Publications by authors named "Yinge Zhan"
Article Synopsis
- G1 is a specific agonist for the GPR30 receptor that shows promise in reducing obesity and managing glucose levels, but its effects have only been tested in normal diet settings, not high-fat diets.
- In a study using ovariectomized mice on a high-fat diet, G1 treatment led to weight loss but also increased blood glucose and insulin resistance.
- The interaction between G1 treatment and the high-fat diet affected fat metabolism and key enzymes, raising concerns about G1's potential negative impact on blood sugar regulation and the need for further research on its side effects.
Article Synopsis
- The lymphatic system is a low-pressure fluid network that works alongside the circulatory system, helping maintain tissue fluid balance, transport immune cells, and absorb lipids.
- Recent research highlights the importance of cardiac lymphatic vessels, suggesting that promoting their growth (lymphangiogenesis) could help treat various cardiovascular diseases.
- The article reviews the development, functions, and interactions of cardiac lymphatics with conditions like atrial fibrillation and heart failure, while exploring potential therapies targeting these vessels for better cardiovascular health.
Article Synopsis
- Recent research indicates that fat accumulation in the interatrial septum (IAS) may play a significant role in causing atrial fibrillation (AF), and this study explores how transesophageal echocardiography (TEE) can effectively assess IAS fat in AF patients.
- The imaging results showed greater IAS fat volume relative to epicardial fat in patients with persistent AF compared to those with paroxysmal AF, suggesting a link between IAS adiposity and AF severity.
- Histological analysis from autopsy samples revealed thicker IAS in AF patients and highlighted changes like "myocardial splitting" due to IAS fat infiltration, which may contribute to atrial cardiomyopathy associated with AF.
Background: Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. Although fat is currently considered to be a risk factor for AF and a pathogenic link between epicardial fat tissue (EFT) and AF has been speculated, there are currently few clinical studies and literature data domestically or abroad.
Objective: This study conducted a meta-analysis of observational case series studies to verify the relationship between atrial fibrillation and EFT and to strengthen the predictive value of EFT in the occurrence, development, and postablative recurrence of AF.
Background: G-protein-coupled ER (GPR30) plays an important role in cardioprotection. Recent studies have shown that the GPR30-specific agonist G-1 reduces the degree of myocardial fibrosis in rats with myocardial infarction, reduces the morbidity associated with atrial fibrillation, and inhibits the proliferation of cardiac fibroblasts in animal experiments. Nevertheless, the underlying mechanism of myocardial fibrosis and atrial fibrillation remains unclear.
View Article and Find Full Text PDFBackground: Rikkunshito (RKT), a traditional herbal medicine, has been demonstrated to exert anti-inflammatory, anti-apoptotic, and anti-fibrotic effects in several organs. This study tested the hypothesis that RKT can suppress angiotensin II (AngII)-induced inflammatory atrial fibrosis and ameliorate enhanced vulnerability to atrial fibrillation (AF).
Methods: Eight-week-old male C57BL/6 mice were subcutaneously infused with either vehicle or AngII (2.