Publications by authors named "Yingchang Xue"
Myocardial strain is regulated by cardiac preload in the early stage of sepsis.
BMC Cardiovasc Disord
August 2024
Background: Owing to a lack of data, this study aimed to explore the effect of cardiac preload on myocardial strain in patients with sepsis.
Methods: A total of 70 patients with sepsis in intensive care unit (ICU) of a tertiary teaching hospital in China from January 2018 to July 2019 and underwent transthoracic echocardiography were enrolled. Echocardiographic data were recorded at ICU admission and 24 h later.
Article Synopsis
- The study investigates the role of apolipoprotein C3 (ApoC3) in regulating inflammation and tissue damage in acute lung injury (ALI) using a mouse model induced by lipopolysaccharide (LPS).
- Results showed that higher levels of ApoC3 in lung tissue correlated with increased inflammation, while silencing ApoC3 led to reduced inflammatory factors and less tissue damage, indicating its pro-inflammatory role.
- The research suggests that ApoC3's effects may be mediated through the TLR/NF-κB signaling pathway, highlighting potential pathways for therapeutic intervention in ALI.
Sepsis can easily cause acute kidney injury (AKI) and seriously endanger human health. This article aims to investigate and study the role of microRNA-665 (miR-665) in septic AKI and the underlying molecular mechanism. Lipopolysaccharide (LPS) was used to construct cell and animal models of septic AKI.
View Article and Find Full Text PDF[Effects of exogenous hydrogen sulfide on intestinal function in rabbits after cardiopulmonary resuscitation].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2018
Objective: To investigate the effect of exogenous hydrogen sulfide (HS) on intestinal mucosal barrier after cardiopulmonary resuscitation (CPR) in cardiac arrest (CA) rabbits.
Methods: Forty-four male New Zealand rabbits were divided into sham operation group (Sham group, n = 12), post-cardiac arrest syndrome (PCAS) group (n = 16) and H2S intervention group (PCAS+NaHS, n = 16) according to random number table method. The rabbit model of PCAS was established by tracheal clamping and suffocation, and CPR was started at 5 minutes after CA.