Publications by authors named "Yingfei Sun"

The growing discussion on "interdisciplinary integration" brings attention to the "interprofessional education" (IPE) in the field of plastic surgery. IPE not only improves the precision and effectiveness of plastic and reconstructive surgery but also plays an important role in personalized treatment. Whereas, the implementation of IPE in plastic and reconstructive surgery field faces huge difficulties such as technology combination, standard making, and lacking of qualified talents.

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Heatstroke (HS) is gradually becoming a major challenge in the field of global public health with the trend of global warming. In recent years, extreme high-temperature weather events have occurred frequently in the world, which directly led to a significant increase in heatstroke. However, up to now, the potential pathological effects of HS on articular cartilage have not been revealed.

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The existence of noisy labels in real-world data negatively impacts the performance of deep learning models. Although much research effort has been devoted to improving the robustness towards noisy labels in classification tasks, the problem of noisy labels in deep metric learning (DML) remains under-explored. Existing noisy label learning methods designed for DML mainly discard suspicious noisy samples, resulting in a waste of the training data.

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Rank aggregation with pairwise comparisons is widely encountered in sociology, politics, economics, psychology, sports, etc. Given the enormous social impact and the consequent incentives, the potential adversary has a strong motivation to manipulate the ranking list. However, the ideal attack opportunity and the excessive adversarial capability cause the existing methods to be impractical.

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MG-HS regulates the expression of transcription factor STAT5.Transcription factor STAT5 can target miR-33-5p promoter element.MG-influenced STAT5 regulates miR-33-5p and its target gene expression.

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  • * The study highlights that low levels of let-7d microRNA in chick embryonic lungs help protect against MG by reducing the bacteria's adhesion and activating specific immune pathways.
  • * These findings suggest that downregulating let-7d can alleviate inflammation and cell death caused by MG, potentially informing future vaccine development strategies against the infection.
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  • - This study explores the impact of a major respiratory pathogen on chickens, examining how it affects embryos and newly hatched chicks, particularly through their innate immune response.
  • - The researchers found that both embryos and chicks suffered weight loss and immune damage, but embryos demonstrated a stronger immune response with more differentially expressed immune-related genes.
  • - Key immune pathways involved were identified, specifically focusing on Toll-like receptor and cytokine-mediated responses, highlighting the potential importance of TLR7 signaling in combating the infection in chickens.
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A disruption in the expression of gga-miR-365-3p was confirmed in the Mycoplasma gallisepticum (MG)-infected Chicken primary alveolar type II epithelial (CP-II) cells based on previous sequencing results, but the role it plays in the infection was unclear. In the present study, we demonstrate that MG evaded cellular host immunity via a gga-miR-365-3p/SOCS5-JAK/STATs negative feedback loop. Specifically, we found that at the initial stage of MG infection in cells, gga-miR-365-3p was rapidly increased and activated the JAK/STAT signaling pathway by inhibiting SOCS5, which induced the secretion of inflammatory factors and triggered immune response against MG infection.

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  • * Research using chicken models revealed that AG significantly reduced harmful proteins and pro-inflammatory cytokines while increasing anti-inflammatory markers, suggesting its positive impact on inflammation.
  • * AG appears to work by modulating the PI3K/Akt signaling pathway, decreasing inflammasome and apoptosis markers, and promoting autophagy, indicating it could be an effective treatment for MG infections.
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Arsenic-alkali residue (AAR) from antimony production can pose significant health and environmental hazards due to the risk of arsenic (As) leaching. In this study, geopolymer composite synthesized from fly ash (FA) was investigated for efficient stabilization of high-arsenic-containing AAR (AsO of 22.74 wt%).

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  • High-mobility group box 1 (HMGB1) is a protein that plays a role in immune responses during infections, particularly concerning Mycoplasma gallisepticum (MG) infection.
  • The study found that HMGB1 is released from macrophage nuclei during MG infection, leading to the activation of TLR2 and the NF-κB pathway, which causes severe inflammation.
  • Treatments like ethyl pyruvate and glycyrrhizic acid can inhibit HMGB1 release and may help reduce immune organ damage in MG-infected chickens, suggesting that targeting HMGB1 could be a new strategy for treating chronic respiratory diseases.
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Mycoplasma gallisepticum (MG) is the main pathogen of chronic respiratory disease (CRD), an infectious disease in chickens with high morbidity. Exosomal miRNAs are emerging as important regulators in host immune response to microbial invasion. Previously, we found that gga-miR-193a was significantly up-regulated in exosomes from MG-infected primary chicken type II pneumocytes (CP-IIs).

