Publications by authors named "Ying-Qi Fang"
[In vitro transcription synthesis and effects of FLT3 targeted short hairpin RNA].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2007
Article Synopsis
- FMS-like tyrosine kinase 3 (FLT3) is commonly activated in acute myeloid leukemia and is linked to poor patient outcomes.
- Three specific short hairpin RNAs (FLT3-shRNAs) were designed to silence FLT3 in THP-1 leukemia cells, with shRNA1 showing the strongest inhibition.
- After 72 hours of treatment with shRNA1, FLT3 mRNA and protein levels were significantly reduced, indicating its potential for future research on FLT3-targeted therapies.