extreme reaction conditions, making the H-labeled glucose rather expensive and unaffordable for clinic use. In this study, we present a new deuterated compound, [2,3,4,6,6'- H ]-D-glucose, with an approximate 10-fold reduction in production costs.

Proton/Deuterium Magnetic Resonance Imaging of Rodents at 9.4T Using Birdcage Coils.

The purpose of the present study was to fabricate a volume coil for proton/deuterium magnetic resonance imaging (MRI) in rodents at 9.4 T. Two birdcage radiofrequency (RF) coils have been designed for proton/deuterium MRI: the rungs of two concentric birdcages were azimuthally interleaved with each other for better decoupling, and the two coils were tuned to 400.