Publications by authors named "Ying-Xin Zhao"

Four cobalt-based metal-organic frameworks (Co-MOFs) based on different ligands with varying electron-donating properties (dpt = 2,5-di(pyridin-4-yl)-1,3,4-thiadiazole, NH₂bdc = 5-aminoisophthalic acid, OHbdc = 5-hydroxyisophthalic acid, H₂tdc = thiophene-2,5-dicarboxylic acid, and hfipbb = 4,4'-(hexafluoropropane-2,2-diyl)bisbenzoic acid) are synthesized. Among them, Co-dpt-NH₂bdc demonstrates the highest nitrogen reduction reaction activity, achieving an ammonia (NH) yield of 68.61 µg·h⁻¹·mg⁻¹ and Faraday efficiency (FE) of 6.

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Three kinds of metal-organic frameworks possessing analogous structures were prepared by regulating the structure units of organic linkers. MOF/nickel foam electrocatalysts were formed by in situ hydrothermal growth of MOFs on a clean supported substrate nickel foam (NF), and the corresponding composites were prepared. We phosphatated them and obtained the heterojunction catalyst.

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Background:  Oral anticoagulation (OAC) following catheter ablation (CA) of nonvalvular atrial fibrillation (NVAF) is essential for the prevention of thrombosis events. Inappropriate application of OACs does not benefit stroke prevention but may be associated with a higher risk of bleeding. Therefore, this study aims to develop clinical data-driven machine learning (ML) methods to predict the risk of thrombosis and bleeding to establish more precise anticoagulation strategies for patients with NVAF.

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  • Cadmium (Cd) is a toxic metal that can accumulate in the food chain, causing serious health problems by damaging the blood-thymus barrier (BTB) and leading to immune system injuries.
  • Sulforaphane (SFN), a natural compound with antioxidant properties, was studied to see if it could counteract the harmful effects of Cd in chicks over 90 days.
  • The research found that SFN helps restore BTB function and reduce immune damage by modulating specific cellular pathways, indicating its potential for protecting against Cd-related health issues in the thymus.
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  • Methylmercury (MeHg) production in water bodies poses a significant global risk due to its harmful neurotoxic effects, and dissolved organic matter (DOM) is vital in the mercury cycling process.
  • Research found that algae-derived DOM increases MeHg levels and methylation rates significantly more than terrestrial-derived DOM, enhancing net MeHg formation in eutrophic lakes.
  • The study highlights that different DOM compositions impact mercury methylation and demethylation processes differently, suggesting that these factors need to be considered in environmental risk assessments related to mercury in aquatic systems.
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Background: The benefits of healthy lifestyles are well recognized. However, the extent to which improving unhealthy lifestyles reduces cardiovascular disease (CVD) risk needs to be discussed. We evaluated the impact of lifestyle improvement on CVD incidence using data from the China-PAR project (Prediction for Atherosclerotic Cardiovascular Disease Risk in China).

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  • Cadmium (Cd) is a toxic heavy metal known to harm the nervous system, while Selenium (Se) can counteract its toxicity and has antioxidant benefits.
  • This study investigates the brain damage caused by high levels of Cd and how Nano-selenium (Nano-Se) can help mitigate this injury.
  • Results showed that Cd exposure led to neuron loss and cellular swelling, but Nano-Se improved neuronal structure and function, reduced neuroinflammation, and influenced gene expression related to cell function, indicating its protective effects against Cd-induced brain injury.
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  • - Cadmium is toxic and can accumulate in the food chain, posing risks to both humans and animals, but its neurological effects are not fully understood.
  • - In a study, male chickens were given different concentrations of cadmium for 90 days, revealing that high doses caused damage to the brain's striatum and led to neuron degeneration and astrocyte dysfunction.
  • - The research identified that cadmium exposure transformed astrocytes into an A1 state by internalizing the gap junction protein connexin 43, suggesting a specific target for cadmium's neurotoxic effects and potential avenues for future research on treating related nervous system diseases.
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  • Wulfenioidones A - K are a group of compounds derived from the plant Orthosiphon wulfenioides, characterized by a complex tricyclic structure and defined using various analytical techniques like spectroscopy and X-ray crystallography.
  • Compounds 1-4, 6, and 8 showed significant inhibition of lactate dehydrogenase (LDH) with varying effectiveness, indicating potential for controlling macrophage cell pyroptosis triggered by specific signals.
  • Specifically, compound 1 was found to selectively inhibit the NLRP3 inflammasome, as shown through analyses of relevant proteins and cell morphology, reinforcing its potential as a therapeutic agent.
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  • Cadmium (Cd) is a significant environmental pollutant that can penetrate the blood-brain barrier and cause brain damage, but its effects on the barrier itself are not fully understood.
  • In a study with 80 newly hatched chicks, different groups were fed varying levels of Cd to observe its impact over 90 days, resulting in capillary damage and neuron loss related to dysfunction of the blood-brain barrier.
  • The research found that Cd exposure weakened the Wnt/β-catenin signaling pathway, leading to inflammation and impaired formation of crucial junctions that maintain blood-brain barrier integrity.
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  • The study investigates left atrial appendage (LAA) thrombosis as a major complication in non-valvular atrial fibrillation (NVAF) and proposes a machine learning method to predict its risk.
  • Researchers analyzed data from 713 NVAF patients, identifying key risk factors and employing advanced algorithms like Random Forest and eXtreme Gradient Boosting to create a predictive model.
  • The resulting RXTP model showed superior accuracy (0.865) compared to traditional scoring methods (CHADS2 and CHA2DS2-VASc), highlighting the importance of specific factors like B-type natriuretic peptide and left atrial appendage width in predicting LAA thrombosis risk.
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Di(2-ethylhexyl) phthalate (DEHP) is a highly harmful and persistent environmental pollutant. Due to its unique chemical composition, it frequently dissolves and enters the environment to endanger human and animal health. Lycopene is a natural bioactive component that can potentially reduce the risk of environmental factor-induced chronic diseases.

