Publications by authors named "Yingguo Tian"
Non-small cell lung cancer (NSCLC) is an aggressive and rapidly expanding lung cancer. Abnormal upregulation or knockdown of PDIA6 expression can predict poor prognosis in various cancers. This study aimed to investigate the biological function of PDIA6 in NSCLC.
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- MiR-130a-3p shows anti-tumor effects across various cancers and may specifically inhibit the Wnt signaling pathway, which is crucial in tumor development.
- Both colorectal cancer (CRC) tissues and cell lines exhibited lower levels of miR-130a-3p compared to normal controls, indicating its potential role in CRC progression.
- Overexpression of miR-130a-3p reduced CRC cell growth and downregulated WNT1 and its downstream factors, with WNT1 acting as a direct target of miR-130a-3p; thus, both could be promising targets for CRC treatment.