Spatially Confined π-Complexation within Pore-Space-Partitioned Metal-Organic Frameworks for Enhanced Light Hydrocarbon Separation and Purification.

Ultramicroporous metal-organic frameworks (MOFs) are demonstrated to be advantageous for the separation and purification of light hydrocarbons such as CH, CH, and CH. The introduction of transition metal sites with strong π-complexation affinity into MOFs is more effective than other adsorption sites for the selective adsorption of π-electron-rich unsaturated hydrocarbon gases from their mixtures. However, lower coordination numbers make it challenging to produce robust MOFs directly utilizing metal ions with π-coordination activity, such as Cu, Ag, and Pd.

De-Linker-Enabled Exceptional Volumetric Acetylene Storage Capacity and Benchmark C H /C H and C H /CO Separations in Metal-Organic Frameworks.

An ideal adsorbent for separation requires optimizing both storage capacity and selectivity, but maximizing both or achieving a desired balance remain challenging. Herein, a de-linker strategy is proposed to address this issue for metal-organic frameworks (MOFs). Broadly speaking, the de-linker idea targets a class of materials that may be viewed as being intermediate between zeolites and MOFs.

Competitive Coordination-Oriented Monodispersed Ruthenium Sites in Conductive MOF/LDH Hetero-Nanotree Catalysts for Efficient Overall Water Splitting in Alkaline Media.

Rational exploration of efficient, inexpensive, and robust electrocatalysts is critical for the efficient water splitting. Conjugated conductive metal-organic frameworks (cMOFs) with multicomponent layered double hydroxides (LDHs) to construct bifunctional heterostructure catalysts are considered as an efficient but complicated strategy. Here, the fabrication of a cMOF/LDH hetero-nanotree array catalyst (CoNiRu-NT) coupled with monodispersed ruthenium (Ru) sites via a controllable grafted-growth strategy is reported.

Amide-Functionalized Metal-Organic Frameworks Coupled with Open Fe/Sc Sites for Efficient Acetylene Purification.

Acetylene (CH) purification is of great importance for many chemical synthesis and processes. Metal-organic frameworks (MOFs) are widely used for gas adsorption and separation due to their variable structure and porosity. However, the exploitation of ideal MOF adsorbents for CH keeps a challenging task.

Precise Pore Space Partitions Combined with High-Density Hydrogen-Bonding Acceptors within Metal-Organic Frameworks for Highly Efficient Acetylene Storage and Separation.

The high storage capacity versus high selectivity trade-off barrier presents a daunting challenge to practical application as an acetylene (C H ) adsorbent. A structure-performance relationship screening for sixty-two high-performance metal-organic framework adsorbents reveals that a moderate pore size distribution around 5.0-7.

Tuning the Pore Surface of an Ultramicroporous Framework for Enhanced Methane and Acetylene Purification Performance.

Both methane (CH) and acetylene (CH) are important energy source and raw chemicals in many industrial processes. The development of an energy-efficient and environmentally friendly separation and purification strategy for CH and CH is necessary. Ultramicroporous metal-organic framework (MOF) materials have shown great success in the separation and purification of small-molecule gases.

Globally stabilized bent carbon-carbon triple bond by hydrogen-free inorganic-metallic scaffolding AlF.

For over 100 years, known bent C[triple bond, length as m-dash]C compounds have been limited to those with organic (I) and all-carbon (II) scaffoldings. Here, we computationally report a novel type (III) of bent C[triple bond, length as m-dash]C compound, , CAlF-01, which is the energetically global minimum isomer and bears an inorganic-metallic scaffolding and unexpected click reactivity.

Multimetal Incorporation into 2D Conductive Metal-Organic Framework Nanowires Enabling Excellent Electrocatalytic Oxidation of Benzylamine to Benzonitrile.

As an important organic intermediate, benzonitrile (BN) is widely involved in organic synthetic chemistry and pharmaceutical and dyestuff industries. However, the exploration of a more efficient and controllable synthesis technique and the corresponding greener catalysts for the synthesis of BN still poses a great challenge. Herein, with multimetallic two-dimensional conductive metal-organic frameworks (2D cMOF) as anodic electrocatalysts, we develop a green, convenient, and highly efficient electrochemical synthesis strategy for BN.

Systematic Regulation of CH/CO Separation by 3p-Block Open Metal Sites in a Robust Metal-Organic Framework Platform.

The separation of a mixture of CH and CO is a great challenge due to their similar molecular sizes and shapes. Al-based metal-organic frameworks (Al-MOFs) have great promise for gas separation applications due to their light weight, high stability, and low cost. However, the cultivation of suitable Al-MOF single crystals is extremely difficult and has limited their explorations up to now.

Mimic of Ferroalloy To Develop a Bifunctional Fe-Organic Framework Platform for Enhanced Gas Sorption and Efficient Oxygen Evolution Electrocatalysis.

It is well-known that the formation of ferroalloy with the addition of the second or third metal during the steel-making process usually can improve the performance of the iron. Inspired by ferroalloy materials, it is speculated that the pore environment, framework charge, and catalytic properties of metal-organic frameworks (MOFs) could be optimized dramatically via the introduction of ferroalloy-like inorganic building blocks. However, different to ferroalloy, the accurate integration of different metals into one MOF platform is still challenging.

Lignans and phenylpropanoids from the liquid juice of .

