Generation of 3D finite element mesh of layered geological bodies in intersecting fault zones.

As the geological fault surface divides the 3D space of stratified ores and rocks into complex spatial surface domains, it is necessary to fully consider the spatial relationship between intersecting fault zones and geological bodies in the process of 3D modeling, and how to accurately establish the 3D finite element mesh of geological bodies in intersecting fault zones is a difficult point in modeling complex geological structure. The laminated geological body in intersecting fault zone is a multifaceted domain grid model consisting of a ground-level grid, a geological fault plane grid, and a range grid. By analyzing the spatial relationship between the geological interfaces of the intersecting fault zones, a closed manifold processing method is proposed to establish the closed manifold spatial surface model of the intersecting fault zones, based on which the closed spatial surface model is tetrahedrally divided to establish a 3D solid model.

Calculation of blast hole charge amount based on three-dimensional solid model of blasting rock mass.

The development and use of intelligent drilling rigs make it available to obtain accurate lithology data of blast drilling. In order to make full use of drilling data to improve blasting efficiency, the following research was carried out. First, a database is established to manage and store the blast hole data recognized by the intelligent drill.

Design method of blasthole charge structure based on lithology distribution.

The density of geological exploration boreholes is one of the main bases for blasthole charge structure design. Due to the low density of geological exploration boreholes, it is impossible to obtain the blast hole rock formations' distribution accurately. With the development and application of intelligent drilling rigs, the lithology distribution data of the blasthole can be accurately obtained, and a blasthole charge structure design method based on the lithology distribution is proposed.

Uterine micro-environment and estrogen-dependent regulation of osteopontin expression in mouse blastocyst.

Embryo implantation is a highly synchronized bioprocess between an activated blastocyst and a receptive uterus. In mice, successful implantation relies on the dynamic interplay of estrogen and progesterone; however, the key mediators downstream of these hormones that act on blastocyst competency and endometrium receptivity acquisition are largely unknown. In this study, we showed that the expression of osteopontin (OPN) in mouse blastocysts is regulated by ovarian estrogen and uterine micro-environment.

Regulation of the ischemia-induced autophagy-lysosome processes by nitrosative stress in endothelial cells.

The cellular mechanisms that underlie the diverse nitrosative stress-mediated cellular events associated with ischemic complications in endothelial cells are not yet clear. To characterize whether autophagic elements are associated with the nitrosative stress that causes endothelial damage after ischemia injury, an in vitro sustained oxygen-glucose deprivation (OGD) and an in vivo microsphere embolism model were used in the present study. Consistent with OGD-induced peroxynitrite formation, a rapid induction of microtubule-associated protein 1 light chain 3 (LC3)-I/II conversion and green fluorescent protein-LC3 puncta accumulation were observed in endothelial cells.

Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.

Peroxynitrite contributes to diverse cellular stresses in the pathogenesis of ischemic complications. Here, we investigate the downstream effector signaling elements of nitrosative stress which regulate ischemia-like cell death in endothelial cells and protective effect of melatonin. When the mitochondrial membrane potential (ΔΨm) of oxygen-glucose deprivation (OGD)-treated cells was assessed using the fluorescent probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazol -carbocyanine iodide, we observed spontaneous changes in peroxynitrite formation.

[A study on shifts of cerebral autoregualtion following end-tidal CO2 by critical closing pressure].

Objective: To investigate the shifts of cerebral autoregulation following end-tidal CO2, and set up a new clinical way to evaluate the lower limit of cerebral autoregulation.

Methods: The cerebral blood flow spectrum of middle cerebral artery, radial blood pressure and end-tidal CO2 (ETco(2)) were simultaneously monitored among 70 healthy volunteers, 38 males and 41 females, aged 21-77. The Lower limit of cerebral autoregulation (LLCA) was determined by critical closing pressure (CCP).