Effect of heat treatment on microstructure and mechanical properties of selective laser melted Inconel 718 alloy.

In this study, we conducted two heat treatment processes, namely double aging (DA) and solid solution followed by double aging (SA), on the Inconel 718 alloy fabricated by selective laser melting (SLM). The aim was to investigate the microstructure evolution and mechanical properties of Inconel 718 under different heat treatment conditions. To achieve this, we employed advanced techniques such as Scanning Electron Microscope (SEM), electron backscattered diffraction (EBSD), energy dispersive spectroscopy (EDS), x-ray diffraction (XRD), Tofwerk time-of-flight secondary ion mass spectrometer (TOF-SIMS), and transmission electron microscopy (TEM).

Admission Blood Glucose Associated with In-Hospital Mortality in Critically III Non-Diabetic Patients with Heart Failure: A Retrospective Study.

Background: Heart failure (HF) is a primary public health issue associated with a high mortality rate. However, effective treatments still need to be developed. The optimal level of glycemic control in non-diabetic critically ill patients suffering from HF is uncertain.

LDCT image denoising algorithm based on two-dimensional variational mode decomposition and dictionary learning.

Low-dose X-CT scanning method effectively reduces radiation hazards, however, reducing the radiation dose will introduce noise and artifacts during the projection process, resulting in a decrease in the quality of the reconstructed image. To address this problem, we combined 2D variational modal decomposition and dictionary learning. We proposed a low-dose CT (LDCT) image denoising algorithm based on an improved K-SVD algorithm with image decomposition.

Crystal structure and function analysis of 6-phosphogluconate dehydrogenase in Mycobacterium tuberculosis.

6-phosphogluconate dehydrogenase (6PGDH) is an essential enzyme in energy metabolism and redox reactions, and represents a potential drug target for the development of therapies targeting trypanosomes, plasmodium, or other pathogens. Tuberculosis, caused by Mycobacterium tuberculosis, is a contagious disease that severely affects human health, with approximately one-third of the world's population infected. However, the protein structure, exact oligomeric state, and catalytic mechanism of 6PGDH in Mycobacterium tuberculosis (Mt6PGDH) have remained largely unknown.

Fast high quality computational ghost imaging based on saliency variable sampling detection.

Fast computational ghost imaging with high quality and ultra-high-definition resolution reconstructed images has important application potential in target tracking, biological imaging and other fields. However, as far as we know, the resolution (pixels) of the reconstructed image is related to the number of measurements. And the limited resolution of reconstructed images at low measurement times hinders the application of computational ghost imaging.

Increasing the Light Extraction Efficiency of Organic Light-Emitting Devices by Electrochemically Corroded Patterned Substrates.

A substrate with microstructure can increase the light extraction efficiency of OLEDs. However, the present preparation methods for micro- and nanostructures are not suited for broad-area manufacturing. In this research, we suggested an electrochemical etching approach to patterning Si substrates and effectively generated a vast area of micro-/nanostructures on the surface of Si.

Physiological and transcriptomic analyses reveal that phytohormone pathways and glutathione metabolism are involved in the arsenite toxicity response in tomatoes.

The main forms of inorganic arsenic (As) in soil are arsenate [As(V)] and arsenite [As(III)]. Both forms inhibit plant growth. Here, we investigate the effects of As(III) toxicity on the growth of tomatoes by integrating physiological and transcriptomic analyses.

The accuracy of simplified calculation of mechanical power: a simulation study.

Background: Mechanical ventilation (MV) is an important life-saving method in the intensive care unit (ICU). A lower mechanical power (MP) is associated with a better MV strategy. However, traditional MP calculating methods are complicated, and algebraic formulas seem to be rather practical.

An investigation on the respiratory mechanics of mechanically ventilated patients during spontaneous breathing trials with enhanced low-level pressure support ventilation.

Introduction: Low-level pressure support ventilation (PSV) is most commonly adopted in spontaneous breathing trials (SBTs), and some have proposed setting the positive end-expiratory pressure (PEEP) to 0 cmH O in order to shorten the observation time of SBTs. This study aims to investigate the effects of two PSV protocols on the patients' respiratory mechanics.

Material And Method: A prospective randomized self-controlled crossover design was adopted in this study, which involved enrolling 30 difficult-to-wean patients who were admitted to the intensive care unit of the First Affiliated Hospital of Guangzhou Medical University between July 2019 and September 2021.

GATR: A Road Network Traffic Violation Prediction Method Based on Graph Attention Network.

Prediction of traffic violations plays a key role in transportation safety. Combining with deep learning to predict traffic violations has become a new development trend. However, existing methods are based on regular spatial grids which leads to a fuzzy spatial expression and ignores the strong correlation between traffic violations and road network.

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism.

Metabolic reprogramming is a hallmark of cancer, including lung cancer. However, the exact underlying mechanism and therapeutic potential are largely unknown. Here we report that protein arginine methyltransferase 6 (PRMT6) is highly expressed in lung cancer and is required for cell metabolism, tumorigenicity, and cisplatin response of lung cancer.

PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis.

