Publications by authors named "Ying-Yi Chang"

An integrated optical chip that minimizes the size of the energy-tuning single-resonance-mode x-ray monochromator system into a 3×5 silicon wafer is proposed. A Fabry-Perot x-ray resonator and two back-reflecting Si mirrors are employed on the wafer as the optical components, where Si(12 4 0) back reflection is used for both Fabry-Perot resonance and re-diffraction of the x-ray beams from the resonator in the incident direction. We can achieve an energy bandwidth of 3.

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Bismuth telluride (BiTe)-based thermoelectric materials are well-known for their high figure-of-merit ( value) in the low-temperature region. Stable joints in the module are essential for creating a reliable device for long-term applications. This study used electroless Co-P to prevent a severe interfacial reaction between the joints of solder and BiTe.

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The covalent electron density, which makes Si(222) measurable, is subject to laser excitation. The three-wave Si(222)/(13 {\overline 1}) diffraction at 7.82 keV is used for phase measurements.

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An X-ray interference-monochromator combining a Fabry-Perot resonator (FPR) and a double-crystal monochromator (DCM) is proposed and realized for obtaining single-mode X-rays with 3.45 meV energy resolution. The monochromator is based on the generation of cavity interference fringes from a FPR and single-mode selection of the transmission spectrum by a DCM of a nearly backward symmetric reflection geometry.

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Hard X-ray Fabry-Perot resonators (FPRs) made from sapphire crystals were constructed and characterized. The FPRs consisted of two crystal plates, part of a monolithic crystal structure of Al2O3, acting as a pair of mirrors, for the backward reflection (0 0 0 30) of hard X-rays at 14.3147 keV.

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Single-mode selection is realized for hard x-ray cavity resonance using a three-mirror crystal device. The developed device consists of two coupled Si Fabry-Perot resonators (FPRs) and uses (12 4 0) backward diffraction to reflect back and forth the incident 14.4388 keV x-ray beam.

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Malignant immature ovarian teratomas (IOTs) most often occur in women of reproductive age. It is unclear, however, what roles estrogenic signaling plays in the development of IOT. In this study, we examined whether estrogen receptors (ERα and β) promote the cellular malignancy of IOT.

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Endometrial cancer (EMC) is a sex steroid hormone-related female malignancy. Androgen and androgen receptor (androgen/AR) signals have been implicated in EMC progression. Cancer stem/progenitor cells (CSPCs) are suspected to link to chemoresistance in patients with EMC.

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Introduction: Resistance of cancer stem/progenitor cells (CSPCs) to chemotherapy can lead to cancer relapse. Ovarian teratocarcinoma (OVTC) arises from germ cells and comprises pluripotent cells that can be used to study cancer cell stemness. In this study, we evaluated whether microRNA-21 (miR-21) promotes ovarian teratocarcinoma by maintaining cancer stem/progenitor populations.

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Synopsis of recent research by authors named "Ying-Yi Chang"

  • Ying-Yi Chang's research predominantly focuses on advanced optical technologies and their applications in both x-ray systems and cancer biology, indicating a multidisciplinary approach that bridges physics and biological sciences.
  • Recent studies include the design of integrated optical chips for high-resolution x-ray monochromators, and investigations into interfacial stability in thermoelectric materials, highlighting a commitment to innovation in material science and engineering.
  • Furthermore, Chang's work also explores the molecular mechanisms in cancer, particularly regarding the role of estrogen and microRNA in malignancies, signifying an interest in cancer stem cell dynamics and therapeutic resistance.