USP54 is a potential therapeutic target in castration-resistant prostate cancer.

Background: USP54, a ubiquitin-specific protease in the deubiquitinase (DUB) family, facilitates the malignant progression of several types of cancer. However, the role of USP54 in prostate cancer (PCa), especially castration-resistant prostate cancer (CRPC), remains unknown.

Methods: We established the CRPC LNCaP-AI cell line from the hormone-sensitive prostate cancer (HSPC) LNCaP cell line.

ANP32B inhibition suppresses the growth of prostate cancer cells by regulating c-Myc signaling.

ANP32B is a histone chaperone that interacts with various transcription factors that regulate cancer cell proliferation, immigration, and apoptosis. c-Myc, a well-known oncogenic protein, is a principal player in the initiation and progression of prostate cancer (PC). The means by which ANP32B and c-Myc act remain unknown.

A cross-sectional study of clinical emergency department nurses' occupational stress, job involvement and team resilience.

Introduction: The occupational stress of clinical nurses has drawn increasing attention. It has been proven that occupational stress is related to job involvement, and job involvement affects team resilience. However, research on the relationship between emergency nurses' occupational stress, job involvement and team resilience is lacking.

Identification of molecular subtypes and a prognostic signature based on chromatin regulators related genes in prostate cancer.

The clinical and molecular phenotypes of prostate cancer (PCa) exhibit substantial heterogeneity, ranging from indolent to metastatic disease. In this study, we aimed to identify PCa subtypes and construct a gene signature that can predict the recurrence-free survival (RFS) of PCa patients based on chromatin regulators genes (CRGs). Strikingly, we identified two heterogeneous subtypes with distinct clinical and molecular characteristics.

Chinese version of the stressor scale for emergency nurse: A methodological study design.

Aim: The aim of this study was to modify and test the psychometric properties of the Chinese version of the stressor scale for emergency nurses.

Design: The methodological design was carried out in two phases: (a) form the Chinese version by Delphi method and (b) test the psychometric properties by cross-sectional survey.

Methods: The translated scale was administered to 420 nurses in Qingdao.

DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling.

Background: DDX52 is a type of DEAD/H box RNA helicase that was identified as a novel prostate cancer (PCa) genetic locus and possible causal gene in a European large-scale transcriptome-wide association study. However, the functions of DDX52 in PCa remain undetermined. The c-Myc oncogene plays a crucial role in the development of PCa, but the factors that regulate the activity of c-Myc in PCa are still unknown.

USP16 regulates castration-resistant prostate cancer cell proliferation by deubiquitinating and stablizing c-Myc.

Background: c-Myc, a well-established oncogene, plays an important role in the initiation and progression of various cancers, including prostate cancer. However, its mechanism in cancer cell remains largely unknown and whether there exist a deubiquitinase targeting c-Myc also remains elusive.

Methods: Bioinformatic analysis and shRNA screening methods were used to identify potential deubiquitinases that correlate with c-Myc gene signature.

Impacts of Defocusing Amount and Molten Pool Boundaries on Mechanical Properties and Microstructure of Selective Laser Melted AlSi10Mg.

The influences of processing parameters such as volumetric energy density (ε) and, particularly, defocusing amount (DA) on densification, microstructure, tensile property, and hardness of the as-printed dense AlSi10Mg alloy by selective laser melting (SLM) were studied systematically. The molten pool boundaries (MPBs) were found overwhelmingly at regular and complex spatial topological structures affected by DA value to exist in two forms, while the "layer⁻layer" MPB overlay mutually and the "track⁻track" MPBs intersect to form acute angles with each other. The microstructure of MPBs exhibits a coarse grain zone near the MPBs and the characteristics of segregation of nonmetallic elements (O, Si) where the crack easily happened.