Previous studies have shown that phosphoinositide 3-kinase enhancer-activating Akt (PIKE-A) is involved in the regulation of several biological processes in cancer. In our previous study, we demonstrated a crucial function of PIKE-A in cancer energy metabolism by regulating pentose phosphate pathway (PPP) flux. However, whether PIKE-A regulates energy metabolism through affecting mitochondrial changes are poorly understood.

Ultra-Smooth and Efficient NiO/Ag/NiO Transparent Electrodes for Flexible Organic Light-Emitting Devices.

We demonstrate highly flexible and efficient organic light-emitting devices (OLEDs) using an ultra-smooth NAN anode. A template-stripping process was employed to create an ultra-smooth NAN anode on a photopolymer substrate. The flexible OLEDs obtained by this method maintained good electroluminescent properties and mechanical stability after bending.

Functional metabolome profiling may improve individual outcomes in colorectal cancer management implementing concepts of predictive, preventive, and personalized medical approach.

Objectives: Colorectal cancer (CRC) is one of the most common solid tumors worldwide, but its diagnosis and treatment are limited. The objectives of our study were to compare the metabolic differences between CRC patients and healthy controls (HC), and to identify potential biomarkers in the serum that can be used for early diagnosis and as effective therapeutic targets. The aim was to provide a new direction for CRC predictive, preventive, and personalized medicine (PPPM).

Higher Light Extraction Efficiency in Organic Light-Emitting Devices by Employing 2D Periodic Corrugation.

Photons trapped in the form of waveguide (WG) modes associated with the organic-organic interface and in the form of surface plasmon polariton (SPP) modes associated with the metallic electrode-organic interface result in a large energy loss in organic light-emitting devices (OLEDs). Introducing gratings onto the metallic electrode is especially crucial for recovering the power lost to the associated SPP modes. In our research, we demonstrate the efficient outcoupling of SPP modes in TE mode by two-dimensional (2D) grating, which cannot excited in one-dimensional (1D) grating OLED.

Optimal Positive End Expiratory Pressure Levels in Ventilated Patients Without Acute Respiratory Distress Syndrome: A Bayesian Network Meta-Analysis and Systematic Review of Randomized Controlled Trials.

To find the optimal positive end expiratory pressure (PEEP) in mechanical ventilated patients without Acute Respiratory Distress Syndrome (ARDS), we conducted a Bayesian network meta-analysis and systematic review of randomized controlled trials (RCTs) comparing different level of PEEP based on a novel classification of PEEP level: ZEEP group (PEEP = 0 cm H2O); lower PEEP group (PEEP = 1-6 cm H2O); intermediate PEEP group (PEEP = 7-10 cm H2O); higher PEEP group (PEEP > 10 cm H2O). Twenty eight eligible studies with 2,712 patients were included. There were no significant differences in the duration of mechanical ventilation between higher and intermediate PEEP (MD: 0.

PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.

Reprogramming of energy metabolism is a hallmarkofcancer, and the pentose phosphate pathway (PPP) is a major glucose metabolic pathway important for meeting the cellular demands of biosynthesis and anti-oxidant defense. Our previous study showed that phosphoinositide 3-kinase enhancer-activating Akt (PIKE-A) plays an important role in glioblastoma cell survival and growth under cellular energy stress condition. However, the crucial functions of PIKE-A in cancer energy metabolism are poorly understood.

Critical Review of the Scientific Evidence and Recommendations in COVID-19 Management Guidelines.

Background: Little is known about the quality and potential impacts of the guidelines for coronavirus disease 2019 (COVID-19) management.

Methods: We systematically searched PubMed, Web of Science, Cochrane Library, guideline databases, and specialty society websites to evaluate the quality of the retrieved guidelines using the Appraisal of Guidelines for Research and Evaluation II.

Results: A total of 66 guidelines were identified.

Reverse Trigger in Ventilated Non-ARDS Patients: A Phenomenon Can Not Be Ignored!

Introduction: The role of reverse trigger (RT) was unknown in ventilated non-acute respiratory distress syndrome (ARDS) patients. So we conducted a retrospective study to evaluate the incidence, characteristics and physiologic consequence of RT in such population.

Method: Six ventilated non-ARDS patients were included, the esophageal balloon catheter were placed for measurements of respiratory mechanics in all patients.

Analgesic Pump Tubing Securement to Prevent Dislodgement of Peripheral Vein Indwelling Catheter.

Purpose: This study aims to compare the incidence of complications when using a new approach to secure an indwelling peripheral venous catheter (PVC), involving tying of the tube with a surgical knot at two places and several layers of elastic adhesive bandage, with a standard approach using sterile, transparent, and protective film.

Methods: This study enrolled 311 consecutive adults undergoing thoracoscopic lobectomy under general anesthesia at Taizhou Hospital of Zhejiang Province between October 2017 and May 2018. Patients were randomized to experimental and control groups and were followed for up to 72 hours.

The use of non-invasive ventilation in COVID-19: A systematic review.

Objective: Guidelines from different regions on the use of non-invasive ventilation in COVID-19 have generally been inconsistent. The aim of this systematic review was to appraise the quality and availability of guidelines, and whether non-invasive ventilation in the early stages of the pandemic is of importance.

Design And Method: Databases, including PubMed, Web of Science, and Cochrane Library, as well as websites of international organizations and gray literature, were searched up to June 23, 2020.