Enhanced force sensitivity based on Duffing nonlinearity in a dissipatively coupled optomechanical system.

The study of force sensitivity based on a cavity optomechanical system plays a prominent role in quantum precision measurement and provides an ideal platform for precision sensing technology. Here, we propose a scheme to enhance the force sensitivity of a dissipatively coupled optomechanical system by inducing Duffing nonlinearity. The numerical analysis shows that inducing Duffing nonlinearity significantly improves the force sensitivity compared to the system without Duffing nonlinearity, even surpassing the standard quantum limit (SQL) by more than five orders of magnitude.

Tumor-suppressive microRNA-497 targets IKKβ to regulate NF-κB signaling pathway in human prostate cancer cells.

Background: Prostate cancer (PCa) is one of the most prevalent malignant tumors, PCa-related death is mainly due to the high probability of metastasis. MicroRNAs (miRNAs) play an important role in cancer initiation, progression and metastasis by regulating their target genes.

Methods: real-time PCR was used to detected the expression of microRNA-497.

Microvesicles derived from human umbilical cord mesenchymal stem cells facilitate tubular epithelial cell dedifferentiation and growth via hepatocyte growth factor induction.

During acute kidney injury (AKI), tubular cell dedifferentiation initiates cell regeneration; hepatocyte growth factor (HGF) is involved in modulating cell dedifferentiation. Mesenchymal stem cell (MSC)-derived microvesicles (MVs) deliver RNA into injured tubular cells and alter their gene expression, thus regenerating these cells. We boldly speculated that MVs might induce HGF synthesis via RNA transfer, thereby facilitating tubular cell dedifferentiation and regeneration.

The regulation of inflammatory mediators in acute kidney injury via exogenous mesenchymal stem cells.

Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity. Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI.

Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.

Several studies suggest that mesenchymal stem cells (MSCs) possess antitumor properties; however, the exact mechanisms remain unclear. Recently, microvesicles (MVs) are considered as a novel avenue intercellular communication, which may be a mediator in MSCs-related antitumor effect. In the present study, we evaluated whether MVs derived from human umbilical cord Wharton's jelly mesenchymal stem cells (hWJMSCs) may inhibit bladder tumor T24 cells growth using cell culture and the BALB/c nu/nu mice xenograft model.

Research on the steroidogenesis of proliferated Leydig cells in vitro.

Several treatments for patients with primary hypogonadism are available, but these are associated with major complications. In this study, we explored the possibility of testosterone secretion by proliferated Leydig cells embedded in Matrigel with the aim of developing a source of endogenous testosterone supplement for recipients while reducing the need for donor material. Leydig cells were isolated and proliferated in vitro.

The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism.

Background Aims: The effects of human Wharton's jelly-derived mesenchymal stromal cells (WJ-MSC) on acute and chronic kidney injury induced by ischemia-reperfusion injury (IRI) were assessed.

Methods: WJ-MSC were injected intravenously immediately after solitary kidney ischemia for 45 min. Cells were labeled with 5-bromo-2'deoxy-uridine (BrdU) for tracing in vivo.

Tubularized urethral replacement using tissue-engineered peritoneum-like tissue in a rabbit model.

Introduction: This study aims to investigate whether mesothelial cells could function as seed cells to construct tissue-engineered peritoneum-like tissue for urethral reconstruction in a rabbit model.

Materials And Methods: Bladder acellular matrices were prepared and trimmed to 1.5 × 1 cm.

Ureteral reconstruction using autologous tubular grafts for the management of ureteral strictures and defects: an experimental study.

Objective: To investigate whether the peritoneal cavity could function as a bioreactor to produce autologous tubular grafts for ureteral reconstruction in beagles.

Materials And Methods: 8-Fr Silastic tubes were implanted into the peritoneal cavities of 6 female beagles. At 3 weeks, the tubes were harvested and the tubular tissue covering the tubes was gently everted.

Laparoscopic radical excision of urachal remnants with recurrent infection in infants.

Purpose: To evaluate the usefulness of laparoscopic surgery in the management of urachal remnants with recurrent infection in infants.

Patients And Methods: Eight infants (mean age 9.6 months, range 2-16 months) underwent laparoscopic excision of urachal remnants with recurrent infection between June 2006 and December 2008.

Peritoneal cavity as bioreactor to grow autologous tubular urethral grafts in a rabbit model.

Purpose: To investigate whether peritoneal cavity could function as bioreactor to produce autologous tubular grafts for urethral reconstruction in male rabbits.

Methods: 8Fr silastic tubes were implanted into peritoneal cavities of nine male rabbits. By 2 weeks, tubes were harvested and the tubular tissue covering the tubes was everted.

Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP).

