Two new glycosides and a new flavone from .

Three new compounds, including two glycosides, named gerbelavinsides E/G (/), and a flavone, named gerbelavin G (), were isolated from 50% ethanol extract of . Their structures were elucidated based on HR-ESI-MS, IR, UV and NMR spectral data, and the absolute configurations of and were determined by ECD spectra. Three compounds were tested for their inhibition effect against LPS-induced NO production in RAW 264.

Biomechanism of abnormal stress on promoting osteoarthritis of temporomandibular joint through Piezo1 ion channel.

Objective: This study aimed to investigate whether flow fluid shear stress (FFSS)-mediated signal transduction affects the function of Piezo1 ion channel in chondrocyte and to further explore the role of mechanical overloading in development of temporomandibular joint osteoarthritis (TMJ OA).

Methods: Immunohistochemical staining was used to determine the expression of Piezo1 in TMJ OA tissue collected from rat unilateral anterior crossbite (UAC) models. Chondrocytes harvested from normal adult SD rats were treated with FFSS (0, 4, 8, 12 dyn/cm) in vitro.

[Mechanism of total glucosides of White Paeony Capsules in ameliorating acute lung injury based on NLRP3 inflammasome].

This study deciphered the ameliorating effect and molecular mechanism of the total glucosides of White Paeony Capsules(TGP) in the treatment of mice model with acute lung injury(ALI) via NOD-like receptor thermal protein domain associated protein 3(NLRP3) signaling pathway of the inflammasome. The study established an inflammasome activation model of primed bone marrow-derived macrophages(BMDMs), and its molecular mechanism was investigated by Western blot(WB), immunofluorescence staining, enzyme-linked immunosorbent assay(ELISA), and flow cytometry. C57BL/6J mice were randomly divided into a blank control group, a TGP group, a model group(LPS group), LPS+low-and high-dose TGP groups, LPS+MCC950 group, and LPS+MCC950+TGP group, with eight mice per group.

The Pyroptosis-Related Risk Genes APOBEC3D, TNFRSF14, and RAC2 Were Used to Evaluate Prognosis and as Tumor Suppressor Genes in Breast Cancer.

Background: Pyroptosis is a type of cell death that plays an important role in predicting prognosis and immunoregulation in cancers. However, the pyroptosis-related gene signature for prognosis and immune infiltration prediction has not been studied in breast cancer (BC).

Methods: The Gene Expression Omnibus (GEO) and Cancer Genome Atlas (TCGA) databases were used to obtain the expression and clinical data of genes.

Open total dislocation of ankle joint without fractures: A case report.

Rationale: Open total dislocation of ankle joint is rare and often caused by high-energy injury. The present study describes a patient with open total lateral dislocation of ankle joint without fractures and obtained a satisfactory clinical result following early debridement and irrigation, one-stage repairment of ligaments, and plaster external fixation.

Patient Concerns: The patient, a 45-year-old male, complained of right foot pain with bleeding and limited motion.

The incidence and analysis of ipsilateral occult hernia in patients undergoing hernia repair: a single institution retrospective study of 1066 patients.

Background: Misdiagnosis or failure to intraoperatively detect occult hernia in the inguinal region can lead to the recurrence of postoperative hernia and the appearance of local pain symptoms, which affect the patient's quality of life and make it difficult to reperform hernia repair.

Methods: This study included 1066 inguinal hernia patients who underwent surgical treatment at Shanghai Tongren Hospital between January 2016 and October 2018 to investigate ipsilateral occult hernia epidemiology, to analyze the characteristics of ipsilateral occult hernias with regards to patient age, gender, classification and anatomical site, and to explore the superiority and inferiority of the expert hernia surgeons/ non-expert hernia surgeons group and of operation methods in finding occult inguinal hernias.

Results: The incidence of ipsilateral occult hernia in the surgical population was 8.

A Primary Squamous Cell Carcinoma of the Thyroid Presenting as the Anaplastic Thyroid Carcinoma: A Case Report.

Primary squamous cell carcinoma of the thyroid (PSCCT) is an uncommon malignancy that is difficult to diagnose and differentiate. There is no consensus for the early clinical, radiological, or ultrasonic identification of PSCCT before pathological changes are observed in patients. There is also no suitable treatment due to the absence of a definite diagnosis.

