Publications by authors named "Yingdan Wang"
Article Synopsis
- * A bispecific antibody called G7-Fc, developed using 7F3 and another neutralizing antibody GW01, shows strong effectiveness against 28 SARS-CoV-2 variants and offers protective benefits in animal models infected with the XBB.1 variant.
- * Structural analysis of G7-Fc reveals its ability to target two different parts of the virus's receptor-binding domain, making it a promising candidate for preventing
Article Synopsis
- * Researchers compared 111 girls, including those with CPP, peripheral precocious puberty (PPP), and normal development, measuring various hormone levels alongside conducting pelvic ultrasounds.
- * The findings indicated that girls with CPP had significantly higher serum irisin levels, which correlated with other hormonal and growth indicators, suggesting that measuring irisin can enhance CPP diagnosis accuracy.
Article Synopsis
- This study examined how surgical compliance impacts the survival outcomes of meningioma patients, analyzing a large cohort of over 122,000 cases from a medical database.
- Results indicated that 92.4% of patients had good surgical compliance, which significantly correlated with better overall survival rates compared to those with poor compliance.
- The researchers developed a predictive model based on seven factors (age, sex, race, tumor behavior, size, family income, and residential setting) to understand and improve surgical adherence among these patients.
Article Synopsis
- Xinjiang is a major hotspot for pulmonary tuberculosis (PTB) in China, with infections occurring through both direct contact with active PTB individuals and environmental exposure to contaminated Mycobacterium tuberculosis.
- Researchers developed a dynamic transmission model that accounts for the differences in transmission capability between smear-positive (PTB+) and smear-negative (PTB-) individuals, fitting the model to case data from 2008 to 2017 using advanced statistical methods.
- The study finds a basic reproduction number of 2.447 for PTB transmission, indicating a prevalent problem, and suggests strategies such as reducing transmission rates and improving screening and treatment efforts to better manage PTB in the region.
The ectodomain of influenza matrix protein 2 (M2e) is a promising target for the development of universal prophylactic and therapeutic agents against influenza viruses of different subtypes. We constructed three M2e-specific monoclonal antibody variants, M2A1-1 (IgG1), M2A1-2a (IgG2a), M2A1-2b (IgG2b), which have the same Fab region targeting the M2e epitope but different isotypes, and compared their protective efficacy in influenza PR8-infected mice. We found that anti-M2e antibodies provided protection against influenza virus in a subtype-dependent manner, with the IgG2a variant providing significantly better protection with lower virus titers and milder lung injury than IgG1 and IgG2b isotypes.
View Article and Find Full Text PDFIn this paper, we separately constructed ARIMA, ARIMAX, and RNN models to determine whether there exists an impact of the air pollutants (such as PM2.5, PM10, CO, O3, NO2, and SO2) on the number of pulmonary tuberculosis cases from January 2014 to December 2018 in Urumqi, Xinjiang. In addition, by using a new comprehensive evaluation index DISO to compare the performance of three models, it was demonstrated that ARIMAX (1,1,2) × (0,1,1)12 + PM2.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on creating bispecific antibodies to target the highly mutated Omicron variants (BA.1 and BA.2) that show reduced effectiveness against current COVID-19 vaccines and neutralizing antibodies (NAbs).
- Researchers engineered 10 different bispecific antibodies from existing non-Omicron NAbs, with 8 demonstrating strong binding to the Omicron receptor and the ability to neutralize Omicron and other related variants effectively.
- Detailed analysis of the antibodies revealed their capacity to accommodate specific Omicron mutations, and structural studies identified how the bispecific antibodies facilitate a conformational change that enhances their viral neutralization capabilities.
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern, including Alpha (B.1.1.
View Article and Find Full Text PDFArticle Synopsis
- This study explores a method for managing heat using a three-qubit system along with a coherent auxiliary bath (CAB) to control heat transfer to a target thermal bath (TTB).
- The research reveals that the heat current between the system and TTB can be manipulated by adjusting the coupling strength with the CAB, and this manipulation also depends on the quantum coherence of the auxiliary elements.
- Additionally, the system can function as a versatile thermal device—acting as a heat amplifier, suppressor, switcher, and refrigerator when coupled with the CAB—while it only serves as a thermal suppressor with a traditional thermal bath.
Zearalenone (ZEN) is one of the most widely distributed harmful mycotoxins produced by Fusarium species, especially deposited in corn oil. In this study, we systematically tracked the changes of ZEN in the refining of corn oil, and especially during neutralization process. An alkali neutralization process could remove certain amounts of ZEN that was much more than that of others refining steps.
View Article and Find Full Text PDFArticle Synopsis
- Diabolical points are critical in various scientific fields such as Berry phase theory, photonics, and material science, particularly in graphene with its Dirac points.
- This study focuses on diabolical points within an optomechanical system using multiple scatterers in an optical cavity, resembling experimental setups like micro-toroidal rings.
- It reveals that optomechanical coupling becomes non-analytic near the diabolical point, showcasing a topological phase linked to mechanical motion, and introduces a simple quantum model related to the behavior of spin particles in a quantum dot.
We show how strong steady-state entanglement can be achieved in a three-mode optomechanical system (or other parametrically coupled bosonic system) by effectively laser cooling a delocalized Bogoliubov mode. This approach allows one to surpass the bound on the maximum stationary intracavity entanglement possible with a coherent two-mode squeezing interaction. In particular, we find that optimizing the relative ratio of optomechanical couplings, rather than simply increasing their magnitudes, is essential for achieving strong entanglement.
View Article and Find Full Text PDFArticle Synopsis
- The study explores using a mechanical resonator to transfer quantum states between two types of electromagnetic cavities, like optical and microwave cavities.
- An effective mechanically dark mode is identified that remains unaffected by mechanical dissipation, which boosts the efficiency of state transfer between cavities.
- The authors present straightforward mathematical formulas to calculate the fidelity of transferring both Gaussian and non-Gaussian quantum states.
Two correlation patterns as indicators for underlying dynamics of complex systems.
Phys Rev E Stat Nonlin Soft Matter Phys
January 2005
Article Synopsis
- Two spatial correlation patterns, known as fixed-to-arbitrary and neighboring bin correlation patterns, are introduced as measurement techniques.
- These patterns are shown to effectively distinguish between correlated and uncorrelated random processes without being affected by scale.
- The text also explores how these correlation patterns can be applied to analyze high multiplicity events that occur during relativistic heavy ion collisions.