Molecular simulations of the effects of substitutions on the dissolution properties of amorphous cellulose acetate.

The dissolution behavior of cellulose acetate (CA) is an extremely important property in its extensive applications and preparation of derivatives. In this paper, we proposed a molecular model building strategy to construct amorphous CA with various substituent distributions (different degrees of substitution and substitution positions). A protocol combing molecular dynamics simulation and density functional theory (DFT) was applied to systematically investigate the dissolution behavior of CAs, and the structural properties of CAs.

Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats.

Hydrogen sulfide (H(2)S) is a gasotransmitter that regulates cardiovascular functions. The present study aimed to examine the hypothesis that chronic treatment with sodium hydrosulfide (NaHS, an H(2)S donor) is able to prevent left-ventricular remodeling in spontaneously hypertensive rats (SHR). Four-week-old SHR were treated with NaHS (10, 30, and 90 micromol x kg(-1) x day(-1)), a combination of NaHS (30 micromol x kg(-1) x day(-1)) and glibenclamide (5 mg x kg(-1) x day(-1)), glibenclamide alone (5 mg x kg(-1) x day(-1)), hydralazine alone (10 mg x kg(-1) x day(-1)), and placebo for 3 mo.