[Logistic regression analysis of risk factors of temporomandibular disorder in undergraduates of Xinjiang Medical University].

Purpose: To investigate the prevalence of temporomandibular disorders (TMD) in undergraduates of Xinjiang Medical University and analyse its possible risk factors.

Methods: A sample of 700 medical students included 244 males and 456 females was selected from Xinjiang Medical University and underwent examination of temporomandibular joint, questionnaire survey. Their average age was 20.

Perfusion Computer Tomography Assessment of the Effect of Angiotensin II On Blood Flow Distribution in Rabbits with Intrarenal VX2 Tumors.

Background/aims: Unlike other organs, which only have one set of capillary network, the renal microvasculature consists of two sets of capillary network series connected by efferent arterioles. Angiotensin II constricts the efferent glomerular artery. Hence, renal tumor blood flow (BF) distribution may be different from tumors in other organs.

Thyroid cancer with concurrent breast tubular cancer: A case report and literature review.

Here one concurrent case of a patient with both thyroid and breast cancers was discussed with a comprehensive literature review. On March 21, 2016, a 42-year-old female patient was admitted into our hospital because of right neck mass and left breast mass for 1 week during a routine health examination. On March 22, the combined procedures of complete resection of right thyroid gland plus isthmus with dissection of lymph nodes in right VI region plus left breast regional lumpectomy were performed under endotracheal anesthesia.

[Research of the Raman Signal De-Noising Method Based on Feature Extraction].

To improve time resolution of the Raman measurement system, we need to adopt short scanning time. In this case, the weak Raman signal with vibrational spectrum of the molecular structure is easily to be buried by the high background noise, which influences the further analysis seriously. So it is necessary to de-noise the raw Raman signals.

[Design of Raman Spectroscopy Rapid Detection System for Synthetic Edible Pigment Based on PERS].

Based on Plasmon-enhanced Raman Spectroscopy (PERS) technology, the detection system for rapid field determination of synthetic edible pigments in food，such as beverage，meat productsand preserves，is presented. The hardware framework of this detection system is mainly composed of double central control chips (ARM and FPGA), a sample pretreatment module (containing a nanoparticle giving device), a laser diode source, and a spectral data acquisitioning module; Besides, the software can run the sample pretreatment module automatically while receiving the Raman spectrogram. To verify its performance in edible synthetic pigments, the rapid detection system was applied to determine carmine, citrine, allure red in three actual samples (i.

[Baseline Correction Algorithm for Raman Spectroscopy Based on Non-Uniform B-Spline].

As one of the necessary steps for data processing of Raman spectroscopy, baseline correction is commonly used to eliminate the interference of fluorescence spectra. The traditional baseline correction algorithm based on polynomial fitting is simple and easy to implement, but its flexibility is poor due to the uncertain fitting order. In this paper, instead of using polynomial fitting, non-uniform B-spline is proposed to overcome the shortcomings of the traditional method.

A Method to Improve Electron Density Measurement of Cone-Beam CT Using Dual Energy Technique.

Purpose: To develop a dual energy imaging method to improve the accuracy of electron density measurement with a cone-beam CT (CBCT) device.

Materials And Methods: The imaging system is the XVI CBCT system on Elekta Synergy linac. Projection data were acquired with the high and low energy X-ray, respectively, to set up a basis material decomposition model.

[Raman Spectroscopy Measurement System of Dual Wavelength Laser Module].

Fluorescence interference is one of common interference factors during detection of Raman spectroscopy, while shifted-excitation Raman difference spectroscopy (SERDS) is an effective detection means to reject it. SERDS excites the test substance by two laser with different wavelengths, then difference the obtained Raman spectroscopies. SERDS can eliminate the fluorescence interference effectively, because the fluorescence backgrounds of the two spectroscopies are the same while the Raman peaks are translated.

Network-based Phenome-Genome Association Prediction by Bi-Random Walk.

