Serum Pharmacology Combining Network Pharmacology to Discover the Mechanism of Total Flavonoids in Aronia Melanocarpa Fruit for Acute Lung Injury.

This comprehensive evaluation evaluates the activity of total flavonoids from Atractylodes macrocephala (AMF) in treating acute lung injury (ALI) and explores the mechanism of action of AMF total flavonoids in treating ALI. Method: UV spectrophotometry was used to determine the in vitro antioxidant activity of total flavonoids in AMF; Establishment of ALI model mice induced by lipopolysaccharide (LPS); Analysis of total flavonoid composition and blood migration components in AMF based on UHPLC-MS/MS technology; Analyze the active compounds, targets, and mechanisms of action of AMF total flavonoids in treating ALI through serum drug chemistry combined with network pharmacology. The results of in vitro antioxidant combined with in vivo anti-inflammatory experiments showed that AMF total flavonoids exhibited excellent therapeutic effects on ALI.

Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge.

Transforming Growth Factor-beta () plays a core role in the process of pulmonary fibrosis (PF). The progression of pulmonary fibrosis can be alleviated by siRNA-based inhibiting . However, the limitations of naked siRNA lead to the failure of achieving therapeutic effect.

Efficacy and Safety of New Oral Anticoagulants versus Warfarin in the Resolution of Atrial Fibrillation with Left Atrial/Left Atrial Appendage Thrombus: A Systematic Review and Meta-Analysis.

Background: To compare the efficacy and safety of novel oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) in nonvalvular atrial fibrillation (NVAF) patients with left atrial/left atrial thrombosis through a systematic review and meta-analysis.

Methods: The CBM (China Biology Medicine disc), CNKI (China National Knowledge Infrastructure), VIP (Chinese Technology Periodical Database), Wanfang, PubMed, Embase, Cochrane Library, and Web of Science databases were searched for relevant studies from their inception to June 30, 2022.

Results: Twelve articles (eight cohort studies and four randomized controlled trials) involving 982 patients were included.

The impact of environmental literacy on the health level of rural residents: evidence from the mountainous areas of Sichuan, China.

Introduction: Environmental pollution and health issues are hot topics of discussion in modern society. However, there is a lack of research from the perspective of subjective factors such as environmental protection to study the impact of environmental literacy on health, especially in rural areas.

Methods: First, through field research in the mountainous rural areas of Sichuan Province, 396 data points were collected.

Spatiotemporal multi-feature fusion vehicle trajectory anomaly detection for intelligent transportation: An improved method combining autoencoders and dynamic Bayesian networks.

With the continuous development of intelligent transportation systems, traffic safety has become a major societal concern, and vehicle trajectory anomaly detection technology has emerged as a crucial method to ensure safety. However, current technologies face significant challenges in handling spatiotemporal data and multi-feature fusion, including difficulties in big data processing, and have room for improvement in these areas. To address these issues, this paper proposes a novel method that combines autoencoders, Mahalanobis distance, and dynamic Bayesian networks for anomaly detection.

Fucoxanthin ameliorates ulcerative colitis by maintaining the epithelial barrier via blocking JAK2/STAT3 signaling pathway.

Background: The clinical efficacies of Ulcerative colitis (UC) are far from satisfactory. Fucoxanthin (FUC) is a marine carotenoid that is abundant in seaweed and microalgae. It has been reported that FUC can possess anti-inflammatory and antioxidant.

Entropy-Stabilized Multication Fluorides as a Conversion-Type Cathode for Li-Ion Batteries-Impact of Element Selection.

Metal fluorides (e.g., FeF and FeF) have received attention as conversion-type cathode materials for Li-ion batteries due to their higher theoretical capacity compared to that of common intercalation materials.

Sleep disorders are closely associated with coronary heart disease in US adults (≥20 years): A cross-sectional study.

The purpose of this research was to assess the association between sleep disorders and coronary heart disease (CHD) using data from the National Health and Nutrition Examination Survey (NHANES) database. This cross-sectional study included 9886 eligible participants with valid data on sleep disorders and CHD from the NHANES from 2011 to 2014. The complex NHANES sampling led to use of sample weights in analyses.

Chloroplast ATP synthase restricts photosynthesis under fluctuating light in tomato but not in maize.

Photosynthesis in fluctuating light requires coordinated adjustments of diffusion conductance and biochemical capacity, but the role of chloroplast ATP synthase activity (g) in dynamic photosynthesis is not well understood. In this study, we measured gas exchange, chlorophyll fluorescence and electrochromic shift signals in fluctuating light for leaves of tomato (Solanum lycopersicum) and maize (Zea mays). During the transition from sun to shade, simultaneous increases in g, effective quantum yield of PSII, and net CO assimilation rate (A) occurred in tomato but uncoupled in maize, indicating that g  limited A during the sun-to-shade transition in tomato but not in maize.

