APE1 shRNA-loaded cancer stem cell-derived extracellular vesicles reverse Erlotinib resistance in non-small cell lung cancer via the IL-6/STAT3 signalling.

Objective: Apurinic endonuclease 1 (APE1) has been suggested as an oncogene of lung tumours and our bioinformatics analysis identified the association between Erlotinib resistance and interleukin-6 (IL-6). Thus, we performed this work to delineate the mechanistic actions of APE1/IL-6 signalling in Erlotinib resistance of non-small cell lung cancer (NSCLC).

Methods: We selected human NSCLC cell lines HCC827 and PC9 to establish Erlotinib-resistant HCC827R and PC9R cells.

Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling.

Background: Some driver oncogenes are still unknown in non-small-cell lung cancer (NSCLC). DNAJC19, a major component of the translocation machinery of mitochondrial membranes, is a disease-associated protein. Herein, we report the role of DNAJC19 in NSCLC cell growth and metastasis.

The effects of the crosslinking position and degree of conjugation in perylene tetraanhydride bisimide microporous polymers on fluorescence sensing performance.

In this study, two fluorescence conjugated microporous polymers based on perylene tetraanhydride bisimide (DPA and DPA) were prepared Sonogashira-Hagihara cross-coupling polymerization for the efficient detection of -nitrophenol (-NP). They were well characterized FT-IR, solid state C NMR, elemental analysis, and other material characterization techniques. The experiments proved that both CMPs possess high thermal and chemical stability and a porous nature with Brunauer-Emmett-Teller (BET) specific surface areas of 41.

Molecular mechanism and role of NF-κB in the early diagnosis of cervical cancer.

Purpose: The purpose of this study was to find out the activity and molecular mechanism of NF-kB subunits in cervical cancer which in turn were used as a molecular marker in diagnosing cancer progression.

Methods: Different cervical cancer biopsies were obtained from patients after obtaining proper written consent and approval, which were subjected to immunohistochemistry. Performed were Western blot analysis and electrophoretic mobility shift assays.

The complete genome of cv. dongzao, an economic crop in Yellow River Delta of China.

The complete chloroplast genome of cv. dongzao, known as an important economic cultivar in Yellow River Delta of China was reported. It exhibits a quadripartite structure with 161,493 bp including a large single copy region (89,178 bp), a small single copy region (19,357 bp) and a pair of inverted repeats regions (26,479 bp).

Gene Expression and Correlation of Pten and Fabp4 in Liver, Muscle, and Adipose Tissues of Type 2 Diabetes Rats.

Background: The aim of this work was to study the Fabp4 and Pten gene expression and correlation in the liver, muscle, and adipose tissues of type 2 diabetes mellitus (T2DM) rats.

Material And Methods: Male Wistar rats (8 weeks old) were randomly divided into 2 groups (n=12/group): a control group fed a normal diet for 8 weeks and an experimental group fed a high-fat, high-sugar diet for 8 weeks and that received 25 mg/kg streptozotocin by intraperitoneal injection to induce T2DM. The random blood glucose, fasting blood glucose, and fasting insulin levels were measured.

MicroRNA-200c and microRNA-141 as potential diagnostic and prognostic biomarkers for ovarian cancer.

Ovarian cancer is the fifth leading cause of female death globally due to its low survival rates. Thus, improved approaches for ovarian cancer detection are urgently needed. MicroRNAs as a new class of biomarkers have been explored in recent studies.

[Shift-share analysis on regional industrial pollution growth].

Based on the statistical calculation of industrial pollution charge, an extended shift share analysis method was employed to study the regional industrial pollution growth in Jilin Province, and the preferred action for regional industrial ecological transition was discussed from a view point of pollution treatment. The results could be summarized as follows: 1) Proportional shift could suggest some ways to promote industrial ecological transition from the aspect of industrial organization, while differential shift can provide some enlightenment for pollution treatment in terms of technology. The variation coefficients of proportional shift and differential shift at regional scale are 15.

[Prognosis of metabolic syndrome in coronary artery disease patients of different genders].

Objective: To analyze the prevalence and characteristics of metabolic syndrome (MS) in the patients with coronary artery disease (CAD) of different genders who underwent revascularization.

Methods: The clinical data of 2596 patients in the DESIRE (Drug-eluting Stent Impact on Revascularization) study who underwent percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) were analyzed and the patients were followed up till death. MS was diagnosed based on the Chinese standard (modified ATP III).

A novel fluorescent array for mercury (II) ion in aqueous solution with functionalized cadmium selenide nanoclusters.

Mono-disperse CdSe nanoclusters have been prepared facilely and functionalized with l-cysteine through two steps by using safe and low cost substances. They are water-soluble and biocompatible. Especially these functionalized quantum dots can be stably soluble in water more than for 30 days, and the intensity of fluorescence and absorbance was decreased less than 15% of fresh prepared CdSe colloids.

Facile synthesis of water-soluble and size-homogeneous cadmium selenide nanoparticles and their application as a long-wavelength fluorescent probe for detection of Hg(II) in aqueous solution.

Highly luminescent uncoated water-soluble and mono-disperse CdSe nanoparticles (NPs) have been prepared facilely. Uncoated CdSe core NPs possessing a good size distribution was accompanied with long wavelength of fluorescence emission. It is interesting to note that these functionalized NPs are soluble in water medium stably for more than 1 month, and no significant changes were found in the optical characteristics in comparison with fresh CdSe NPs prepared.

Effect of metabolic syndrome on prognosis and clinical characteristics of revascularization in patients with coronary artery disease.

Background: People with metabolic syndrome are at higher risk for developing coronary artery disease (CAD). The effect of the metabolic syndrome on outcomes in patients with preexisting CAD has not been well studied. This study was conducted to assess the prevalence, characteristics, in hospital and long term prognosis of CAD with metabolic syndrome and to determine the factors influencing the prognosis of the disease.

[Influence of initial admission department for coronary arteriography on choice of mode of coronary revascularization].

Objective: To investigate the influence of initial admission department for coronary arteriography on the choice of mode of coronary revascularization.

Methods: From October 2003 to June 2004 2156 patients with coronary heart disease were admitted into the department of internal medicine (1667 cases) or department of surgery (489 cases) to undergo coronary arteriography (CAG) and coronary revascularization. The influence of the initial admission departments on the choice of mode of coronary revascularization for the patients with different clinical manifestations and angiographic characteristics, including one-vessel disease, two-vessel disease, three-vessel disease, and multi-vessel disease of different types was analyzed.

Preparation of novel mercury-doped silver nanoparticles film glassy carbon electrode and its application for electrochemical biosensor.

A novel mercury-doped silver nanoparticles film glassy carbon (Ag/MFGC) electrode was prepared in this study. Electrochemical behaviors of cysteine on the Ag/MFGC electrode were investigated by electrochemical impedance spectroscopy and cyclic voltammetry (CV). The results indicated that cysteine could be strongly adsorbed on the surface of the Ag/MFGC electrode to form a thin layer.