A cross-tissue transcriptome-wide association study identifies new key genes in ischemic stroke.

Background: Ischemic stroke (IS) is an important disease causing death and disability worldwide, and further investigation of IS-related genes through genome-wide association study (GWAS) data is valuable.

Methods: The study included GWAS data from 62,100 IS patients of European origin and 1,234,808 controls in a cross-tissue transcriptome association study (TWAS). A joint analysis was first performed by the Unified Test for Molecular Markers (UTMOST) and FUSION methods.

Influence of obesity on microvascular obstruction and the myocardial area at risk in patients with ST-segment elevation myocardial infarction.

Objective: To explore the influence of obesity on microvascular obstruction (MVO) and myocardial area at risk (AAR) in patients with ST-segment elevation myocardial infarction (STEMI).

Methods: A retrospective analysis was performed on patients with first-episode STEMI hospitalized at Nanjing University of Traditional Chinese Medicine between May 2020 and May 2022. Patients were categorized into normal weight, overweight, and obese groups based on their body mass index (BMI).

Array-optimized artificial olfactory sensor enabling cost-effective and non-destructive detection of mycotoxin-contaminated maize.

The MobileNetV3-based improved sine-cosine algorithm (ISCA-MobileNetV3) was combined with an artificial olfactory sensor (AOS) to address the redundancy in olfactory arrays, thereby achieving low-cost and high-precision detection of mycotoxin-contaminated maize. Specifically, volatile organic compounds of maize interacted with unoptimized AOS containing eight porphyrins and eight dye-attached nanocomposites to obtain the scent fingerprints for constructing the initial data set. The optimal decision model was MobileNetV3, with more than 98.

Interpretable machine learning-accelerated seed treatment using nanomaterials for environmental stress alleviation.

Crops are constantly challenged by different environmental conditions. Seed treatment using nanomaterials is a cost-effective and environmentally friendly solution for environmental stress mitigation in crop plants. Here, 56 seed nanopriming treatments are used to alleviate environmental stresses in maize.

Olfactory visualization sensor system based on colorimetric sensor array and chemometric methods for high precision assessing beef freshness.

Beef is easily spoiled, resulting in foodborne illness and high societal costs. This study proposed a novel olfactory visualization system based on colorimetric sensor array and chemometric methods to detect beef freshness. First, twelve color-sensitive materials were immobilized on a hydrophobic platform to acquire scent information of beef samples according to solvatochromic effects.

Recent advances in the application of Raman spectroscopy for fish quality and safety analysis.

Fish is one of the highly demanded aquatic products, and its quality and safety play a pivotal role in daily diet. However, the possible hazardous substance in perishable fish both in pre- and postharvest periods may decrease their values and pose a threat to public health. Laborious and expensive traditional methods drive the need of developing effective tools for detecting fish quality and safety properties in a rapid, nondestructive, and effective manner.

Effects of Anterior Borderzone Angle Grading on Predicting the 90-Day Prognosis After Recanalization of Acute Middle Cerebral Artery Occlusion.

This work explores collateral circulation metrics, such as the anterior borderzone angle grading (ABZA-grading), as a predictor of the prognosis in patients with acute middle cerebral artery occlusion (MCAO) following endovascular treatment (EVT). Clinical data from 108 patients with acute MCAO, treated by EVT, were retrospectively analyzed. In patients with MCAO, ABZA is the angle between the median line of the sagittal sinus and the borderzone of the pial arterioles of ACA and MCA, and the ABZA/23.

Qualitative identification of the edible oil storage period using a homemade portable electronic nose combined with multivariate analysis.

Background: The edible oil storage period is one of the important indicators for evaluating the intrinsic quality of edible oil. The present study aimed to develop a portable electronic nose device for the qualitative identification of the edible oil storage period. First, four metal oxide semiconductor gas sensors, comprising TGS2600, TGS2611, TGS2620 and MQ138, were selected to prepare a sensor array to assemble a portable electronic nose device.

Determination of acid value during edible oil storage using a portable NIR spectroscopy system combined with variable selection algorithms based on an MPA-based strategy.

Background: The acid value is an important indicator for evaluating the quality of edible oil during storage. This study employs a portable near-infrared (NIR) spectroscopy system to determine the acid value during edible oil storage. Four MPA-based variable selection methods, namely competitive adaptive reweighted sampling (CARS), the variable iterative space shrinkage approach (VISSA), iteratively variable subset optimization (IVSO), and bootstrapping soft shrinkage (BOSS) were introduced to optimize the preprocessed NIR spectra.

High-precision identification of the actual storage periods of edible oil by FT-NIR spectroscopy combined with chemometric methods.

The actual storage period of edible oil is one of the important indicators of edible oil quality. A high-precision identification method based on the near-infrared (NIR) spectroscopy technique for the actual storage period of edible oil is proposed in this study. Firstly, a Fourier transform NIR (FT-NIR) spectrometer was used to collect NIR spectra of edible oil samples in different storage periods, and the obtained spectra were pretreated by standard normal transformation (SNV).

Pholiotone A, a new polyketide derivative from sp.

Pholiotone A (), a new polyketide derivative, with tetrahydrobenzofuran-4(2)-one skeleton, together with four known compounds, trichodermatides A () and B () and koninginins B () and E (), were isolated from the crude extract of sp. The structures of all the isolated compounds were determined mainly by NMR experiments, the modified Mosher method and electronic circular dichroism (ECD) calculations. The antifungal and cytotoxicity of all isolates were evaluated.