Inhibition of USP22 by miR-200b-5p represses gastric cancer cell proliferation and migration by targeting the NF-κB signaling pathway.

Gastric cancer (GC) is an aggressive tumor type with an intricate pathogenesis and limited therapeutic options. Ubiquitin-specific protease 22 (USP22) is a protein implicated in cell proliferation, metastasis, and tumorigenesis. However, the regulatory mechanisms governing USP22 in GC are still not fully understood.

Comprehensive Multidimensional Analysis of Metal(loid)-Containing Dust in Plastic Sports Facilities: Insights into the Potential Sources and Health Risks.

Dust released from widely established plastic sports courts and synthetic turf poses potential environmental and health risks. Herein, we systematically investigate the metal(loid) characteristics, potential sources, and health risks of 162 dust samples from 17 campuses in Beijing, using complementary analytical techniques. Bulk analysis revealed higher levels of Zn, Pb, Cu, Sb, Cd, and Cr than background values, suggesting excessive anthropogenic contamination.

Defining the features and structure of neutralizing antibody targeting the silent face of the SARS-CoV-2 spike N-terminal domain.

Research on virus/receptor interactions has uncovered various mechanisms of antibody-mediated neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, understanding of neutralization by antibodies targeting the silent face, which recognize epitopes on glycan shields, remains limited, and their potential protective efficacy in vivo is not well understood. This study describes a silent face neutralizing antibody, 3711, which targets a non-supersite on the N-terminal domain (NTD) of the spike protein.

Normal weight obesity, circulating biomarkers and risk of breast cancer: a prospective cohort study and meta-analysis.

Background: Individuals with normal weight obesity (NWO) often escape the attention of healthcare providers who may assume that a normal body mass index (BMI) correlates with low health risks. However, it remains unknown whether NWO increases the risk of breast cancer.

Methods: This study included 22,257 and 52,506 pre- and postmenopausal females with normal BMI in the UK Biobank.

Atmospheric Hg(0) dry deposition over environmental surfaces: Insights from mercury isotope fractionation.

Atmospheric Hg(0) dry deposition is a vital process that significantly affects the global distribution and cycling of Hg. However, significant knowledge gaps and challenges remain in understanding atmospheric Hg(0) deposition and its subsequent post-deposition processes. Hg isotope fractionation has emerged as the most powerful tool for evaluating the impact of atmospheric Hg(0) deposition and unraveling key processes associated with it.

Photoelectron-Promoted Sulfate Reduction for Heavy Metal Removal without Organic Carbon Addition.

Sulfate-reducing microorganisms (SRMs) show promise for heavy metal removal from contaminated environments, but their scalability is limited by reliance on organic carbon, sludge formation, and CO emissions. This study investigates using photoelectrons from biogenic (Bio-ZnS) and abiogenic (Abio-ZnS) sphalerite nanoparticles to enhance the activity of G20 (G20) for sulfate reduction and lead removal without organic substrates. Both Abio-ZnS and Bio-ZnS NPs promote sulfate reduction and energy production in G20 cells under illumination without the addition of organic substrates, with Bio-ZnS achieving 1.

Development of Single-Nucleotide Polymorphism (SNP)-Based Species-Specific Real-Time PCR Assays for Authenticating Five Highly Priced Tuna.

Tuna are economically important as food resources in food markets. However, because tuna is often processed into steaks or fillets, the meat can be difficult to identify through morphological features. For effective fishery management and to protect the rights of consumers, it is necessary to develop a molecular method to accurately identify the species used in tuna products.

Droplet-based bioprinting for the tailored fabrication of bacteria-laden living materials.

Droplet-based bioprinting (DBB) allows for high precision, noncontact, and on-demand distribution of bioinks, hence it has been widely utilized in the preparation of bacteria-laden living materials (BLMs). Nonetheless, discontinuous ink deposition makes it challenging to fabricate large-sized intact living structures via this technique. Herein, we explore the way of using DBB to construct centimeter-scale BLMs with bespoke geometries, and further demonstrate its potential applicability in sensing-responsive device by integrating engineered bacteria.

Engineering Topological and Chemical Disorder in Pd Sites for Record-Breaking Formic Acid Electrocatalytic Oxidation.

Designing palladium-based formic acid oxidation reaction (FAOR) catalysts to achieve significant breakthroughs in catalytic activity, pathway selectivity, and toxicity resistance is both urgent and challenging. Here, these challenges are addressed by pioneering a novel catalyst design that incorporates both topological and chemical disorder, developing a new class of PdCuLaYMnW high-entropy amorphous alloys with a porous network (Net-Pd-HEAA) as a highly active, selective, and stable FAOR electrocatalyst. This novel Net-Pd-HEAA demonstrates record-breaking FAOR performance, achieving the mass and specific activities of 5.

Fire-Induced Multiple Changes in Electron Transfer Properties of Peat Soil Organic Matter: The Role of Functional Groups, Graphitic Carbon, and Iron.

Peatland fires induced changes in electron transfer properties and relevant electroactive structures of peat soil organic matter (PSOM) remain ambiguous, impeding comprehension of postfire biogeochemical processes. Here, we revealed temperature-dependent electron exchange capacity (EEC) of PSOM dynamics through simulated peat soil burning (150-500 °C), which extremely changed postfire microbial Fe-nanoparticles reduction and methanogenesis. EEC diminished significantly (60-75% loss) due to phenolic-quinone moieties depletion with increasing temperature, regardless of oxygen availability.

