Elevated NT-proBNP predicts unfavorable outcomes in patients with acute ischemic stroke after thrombolytic therapy.

Objective: Few studies correlated n-terminal pro-brain natriuretic peptide (NT-proBNP) with early neurological deterioration (END) and prognosis of acute ischaemic stroke (AIS) patients with rt-PA intravenous thrombolysis. Therefore this study aimed to investigate the relationship between NT-proBNP and END, and prognosis after intravenous thrombolysis in patients with AIS.

Methods: A total of 325 patients with AIS were enrolled.

1α,25-Dihydroxyvitamin D3 Promotes Angiogenesis After Cerebral Ischemia Injury in Rats by Upregulating the TGF-β/Smad2/3 Signaling Pathway.

Stroke is a disease with high morbidity, disability and mortality, which seriously endangers the life span and quality of life of people worldwide. Angiogenesis and neuroprotection are the key to the functional recovery of penumbra function after acute cerebral infarction. In this study, we used the middle cerebral artery occlusion (MCAO) model to investigate the effects of 1α,25-dihydroxyvitamin D3 (1,25-D3) on transforming growth factor-β (TGF-β)/Smad2/3 signaling pathway.

Gold Nanorods with Spatial Separation of CeO Deposition for Plasmonic-Enhanced Antioxidant Stress and Photothermal Therapy of Alzheimer's Disease.

Activities of catalase (CAT) and superoxide dismutase (SOD) of ceria nanoparticles (CeO NPs) provide the possibility for their application in nervous system oxidative stress diseases including Alzheimer's disease (AD). The addition of hot electrons produced by a plasma photothermal effect can expand the photocatalytic activity of CeO to the near-infrared region (NIR), significantly improving its redox performance. Therefore, we coated both ends of gold nanorods (Au NRs) with CeO NPs, and photocatalysis and photothermal therapy in the NIR are introduced into the treatment of AD.

High time-resolved PM composition and sources at an urban site in Yangtze River Delta, China after the implementation of the APPCAP.

In this study, hourly concentrations of PM water-soluble inorganic ions, bulk organic carbon (OC), and elemental carbon (EC) were monitored from 1/1/2017 to 12/31/2017 and validated using filter-based offline analysis at an urban site in Nanjing, China. Compared with 2013 or before, the annual average of PM concentration (36.5 ± 32.

Complex effects of apoplexy secondary to pituitary adenoma.

Pituitary adenoma apoplexy is a well-known clinical syndrome induced by insulin infusion, cardiac surgery, trauma, and hypothalamic releasing factors. Pituitary apoplexy can cause secondary cerebral infarct and internal carotid artery occlusion. With blockade of tumor perfusion, apoplexy triggers a sudden onset of headache, visual impairment, cranial nerve palsy, disturbances of consciousness, eyelid ptosis, and hemiparesis.

[Correlation Analysis Between Characteristics of VOCs and Ozone Formation Potential in Summer in Nanjing Urban District].

Volatile organic compounds (VOCs) is an important precursor of photochemical ozone pollution (O3) in the atmosphere. Their concentration variation directly affects the characteristics of the ozone pollution. The concentration, speciation of VOCs, ozone and its precursors in Nanjing were analyzed and measured using online gas detection systems in August 2013.

BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.

Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism, and loss of the stability of PINK1 may also contribute to sporadic Parkinson's disease (PD). Degradation of PINK1 occurs predominantly through the ubiquitin proteasome system (UPS), however, to date, few of the proteins have been found to regulate the degradation of PINK1. Using the yeast two-hybrid system and pull-down methods, we identified bcl-2-associated athanogene 5 (BAG5), a BAG family member, directly interacted with PINK1.

[Determination of seven nitrobenzene compounds in water samples by single-drop microextraction with capillary gas chromatography].

A method suitable for the extraction of nitrobenzene, nitrotoluenes and nitrochlorobenzenes from water samples using single-drop microextraction with capillary gas chromatography is presented. Parameters, such as organic solvents, drop volume of organics, agitation, immerge depth of needle point, aqueous sample volume, exposure time and temperature were controlled and optimized. The developed protocol was found to yield a linear calibration curve in a concentration range from 0.

[Mutation detection of parkin gene by denaturing high performance liquid chromatography].

Objective: To detect parkin gene mutation of early-onset parkinsonism (EOP) by denaturing high performance liquid chromatography (DHPLC).

Methods: The blood cell genomic DNA of 82 EOP patients was isolated. Exons of parkin gene were amplified by PCR.

[Determination of trace phenol compounds using gas chromatography-mass spectrometry coupled with Tenax adsorption tube for enrichment of air samples].

A novel determination method for trace of seven phenol compounds in air samples has been established. They were collected with Tenax adsorption tube (180 mm x 60 mm glass tube packed with 150 mg Tenax (40 - 60 mesh)) and desorbed with methanol. Five microlitres of naphthalene-D8 (internal standard) solution was added to the eluate.