Network analysis of stress and stigma symptoms and their associations with quality of life among Chinese female infertility patients.

Background: This study has employed network analysis while investigating the interrelationships among stress and stigma symptoms and their associations with quality of life among Chinese female infertility patients.

Methods: In this cross-sectional study, 428 female patients who visited the Department of Reproductive Center of Dalian Women and Children's Medical Group with chief complaints of infertility symptoms were recruited using convenience sampling from November 2022 to December 2023. Fertility-related stress and stigma status were examined by the Fertility Problem Inventory (FPI) and Infertility Stigma Scale (ISS), respectively.

Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis.

Diarrhoeal disease caused by Cryptosporidium is a major cause of morbidity and mortality in young and malnourished children from low- and middle-income countries, with no vaccine or effective treatment. Here we describe the discovery of EDI048, a Cryptosporidium PI(4)K inhibitor, designed to be active at the infection site in the gastrointestinal tract and undergo rapid metabolism in the liver. By using mutational analysis and crystal structure, we show that EDI048 binds to highly conserved amino acid residues in the ATP-binding site.

Origin and Geochemical Characterization of Groundwater from Coal Seam: A Case Study of Balasu Coalfield, Ordos Basin.

The hydrochemical characteristics of groundwater are of great significance for studying the source, development, and utilization of groundwater. This study investigated the characteristics of anions and cations, total dissolved solids (TDS), hydrochemical types, and hydrogen and oxygen isotopes of surface water and groundwater in the Balasu coalfield. By conducting experiments using inductively coupled plasma emission electron spectrometry, ion chromatography, acid-base titration, and gravimetric analysis, the characteristics of ion concentration and TDS in different aquifers were analyzed to determine the possible source of groundwater in C2 (number 2 coal seam in Yan'an Formation).

Anti-Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy.

Importance: Whether anti-Helicobacter pylori treatment can provide survival benefits for patients with gastric cancer who are diagnosed with H pylori infection is an area with limited research.

Objective: To explore the potential survival benefits of anti-H pylori treatment after radical gastrectomy in patients with gastric cancer and presurgical confirmation of H pylori infection.

Design, Setting, And Participants: This retrospective cohort study was conducted using data from patients with gastric cancer treated between January 1, 2010, and December 31, 2018, and followed up for outcome ascertainment until May 19, 2021.

Adaptive river flow measurement method based on spatiotemporal image velocimetry and optical flow.

This paper proposes an adaptive river discharge measurement method based on spatiotemporal image velocimetry (STIV) and optical flow to solve the problem of blurred texture features and limited measurement accuracy under complex natural environmental conditions. Optical flow tracking generates spatiotemporal images by following the flow mainstream direction of rivers with both regular and irregular natural banks. A texture similarity function filtering method effectively enhances spatiotemporal texture features.

Detection of pesticide residues on flexible and transparent fluorinated polyimide film based on surface-enhanced Raman spectroscopy technology.

Background: Excessive pesticide residues will seriously endanger human health. The complexity and lag of the current popular analytical methods hinder the timeliness of food safety analysis. Surface-enhanced Raman scattering (SERS) was an ultra-sensitive vibration spectroscopy technology with the advantages of less time cost, non-destructive and semi-quantitative detection, which has attracted much attention in the rapid field detection of pesticide residue.

Flexible, foldable and transparent SERS film with high sensitivity and signal homogeneity via silver ion exchange and in-situ reduction.

The adhesion between metal plasma and substrate was the key of surface-enhanced Raman scattering (SERS) technology. The preparation of ideal SERS substrate with multiple advantages such as high sensitivity and good signal reproducibility was still the focus of research. A flexible foldable and transparent fluorinated polyimide/silver NPs (FPI@Ag) SERS film was fabricated by the ion exchange and in-situ reduction method in this work.

Combined Use of Tumor Markers in Gastric Cancer: A Novel Method with Promising Prognostic Accuracy and Practicality.

Background: The effect of a single tumor marker on the prognosis of gastric cancer patients is not ideal. This study explored a novel prognostic assessment method for gastric cancer (GC) patients using a combination of three important tumor markers (CEA, CA72-4, and CA19-9).

Method: Data from 1966 GC patients who underwent curative gastrectomy at Sun Yat-Sen University Cancer Center (Guangzhou, China) were included.

Selective removal of Cr(VI) by tannic acid and polyethyleneimine modified zero-valent iron particles with air stability.

In this study, a new composite adsorbent for Cr(VI) removal was developed by immobilizing polyethyleneimine (PEI) on the surface of zero-valent iron (ZVI) particles with tannic acid (TA) as a stabilizer. The adsorbent (denoted as Fe-TA-PEI-10) was easy to prepare and regenerate, requiring no conditions for storage. It was found to be particularly effective for Cr(VI) removal from wastewater via reduction and adsorption.

Evaluating relapse-free survival as an endpoint for overall survival in adjuvant immunotherapy trials.