Motivation: The availability of ontologies and systematic documentations of phenotypes and their genetic associations has enabled large-scale network-based global analyses of the association between the complete collection of phenotypes (phenome) and genes. To provide a fundamental understanding of how the network information is relevant to phenotype-gene associations, we analyze the circular bigraphs (CBGs) in OMIM human disease phenotype-gene association network and MGI mouse phentoype-gene association network, and introduce a bi-random walk (BiRW) algorithm to capture the CBG patterns in the networks for unveiling human and mouse phenome-genome association. BiRW performs separate random walk simultaneously on gene interaction network and phenotype similarity network to explore gene paths and phenotype paths in CBGs of different sizes to summarize their associations as predictions.

[Baseline correction method for Raman spectroscopy based on B-spline fitting].

Baseline drift is a widespread phenomenon in modern spectroscopy instrumentation, which would bring a very negative impact to the feature extraction of spectrum signal, and the baseline correction method is an important means to solve the problem, which is also the important part of Raman signal preprocessing. The general principle of baseline drift elimination is using the fitting method to the fit the baseline. The traditional fitting method is polynomial fitting, but this method is prone to over-fitting and under-fitting, and the fitting order is difficult to be determined.

Fractionated stereotactic radiotherapy for small-cell lung cancer patients with brain metastases.

Objective: Patients with small-cell lung cancer (SCLC) are at high risk of developing brain metastases (BM). Fractionated stereotactic radiotherapy (FSRT) alone or combined with whole brain radiation therapy can be used to treat intracranial metastases. This study was aimed to explore FSRT for BM from SCLC.

Molecular mechanism of inhibitory effects of C-phycocyanin combined with all-trans-retinoic acid on the growth of HeLa cells in vitro.

We studied the effects of all-trans-retinoic acid (ATRA), C-phycocyanin (C-PC), or ATRA+C-PC on the growth of cervical cells (HeLa cells), cell cycle distribution, and apoptosis. The anticancer mechanism of the drug combination was revealed. MTT assay was adopted to determine the effects of C-PC and ATRA on the growth of HeLa cells.

[Study of the radiotherapy modality for patients with stage IIb-IIIb cervical stump cancer].

Objective: To investigate the radiotherapy modality progress of stageIIb-IIIb cervical stump cancer.

Methods: The clinical data of 13 patients with stageIIb-IIIb cervical stump cancer undergoing radiotherapy from January 2000 to April 2012 was reviewed. Before 2006, 8 patients received conventional external beam radiotherapy and brachytherapy.

CD59 underlines the antiatherosclerotic effects of C-phycocyanin on mice.

The effects of C-phycocyanin (C-PC) on atherosclerosis and the regulatory effects of CD59 gene on anti-atherosclerotic roles of C-PC were investigated. Apolipoprotein E knockout (ApoE(-/-)) mice were randomly divided into four groups: control group, C-PC treatment group, CD59 transfection group and C-PC+CD59 synergy group. The mice were fed with high-fat-diet and treated with drug intervention at the same time.

Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice.

Background: How to find an effective gene locus resistant to atherosclerosis has become a hotspot of today's medicine. Membrane attack complex (MAC) has proved to be related with the occurrence and development of atherosclerosis. Complement regulatory protein CD59 is a key regulator of complement MAC assembly.

Fractionated stereotactic radiotherapy for 136 patients with locally residual nasopharyngeal carcinoma.

Background: To evaluate the efficacy and toxicity of fractionated stereotactic radiotherapy (FSRT) in patients with residual nasopharyngeal carcinoma (NPC).

Methods: From January 2000 to December 2009, 136 NPC patients with residual lesions after primary radiotherapy (RT) were treated by FSRT. The total dose of primary RT was 68.

[Infrared energy level lifetime measurement system by visible upconversion luminescence detection based on double-pulse injection LD module].

The lifetime of Er3+ and 4I13/2 energy level is of very significance for evaluating the application potential of Er(3+)-doped materials in optical communication. In the present article, based on the Er3+ excited state absorption upconversion (UC) luminescence under 980 nm double-pulse injection LD excitation, the authors detected the red UC luminescence intensity under different time gap between double pulses, then according to the dependence between UC red luminescence intensity and time gap between double pulses, deduced the fitting formula for obtained medial energy level lifetime of Er3+, and actualized the measurement of infrared level lifetime in visible region. So, combining photomultiplier tube (R2658) with double-pulse injection LD module with controllable time gap and synchronous pulse sample, we can obtain all the infrared level lifetime of Er3+, and this is a cost saving lifetime measurement system with micros resolution.