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Cadmium is a global ecological toxic pollutant; in animals, hepatotoxic fibrosis is caused by bioaccumulation of Cd through food chains. We determined the path of nano-Se antagonism in Cd-induced hepatocyte pyroptosis by targeting the APJ-AMPK-PGC1α pathway, using an in vivo model of hepatotoxicity. All 1-day-old chicks were treated with Cd (140 mg/kg BW/day) and/or nano-Se (0.

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  • * Their structures were determined using advanced spectroscopic data and methods like DP4+ analysis for relative configurations and quantum chemical calculations for absolute configurations.
  • * Certain compounds (1, 3, 5, 9, 10, 12, 15, 16, and 19) exhibited significant inhibitory effects on NLRP3 inflammasome activation, and compound 10 specifically reduced IL-1β secretion and blocked macrophage pyroptosis in lab tests.
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  • - The study investigates the relationship between red blood cell distribution width (RDW) and plaque vulnerability in cardiovascular patients, focusing on distinctions between stable angina and acute coronary syndrome patients.
  • - It involved 105 patients, revealing that plaque rupture occurs more often in acute coronary syndrome cases, and those with ACS also had higher RDW levels compared to those with stable angina.
  • - An RDW value over 13.85% is suggested as a potential predictor of ruptured plaques, achieving a sensitivity of 72.3% and specificity of 62%.
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Di-(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in plastic products, consumer products, and packaging materials. It is of great health concern in both animals and humans as it released into the environment and entered into the body from plastic products over time, thereby resulting in neurotoxicity. As a pivotal regulator of the central nervous system (CNS), astrocytes, are crucial for maintaining brain homeostasis.

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  • Anti-thymocyte globulin (ATG) is used in allogeneic hematopoietic cell transplantation to prevent graft-versus-host disease (GVHD), but it also increases the risk of virus reactivation.
  • A study with 106 patients found that an optimal total area under the concentration-time curve (AUC) for active ATG was between 100 to 148.5 UE/mL/day, effectively reducing the risk of cytomegalovirus reactivation while maintaining engraftment.
  • The optimal AUC group had significantly lower rates of cytomegalovirus and Epstein-Barr virus reactivation compared to the non-optimal group, but there was no difference in overall EBV reactivation.
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  • * These compounds showed varying inhibitory effects on SARS-CoV-2 main protease, with specific compounds demonstrating significant potency against the virus.
  • * Additionally, most compounds exhibited anti-inflammatory properties by inhibiting key inflammatory markers, suggesting their potential for COVID-19 treatment.
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  • The study aimed to assess lymphocyte subsets and myeloid-derived suppressor cells (MDSC) in patients with newly diagnosed intermediate- to high-risk acute graft-versus-host disease (aGVHD) treated with steroids and ruxolitinib.
  • Out of 23 patients treated, the complete response rate was 78.26% after 28 days, with observed changes in certain lymphocyte levels, indicating a potential treatment response.
  • The researchers found significant differences in MDSC levels between patients with and without aGVHD, suggesting the effectiveness of the steroids-ruxolitinib treatment in modifying immune cell activity in these patients.
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Background: Association between tea consumption and incident hypertension remains uncertain. This study conducted to examine the health effects of tea consumption on blood pressure progression and hypertension incidence.

Methods: A population-based cohort of 38,913 Chinese participants without hypertension at baseline were included in the current study.

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  • The review aims to connect clinical and basic research by outlining the cellular and molecular mechanisms of cardioprotection and assessing evidence about high-energy phosphates (HEPs) in ischemic heart disease (IHD).
  • Exogenous creatine phosphate (CrP) is highlighted as a potential key metabolic regulator that offers cardioprotection through various complex mechanisms, primarily by replenishing cellular energy.
  • While CrP has not been shown to enhance long-term survival rates, it has demonstrated beneficial effects on several important secondary outcomes, indicating a need for well-designed multicenter randomized controlled trials (RCTs) to further investigate its impact on long-term survival.
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Myxofibrosarcoma is a common soft-tissue sarcoma in elderly patients, characterized by an infiltrative growth pattern and a high risk for persistent local recurrence. A 35-years-old woman was diagnosed with myxofibrosarcoma on the right upper arm and the tumor is surgically resected. The tumor relapsed 7 months later.

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We investigated the association between plasma microRNA (miR)-204 and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus (T2DM). We consecutively enrolled 179 individuals with T2DM who underwent coronary computed tomography at Anzhen Hospital from January 2015 to September 2016. The CAC score (CACS) was expressed in Agatston units and >10 Hounsfield units were defined as CAC-positive status.

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Objective: To evaluate the effects and mechanisms of glucose-insulin-potassium (GIK) on post-procedural myocardial injury (PMI) after percutaneous coronary intervention (PCI).

Methods: A total of 200 non-diabetic patients with documented coronary heart disease (CHD) were divided into the Group GIK and Group G, with 100 patients in each group. Patients in Group G were given intravenous infusion of glucose solution 2 hours before PCI.

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