Background: Relapse-free survival (RFS) has been considered a primary endpoint to assess the effects of immunotherapy in the adjuvant setting among patients with early-stage disease. However, it is not clear whether RFS is a valid surrogate endpoint for overall survival (OS) in this clinical context.

Methods: Phase II or III clinical trials of adjuvant immunotherapy that reported hazard ratios on OS and RFS were identified.

Prognostic factors and the necessity of chemotherapy for stage II gastric cancer: a model based on multicenter retrospective study.

Background: This study aimed to construct a prognostic model for prognosis prediction and assess the response to adjuvant chemotherapy (ACT) of stage II gastric cancer (GC) patients on high and low survival risk stratifications.

Methods: We retrospectively reviewed 547 stage II gastric cancer patients who underwent D2 radical gastrectomy from January 2009 to May 2017 in Sixth Affiliated Hospital of Sun Yat-Sen University (SAH-SYSU), the Fujian Medical University Union Hospital (FJUUH), and the Sun Yat-Sen University Cancer Center (SYSUCC).The propensity score matching (PSM) of all variables was performed to balance selective bias between ACT and surgery alone (SA) groups.

Adjuvant Chemotherapy for Patients with Adenocarcinoma of the Esophagogastric Junction: A Retrospective, Multicenter, Observational Study.

Background: Although the incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing since the past decade, the proportion of AEG cases in two previous clinical trials (ACTS-GC and CLASSIC) that investigated the efficacy of adjuvant chemotherapy was relatively small. Therefore, whether AEG patients can benefit from adjuvant chemotherapy remains unclear.

Methods: Patients who were diagnosed with pathological stage II/III, Siewert II/III AEG, and underwent curative surgery at three high-volume institutions were assessed.

LAG3-PD1 or CTLA4-PD1 Inhibition in Advanced Melanoma: Indirect Cross Comparisons of the CheckMate-067 and RELATIVITY-047 Trials.

To compare the inhibition of LAG3-PD1 versus the inhibition of CTLA-4-PD1 in patients with previously untreated advanced melanoma. The individual participant data (IPD) were extracted from the KM plots using a graphical reconstructive algorithm. Log-rank, Cox proportional hazard model, Bayesian hierarchical model with time-varying hazard ratio (HR) effect, and restricted mean survival time (RMST) were performed to estimate survival benefits.

Indications for Adjuvant Chemotherapy in Stage II Gastric Cancer After D2 Gastrectomy-A Chinese Multicenter Study.

Background: The benefit of adjuvant chemotherapy (AC) for patients with stage II gastric cancer remains controversial. This study aimed to explore the indications for adjuvant chemotherapy in patients with stage II gastric cancer by constructing an individual prediction model.

Patients And Methods: In this Chinese multicenter study, a total of 1012 patients with stage II gastric cancer after D2 radical gastrectomy were retrospectively analyzed.

Novel Perylene-3, 4, 9, 10-tetracarboxylic dianhydride modified Zr-MOFs/Graphene oxide membrane for dye wastewater treatment.

A new type of composite membrane was prepared through the vacuum filtration self-assembly, in which, graphene oxide (GO) was the basic material, and the horizontal insertion material is product of perylene-3, 4, 9, 10-tetracarboxylic dianhydride (PTCDA) and UiO-66-NH (PTCDA-UiO-66-NH). The leading role of Π-Π conjugate, auxiliary effect of hydrogen bonding during membrane preparation have been confirmed through Fourier transform infrared spectroscopy (FTIR), UV-visible spectrophotometer, Raman spectroscopy, and X-ray diffraction (XRD). The prepared GO@PTCDA-UiO-66-NH membrane had new nodular structure compared to GO membrane by scanning electron microscopy (SEM) and atomic force microscopy (AFM), which promoted the water transport.

A nomogram to predict risk of lymph node metastasis in early gastric cancer.

Lymph node (LN) metastasis is known as one of the most important prognostic factors for early gastric cancer (EGC) patients. Patients without LNM normally have better prognosis. However, there is no evaluation criteria to accurately assess the possibility of LN metastasis.

Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.

The soaring global prevalence of diabetes makes it urgent to explore new drugs with high efficacy and safety. Nanomaterial-derived bioactive agents are emerging as one of the most promising candidates for biomedical application. In the present study, we investigated the anti-diabetic effects of a functionalized gadofullerene (GF) using obese db/db and non-obese mouse model of type 2 diabete mellitus (MKR) mouse type 2 diabetes mellitus (T2DM) models.

Survival analysis of stage II gastric cancer patients after D2 gastrectomy: a Chinese people-based research.

Objective: The benefit of adjuvant chemotherapy is still controversial for stage II gastric cancer patients. This study aims to identify prognostic factors to guide individualized treatment for stage II gastric cancer patients.

Methods: We retrospectively reviewed 1121 stage II gastric cancer patients who underwent D2 radical gastrectomy from 2007 to 2017 in the Sixth Affiliated Hospital of Sun Yat-sen University, FuJian Medical School Affiliated Union Hospital and Sun Yat-sen University Cancer Center.