Publications by authors named "Yinghe Ding"
Article Synopsis
- Reconstruction of the neurovascular unit is crucial for healing spinal cord injuries (SCI), but research on specific vascular changes and treatments is still lacking.
- A study shows that after SCI, significant vascular remodeling occurs, including larger blood vessels and damage to the blood-spinal cord barrier, influenced by osteopontin (OPN) that aids in early regeneration but also promotes pathological changes.
- Targeting the mechanism of OPN by inhibiting Foxo1 phosphorylation can reduce harmful vascular changes, leading to better axon regeneration and recovery of neurological functions after SCI, suggesting new drug therapy approaches.
Article Synopsis
- Spinal cord injury (SCI) causes problems with blood flow, leading to a lack of oxygen and energy in the affected area, which messes with how nerve cells work and heal.
- Researchers studied how these changes affect nerve repair and recovery after spinal cord injuries.
- They found that a protein called MCT1, which helps move energy-rich lactate between cells, is decreased after SCI, and increasing MCT1 helps recovery and nerve healing in mice.
Mitochondria are crucial in sustaining and orchestrating cellular functions. Capitalizing on this, we explored mitochondrial transplantation as an innovative therapeutic strategy for acute spinal cord injury (SCI). In our study, we developed an engineered mitochondrial compound tailored to target macrophages within the SCI region.
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- Macrophages in the spinal cord injury area contribute to chronic inflammation, hindering healing, whereas endothelial progenitor cell-produced exosomes (EPC-EXOs) can aid in revascularization and inflammation management.
- This study aimed to explore how EPC-EXOs influence macrophage polarization in the context of spinal cord injury.
- Findings revealed that EPC-EXOs reduce pro-inflammatory markers and enhance anti-inflammatory markers in macrophages, improving tissue preservation and motor function post-injury, particularly through the action of upregulated miR-222-3P.
Hemorrhage and immune cell infiltration are the main pathological features of spinal cord injury (SCI). Excessive iron deposition is caused by leaking hemosiderin which may over-activate ferroptosis pathways, resulting in lipid peroxidation and mitochondrial dysfunction in cells. Inhibiting ferroptosis after SCI has been shown to aid functional recovery.
View Article and Find Full Text PDFBackground: Tumor microenvironment (TME) is of great importance to regulate the initiation and advance of cancer. The immune infiltration patterns of TME have been considered to impact the prognosis and immunotherapy sensitivity in Head and Neck squamous cell carcinoma (HNSCC). Whereas, specific molecular targets and cell components involved in the HNSCC tumor microenvironment remain a twilight zone.
View Article and Find Full Text PDFBackground: The outbreak of COVID-19 has been defined by the World Health Organization as a pandemic, and containment depends on traditional public health measures. However, the explosive growth of the number of infected cases in a short period of time has caused tremendous pressure on medical systems. Adequate isolation facilities are essential to control outbreaks, so this study aims to quickly estimate the demand and number of isolation beds.
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- This study investigates the impact of hypoxia and immune status on the prognosis of idiopathic pulmonary fibrosis (IPF), aiming to create a predictive model for patient outcomes.
- Researchers analyzed microarray data and utilized various algorithms and statistical methods to identify significant genes and immune cell types associated with IPF prognosis.
- The developed prediction model, which includes both risk and protective factors, showed promising results in independent validations and demonstrated that specific immune cells and conditions significantly affect patient survival rates.
Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver.
Biomed Pharmacother
January 2021
Article Synopsis
- - COVID-19, caused by the SARS-CoV-2 virus, initially presented symptoms like fever and cough, but later research revealed gastrointestinal symptoms like vomiting and diarrhea becoming more common.
- - The ACE2 receptor, which the virus uses to enter cells, is highly present in the digestive system and liver, suggesting a significant connection between COVID-19 and digestive health.
- - The review emphasizes the need for further research into how COVID-19 affects the gastrointestinal tract and the potential mechanisms behind these digestive symptoms.
Programmed cell death-1 (PD-1) is a negative coreceptor mainly expressed on the surface of activated T cells. The binding of PD-1 to its ligand PD-L1 significantly induces non-reactivity of T cells to maintain the balance of autoimmunity and immune tolerance. It is reported that tumor cells highly express PD-L1 to restrict cellular immune response, which is one of the most important mechanisms for tumor to mediate immune escape.
View Article and Find Full Text PDFBackground: Kawasaki disease (KD) is an acute febrile illness of early childhood. The exact etiology of the disease remains unknown. At present, research on KD is mostly limited to susceptibility genes, infections, and immunity.
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