Seven lignans and eight phenylpropanoids, including one new lignan, 7,8,8'-5,5'-dimethoxyariciresinol-4----glucopyranoside (), were isolated from the liquid juice of . Their structures were established by extensive spectroscopic analyses. The absolute configuration of the new compound was determined by comparing its experimental electronic circular dichroism (ECD) spectra with calculated ECD spectra.

Ultramicroporous Building Units as a Path to Bi-microporous Metal-Organic Frameworks with High Acetylene Storage and Separation Performance.

A strategy called ultramicroporous building unit (UBU) is introduced. It allows the creation of hierarchical bi-porous features that work in tandem to enhance gas uptake capacity and separation. Smaller pores from UBUs promote selectivity, while larger inter-UBU packing pores increase uptake capacity.

New global minima of 6-vertex dicarboranes: classical but unexpected.

Dicarboranes generally adopt global minimum predicted by the well-known Wade-Mingos rules, although one classical non-closo structure in the benzvalene form has long been pursued and later synthesized. Here we predicted two new non-closo global minima for 6-vertex dicarboranes (C2B4R6), i.e.

CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection.

Despite current immunosuppressive strategies, long-term lung transplant outcomes remain poor due to rapid allogenic responses. Using a stringent mouse model of allo-airway transplantation, we identify the CCR4-ligand axis as a central node driving secondary lymphoid tissue homing and activation of the allogeneic T cells that prevent long-term allograft survival. CCR4 deficiency on transplant recipient T cells diminishes allograft injury and when combined with CTLA4-Ig leads to an unprecedented long-term lung allograft accommodation.

Comparative Effects of Monosialoganglioside versus Citicoline on Apoptotic Factor, Neurological Function and Oxidative Stress in Newborns with Hypoxic-Ischemic Encephalopathy.

Objective: To determine the comparative effect of monosialoganglioside versus citicoline on the content changes of serum apoptotic factors (PDCD5, sFas and sFasL), neurological function indices (BDNF, NSE, S100-β and NGF) and oxidative stress indices (SOD, MDA and GSH-PX) in newborns with hypoxic-ischemic encephalopathy (HIE).

Study Design: An experimental study.

Place And Duration Of Study: Emergency Department, Affiliated Children's Hospital of Zhengzhou University, China, from October 2016 to February 2018.

The Impact of Allograft CXCL9 during Respiratory Infection on the Risk of Chronic Lung Allograft Dysfunction.

Background: The long term clinical significance of respiratory infections after lung transplantation remains uncertain.

Methods: In this retrospective single-center cohort study of 441 lung transplant recipients, we formally evaluate the association between respiratory infection and chronic lung allograft dysfunction (CLAD). We furthermore hypothesized that bronchoalveolar lavage fluid (BALF) CXCL9 concentrations are augmented during respiratory infections, and that episodes of infection with elevated BALF CXCL9 are associated with greater CLAD risk.

Ionothermal synthesis of novel Pb-OH-Cu-X (X = Cl, Br and I) quaternary heterometallic frameworks with tunable optical properties.

Reported herein is the new application of ionothermal synthesis for inorganic optical materials. Under ionothermal conditions with different imidazolium ionic liquids, novel quaternary heterometallic frameworks based on [Pb(OH)] cubane and [CuCl] or [CuBr] chains and [CuI] binuclear clusters have been successfully produced. Simple chlorine, bromine and iodine replacement leads to not only the space group change (tetragonal I41/acd for 1 and 2, and orthorhombic Fddd for 3) but also the topological net transformation (8,12-net for 1 and 2, and 6,6-net for 3).

Theoretical Prediction on [5]Radialene Sandwich Complexes (CpM)(CH) (Cp = η-CH; M = Fe, Co, Ni): Geometry, Spin States, and Bonding.

[5]Radialene, the missing link for synthesis of radialene family, has been finally obtained via the preparation and decomplexation of the [5]radialene-bis-Fe(CO) complex. The stability of [5]radialene complex benefits from the coordination with Fe(CO) by losing free 1,3-butadiene structures to avoid polymerization. In light of the similar coordination ability of half-sandwiches CpM(Cp = η-CH; M = Fe, Co, Ni), there is a great possibility that the sandwiched complexes of [5]radialene with CpM are available.

CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis.

Idiopathic pulmonary fibrosis is a fatal lung disease with a median survival of 2 to 5 years. A decade of studies has downplayed inflammation contributing to its pathogenesis. However, these studies preceded the discovery of regulatory T cells (Tregs) and all of their functions.

Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model.

Intrauterine growth restriction (IUGR) increases the risk of respiratory compromise throughout postnatal life. However, the molecular mechanism(s) underlying the respiratory compromise in offspring following IUGR is not known. We hypothesized that IUGR following maternal food restriction (MFR) would affect extracellular matrix deposition in the lung, explaining the long-term impairment in pulmonary function in the IUGR offspring.

Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis.

Background: Pulmonary sarcoidosis involves an intense leukocyte infiltration of the lung with the formation of non-necrotizing granulomas. CC chemokines (chemokine (C-C motif) ligand 2 (CCL2)-CCL5) are chemoattractants of mononuclear cells and act through seven transmembrane G-coupled receptors. Previous studies have demonstrated conflicting results with regard to the associations of these chemokines with sarcoidosis.

IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome.

Acute allograft rejection is considered to be a predominately type 1 immune mediated response to the donor alloantigen. However, the type 2 immune mediated response has been implicated in multiple fibroproliferative diseases. Based on the fibro-obliterative lesion found during bronchiolitis obliterans syndrome (BOS), we hypothesized that the type 2 immune mediated response is involved in chronic lung allograft rejection.