Publications by authors named "Ying-Yuan Yu"
Article Synopsis
- This study aimed to compare the effectiveness of different biologic drugs for treating psoriasis over a 52-week period in real-world settings, addressing a lack of existing data.
- A total of 386 patients using biologics like ixekizumab, secukinumab, guselkumab, and adalimumab were analyzed, revealing that guselkumab had the highest drug survival rate at 72.2%.
- Findings indicate that improving drug efficacy is essential for enhancing treatment outcomes in psoriasis patients, as the main reasons for stopping treatment were lack of effectiveness and economic burdens.
Background: Psoriasis is a systemic inflammatory disease characterized by epidermal hyperplasia and skin inflammatory infiltrates. Inactivation of AMPK has been shown to decrease autophagy, thereby inhibiting elimination of inflammatory factors and harmful substances, and aggravating psoriasis. However, the molecular mechanism through which AMPK affects psoriasis remains to be further explored.
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