Lipid nanoparticles as adjuvant of norovirus VLP vaccine augment cellular and humoral immune responses in a TLR9- and type I IFN-dependent pathway.

Norovirus (NoV) virus-like particles (VLPs) adjuvanted with aluminum hydroxide (Alum) are common vaccine candidates in clinical studies. Alum adjuvants usually inefficiently assist recombinant proteins to induce cellular immune responses. Thus, novel adjuvants are required to develop NoV vaccines that could induce both efficient humoral and robust cellular immune responses.

A structural snapshot of the multiple working states of the Mpox virus helicase-primase D5.

The Mpox virus (or Monkeypox virus, MPXV) uses its own encoded proteins to form a replication machine that replicates the viral genome in the host cell cytoplasm, making this machinery a key target for antiviral drug design. The D5 (also known as the OPG117 or E5) protein, a bi-functional helicase-primase enzyme, is crucial in the MPXV replication machinery and genome uncoating process. Recently, cryo-electron microscopy (cryo-EM) structures of D5 in multiple states have been determined.

Direct regeneration of LiFePO cathode by inherent impurities in spent lithium-ion batteries.

The direct regeneration method, recognized for its cost-effectiveness, has garnered considerable attentions in the field of battery recycling. In this study, a novel direct regeneration strategy is proposed to repair spent LiFePO (S-LFP) cathodes without the need for impurity removal. Instead, the residual conductive carbon and polyvinylidene fluoride (PVDF) in S-LFP are employed as inherent reductive agents.

Association between serum branched chain amino acids, mammalian target of rapamycin levels and the risk of gestational diabetes mellitus: a 1:1 matched case control study.

Background: To investigate the association between serum branched chain amino acids (BCAAs), mammalian target of rapamycin (mTOR) levels and the risk of gestational diabetes mellitus (GDM) in pregnant women.

Methods: 1:1 matched case-control study was conducted including 66 GDM patients and 66 matched healthy pregnant women (± 3 years) in 2019, in China. Fasting bloods of pregnant women were collected in pregnancy at 24 ~ 28 weeks gestation.

Water-extractable metals as indicators of wheat metal accumulation: Insights from Cd, Pb, Mn, Cu, and Zn.

There is a long-standing debate over the effectiveness of chemical extraction methods in assessing soil metal phytoavailability. This study addresses the limitations of widely-used chemical extraction methods and presents the water-extractable pool as a more reliable indicator based on wheat pot experiments using homogenized agricultural soil amended with lime materials, phosphate, and biochar. Over 120 days' pot experiments, Cd accumulation in whole wheat plants and tissues exhibited positive relationships with water-extractable Cd concentrations at heading and maturity stage (Spearman's rho: 0.

Breastfeeding in infancy and cardiovascular disease in middle-aged and older adulthood: a prospective study of 0.36 million UK Biobank participants.

Background: Cardiovascular disease originates in early life. We aimed to investigate the association between breastfeeding in infancy and cardiovascular disease in adult life.

Methods: We followed 364,240 participants from UK Biobank aged 40-73 years from 2006 - 2010 to 2021.

Enhancing aqueous zinc-ion energy storage performance with ion-mediating carbon quantum dots-modified separators regulating zinc deposition behavior.

Aqueous zinc-ion batteries (AZIBs) hold promising applications owing to their safety, cost-effectiveness, and competitive capacity. However, issues such as zinc dendritic formation and side reactions severely impede their practical viability. Utilizing carbon quantum dots (CQDs) to modify cheap, tenacious, and highly hydrophilic filter paper (FP) as separator effectively improves the electrochemical performance of zinc ion energy storage systems.

Potential improvement in the mechanical performance and thermal resistance of geopolymer with appropriate microplastic incorporation: A sustainable solution for recycling and reusing microplastics.

The accumulation of microplastics (MPs) has been a major threat to the natural environment and human health. However, incineration and landfilling may not be appropriate for the management of MPs. This paper evaluated the feasibility of incorporating MPs with diverse dimensions (50 to 500 μm) and contents (2.

The relationship research between restorative perception, local attachment and environmental responsible behavior of urban park recreationists.

The environmentally responsible behavior of tourists has been one of the focal points in the field of sustainable tourism research in recent years. Taking Guangzhou City Park as an example, this study investigates the relationship between restorative perception, place attachment, and environmentally responsible behavior of urban park recreationists by constructing the theoretical framework of "cognition-emotion-behavior" of recreationalists via online questionnaire surveys and using the test method of structural equation mode. Studies have shown that: (1) When the restorative perception of the environment is compatible, malleable, and attractive, the recreationist will produce environmentally responsible behavior.

Towards a better understanding of ethylmercury in the environment: Addressing propylation derivatization artifact and verifying its occurrence in Chinese wetlands.

Ethylmercury (EtHg), similar to methylmercury (MeHg), is highly neurotoxic and bioaccumulative. Although recent studies suggested its occurrence in natural soils and sediments, the common propylation derivatization for EtHg analysis might generate EtHg artifacts, potentially leading to its overestimation in environmental samples. Furthermore, the extensive environmental prevalence of EtHg remains unverified, keeping its importance largely uncertain.

An insoluble cellulose nanofiber with robust expansion capacity protects against obesity.

An imbalance between energy intake and energy expenditure predisposes obesity and its related metabolic diseases. Soluble dietary fiber has been shown to improve metabolic homeostasis mainly via microbiota reshaping. However, the application and metabolic effects of insoluble fiber are less understood.