Comparison of Cytomegalovirus Reactivation in Children After Allogeneic Hematopoietic Cell Transplantation in 2 Transplant Eras.

Background: Reactivation of cytomegalovirus (CMV) is typically considered harmless as long as the immune system remains unaffected by medications or other factors. CMV reactivation may occur as a result of acute graft-versus-host disease of Grades II to IV. One possible factor contributing to this risk is the rise in the number of donors who lack genetic similarities or relationships.

CaWRKY22b Plays a Positive Role in the Regulation of Pepper Resistance to in a Manner Associated with Jasmonic Acid Signaling.

As important transcription factors, WRKYs play a vital role in the defense response of plants against the invasion of multiple pathogens. Though some WRKY members have been reported to participate in pepper immunity in response to infection, the functions of the majority of WRKY members are still unknown. Herein, was cloned from the pepper genome and its function against was analyzed.

Oxysophoridine inhibits oxidative stress and inflammation in hepatic fibrosis via regulating Nrf2 and NF-κB pathways.

Background: Hepatic fibrosis (HF) runs through multiple stages of liver diseases and promotes these diseases progression. Oxysophoridine (OSR), derived from Sophora alopecuroides l., is a bioactive alkaloid that has been reported to antagonize alcoholic hepatic injury.

OsO as the Contrast-Generating Chemical Species of Osmium-Stained Biological Tissues in Electron Microscopy.

Electron imaging of biological samples stained with heavy metals has enabled visualization of subcellular structures critical in chemical-, structural-, and neuro-biology. In particular, osmium tetroxide (OsO) has been widely adopted for selective lipid imaging. Despite the ubiquity of its use, the osmium speciation in lipid membranes and the process for contrast generation in electron microscopy (EM) have continued to be open questions, limiting efforts to improve staining protocols and therefore high-resolution nanoscale imaging of biological samples.

Technical note: A GPU-based shared Monte Carlo method for fast photon transport in multi-energy x-ray exposures.

Background: The Monte Carlo (MC) method is an accurate technique for particle transport calculation due to the precise modeling of physical interactions. Nevertheless, the MC method still suffers from the problem of expensive computational cost, even with graphics processing unit (GPU) acceleration. Our previous works have investigated the acceleration strategies of photon transport simulation for single-energy CT.

Melatonin enhances resistance to Botryosphaeria dothidea in pear by promoting jasmonic acid and phlorizin biosynthesis.

Ring rot, caused by Botryosphaeria dothidea, is an important fungal disease of pear fruit during postharvest storage. Melatonin, as a plant growth regulator, plays an important role in enhancing the stress resistance of pear fruits. It enhances the resistance of pear fruits to ring rot by enhancing their antioxidant capacity.

An efficient lipid droplet-targeted fluorescent probe for detection of intracellular viscosity.

Lipid droplet, an intracellular lipid reservoir, is vital for energy metabolism and signal transmission in cells. The viscosity directly affects the metabolism of lipid droplets, and the abnormal viscosity is associated with the occurrence and development of various diseases. Therefore, it is indispensable to develop techniques that can detect viscosity changes in intracellular lipid droplets.

Fluctuating light induces a significant photoinhibition of photosystem I in maize.

In nature, light intensity usually fluctuates and a sudden shade-sun transition can induce photodamage to photosystem I (PSI) in many angiosperms. Photosynthetic regulation in fluctuating light (FL) has been studied extensively in C plants; however, little is known about how C plants cope FL to prevent PSI photoinhibition. We here compared photosynthetic responses to FL between maize (Zea mays, C) and tomato (Solanum lycopersicum, C) grown under full sunlight.

Combining pathological and cognitive tests scores: A novel data analytics process to improve dementia prediction models1.

Background: The term 'dementia' covers a range of progressive brain diseases from which many elderly people suffer. Traditional cognitive and pathological tests are currently used to detect dementia, however, applications using Artificial Intelligence (AI) methods have recently shown improved results from improved detection accuracy and efficiency.

Objective: This research paper investigates the efficacy of one type of data analytics called supervised learning to detect Alzheimer's disease (AD) - a common dementia condition.

Effect of Antisolvent Additives in Aqueous Zinc Sulfate Electrolytes for Zinc Metal Anodes: The Case of Acetonitrile.

Aqueous zinc-ion batteries (ZIBs) employing zinc metal anodes are gaining traction as batteries for moderate to long duration energy storage at scale. However, corrosion of the zinc metal anode through reaction with water limits battery efficiency. Much research in the past few years has focused on additives that decrease hydrogen evolution, but the precise mechanisms by which this takes place are often understudied and remain unclear.