The objective of this study was to first evaluate the developmental abnormalities and carry out the molecular analysis of external genitalia in newborn hypospadiac male rats induced by maternal exposure to di-n-butyl phthalate (DBP). Timed-pregnant rats were given DBP by gastric intubation at dose of 750 mg/kg body weight (bw)/day from gestation day (GD) 14 to GD18 to establish a hypospadiac rat model. The incidence of hypospadias was 46.

Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat.

To investigate the time-dependent effects of acrylamide (ACR) on the antioxidative status in rat nerve tissues, adult male Wistar rats were given ACR (40 mg/kg, i.p., 3 times/week) for 2, 4, 6 and 10 weeks, respectively.

[In vivo and in vitro determination of changes of electrophysiology in rats with allyl chloride poisoning].

Objective: To compare the results of in vivo and in vitro in determination of the changes of allyl chloride (AC)-induced electrophysiology in rats sciatic nerve.

Methods: Ninety male Wistar rats weighted 180 approximately 220 g were divided randomly into two groups, i.e.

Time-dependent changes of lipid peroxidation and antioxidative status in nerve tissues of hens treated with tri-ortho-cresyl phosphate (TOCP).

Tri-ortho-cresyl phosphate (TOCP) could induce a delayed neurodegenerative condition known as organophosphorus easter-induced delayed neurotoxicity (OPIDN) in human beings and sensitive animals. However, the mechanisms of OPIDN remain unknown. This study investigated the time-dependent changes of the lipid peroxidation (malondialdehyde, MDA) and antioxidative status (glutathione, GSH; glutathione peroxidase, GSH-Px; glutathione reductase, GR; superoxide dismutase, SOD and anti-reactive oxygen species, anti-ROS) in nerve tissues for elucidating the mechanism of OPIDN induced by TOCP.

[Time dependent changes in antioxidation of rat serums and sciatic nerves caused by toxicology].

Objective: To study the time dependent antioxidation changes of serum and sciatic nerve in rats intoxicated with acrylamide.

Methods: Male Wistar rats weighing 180 to 220 g were given acrylamide dissolved in physiological saline (40 mg/kg ip 3 days/week). The control groups received normal saline.

[Clinical significance of prostatic-specific antigen levels in patients with benign prostatic hyperplasia complicated by low urinary tract syndrome].

Objective: To evaluate the clinical significance of prostatic-specific antigen (PSA) levels in patients with benign prostatic hyperplasia (BPH) complicated by low urinary tract syndrome( LUTS).

Methods: The levels of tPSA, fPSA and fPSA/tPSA ratio were detected and compared in 520 cases of BPH with LUTS and 196 cases without LUTS.

Results: The mean levels of tPSA in the cases of BPH with LUTS and without LUTS were (5.

Allyl chloride-induced time dependent changes of lipid peroxidation in rat nerve tissue.

To accurately know the time-dependent changes of the lipid peroxidation and antioxidative status for elucidating the mechanism of neuropathy induced by allyl chloride (AC), the malondialdehyde (MDA), anti-reactive oxygen species (anti-ROS), glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were investigated in cerebrum, spinal cord and sciatic nerve of rats after 0, 3, 6, 9, 12 weeks of AC administration. AC was administrated to Wistar rats by gavage at a single dosage of 200 mg/kg/per dose (three times per week). Rats were sacrificed after 0, 3, 6, 9, 12 weeks of treatment, and cerebrum, spinal cord, sciatic nerves were dissected, homogenized and used for the determination of lipid peroxidation and antioxidative status.

[Experience in treating advanced prostate cancer with bladder outlet obstruction].

Background & Objective: The incidence and discovery rate of prostate cancer is increased in recent years; with advanced age and multiple organs dysfunction, the advanced prostate cancer patients have poor quality of life. This study was to explore suitable treatment for these patients.

Methods: A total of 80 advanced prostate cancer patients with bladder outlet obstruction were treated by transurethral electrovaporization of the prostate (TVP), plus castration and antiandrogen therapy.

[Comparison of endoscopic irsection and vaporization for superficial bladder cancer].

Objective: To evaluate the method and clinical value of endoscopic surgery by comparing endoscopic resection and vaporization for superficial bladder tumor.

Methods: 396 patients with superficial bladder papillary transitional cell carcinoma were treated by endoscopic therapy. 180 patients (Group A) were treated by transurethral resection of bladder tumor (TURBT) and 216 (Group B) by transurethral vaporization of bladder tumor (TVBT).

[Modified cystectomy with preservation of erectile and ejaculatory functions in men with nonmalignant bladder disease].

Objectives: To evaluate modified cystectomy with preservation of erectile and ejaculatory functions in men with nonmalignant bladder disease.

Methods: Seven cases with average age of 27 years presented with bladder disease necessitating cystectomy, including 2 cases of tuberculous contractile bladder, 1 case of extensive polypoid cystitis glandularis, 4 cases of late stage of neurogenic bladder. All patients wished to maintain erectile and ejaculatory functions after the operation.