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Article Synopsis
  • Mycoplasma gallisepticum (MG) is a major cause of chronic respiratory disease in chickens, and is influenced by long non-coding RNAs (lncRNAs) that can regulate gene expression through competition with microRNAs (miRNAs).
  • Researchers discovered that the miRNA miR-33-5p is up-regulated in MG-infected chicken embryonic lungs and negatively correlates with the lncRNA Lnc90386, which modulates the effects of miR-33-5p on JNK1, a protein involved in apoptosis and inflammation.
  • The study concludes that Lnc90386 acts as a competing endogenous RNA (ceRNA) by binding to miR-33-5p
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Mycoplasma gallisepticum (MG) is the primary etiologic agent of chronic respiratory disease (CRD) in chickens. Respiratory tract inflammation and apoptosis are the main features of CRD. Andrographolide (Andro), a natural small molecule compound, is known for its excellent anti-pathogenic and anti-inflammatory properties.

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The ultrafast nonlinear optical response of two 1,3-indandione derivatives (INB3 and INT3) was systematically investigated by the femtosecond Z-scan and pump-probe technique at multiple visible and near infrared wavelengths. Both compounds show strong broadband nonlinear absorption (NLA) and different wavelength-dependent two-photon absorption (TPA) characteristics in the range of 650-1100 nm. The TPA cross section of trithiophene-based compound INT3 was found to be larger than that of triphenylamine-based compound INB3 in the red region (650-800 nm), which is attributed to its longer π-conjugated structure and better molecular planarity.

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  • Mycoplasma gallisepticum (MG) is the main cause of chronic respiratory diseases in chickens, and antibiotics are commonly used to manage these infections, though they can lead to drug resistance issues.
  • Glycyrrhizic acid (GA), derived from licorice, shows potential as a natural alternative by significantly inhibiting the expression of harmful genes involved in MG infection, as well as reducing inflammation and cell death in affected tissues.
  • The study indicates that GA acts mainly through specific signaling pathways (JNK and p38) to prevent inflammation and tissue damage caused by MG, suggesting it could be a safer option for poultry health management.
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  • Mycoplasma gallisepticum (MG) is a harmful pathogen in poultry that can lead to Chronic Respiratory Disease (CRD), impacting the poultry industry economically.
  • This study focused on the role of gga-miR-24-3p, which is significantly increased during MG infection, and its effects on cellular mechanisms, particularly involving the downregulation of Ras-related protein-B (RAP1B).
  • The findings suggest that gga-miR-24-3p promotes inflammation and apoptosis in chicken fibroblast cells, while inhibiting cell proliferation, indicating a new mechanism of resistance against MG infection in vitro.
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Mycoplasma gallisepticum (MG) is a major poultry pathogen that can induce Chronic Respiratory Disease (CRD) in chickens, causing serious economic losses in the poultry industry worldwide. Increasing evidence suggests that microRNAs (miRNAs) act as a vital role in resisting microbial pathogenesis and maintaining cellular mechanism. Our previous miRNAs sequencing data showed that gga-miR-223 expression level significantly decreased in MG-infected chicken lungs.

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A hybrid sludge conditioning strategy with electrooxidation and Fe(II) addition was used for heavy metal removal from sewage sludge and industrial sludge, with simultaneous sludge dewatering and stabilization. With the addition of 82 mg/g DS Fe(II) and treatment time of 4.5 h, heavy metal removals of 72.

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Mycoplasma gallisepticum (MG) is the primary etiological agent of chicken chronic respiratory disease (CRD), which mainly causes inflammatory damage of the host respiratory system. Previous studies suggest that puerarin (PUE) plays a pivotal regulatory role in inflammatory diseases, whereas the impacts of PUE on MG-induced inflammation remain unclear. This study investigated the effects of PUE on MG-HS infection in vitro and in vivo and indicated its potential therapeutic and preventive value.

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